Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods

Hao Ding; Ming Cao; Andrew W. DuPont; Larry D. Scott; Sushovan Guha; Shashideep Singhal; Mamoun Younes; Isaac Pence; Alan Herline; David Schwartz; Hua Xu; Anita Mahadevan-Jansen; Xiaohong Bi

doi:10.1117/12.2225299

7 March 2016 Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods

Hao Ding, Ming Cao, Andrew W. DuPont, Larry D. Scott, Sushovan Guha, Shashideep Singhal, Mamoun Younes, Isaac Pence, Alan Herline, David Schwartz, Hua Xu, Anita Mahadevan-Jansen, Xiaohong Bi

Author Affiliations +

Proceedings Volume 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry; 97040W (2016) https://doi.org/10.1117/12.2225299
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Inflammatory bowel disease (IBD) is an idiopathic disease that is typically characterized by chronic inflammation of the gastrointestinal tract. Recently much effort has been devoted to the development of novel diagnostic tools that can assist physicians for fast, accurate, and automated diagnosis of the disease. Previous research based on Raman spectroscopy has shown promising results in differentiating IBD patients from normal screening cases. In the current study, we examined IBD patients in vivo through a colonoscope-coupled Raman system. Optical diagnosis for IBD discrimination was conducted based on full-range spectra using multivariate statistical methods. Further, we incorporated several feature selection methods in machine learning into the classification model. The diagnostic performance for disease differentiation was significantly improved after feature selection. Our results showed that improved IBD diagnosis can be achieved using Raman spectroscopy in combination with multivariate analysis and feature selection.

Citation Download Citation

Hao Ding, Ming Cao, Andrew W. DuPont, Larry D. Scott, Sushovan Guha, Shashideep Singhal, Mamoun Younes, Isaac Pence, Alan Herline, David Schwartz, Hua Xu, Anita Mahadevan-Jansen, and Xiaohong Bi "Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods", Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 97040W (7 March 2016); https://doi.org/10.1117/12.2225299

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available