Generation of anatomically realistic numerical phantoms for optoacoustic breast imaging

Yang Lou; Kenji Mitsuhashi; Catherine M. Appleton; Alexander Oraevsky; Mark A. Anastasio

doi:10.1117/12.2217609

15 March 2016 Generation of anatomically realistic numerical phantoms for optoacoustic breast imaging

Yang Lou, Kenji Mitsuhashi, Catherine M. Appleton, Alexander Oraevsky, Mark A. Anastasio

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97084O (2016) https://doi.org/10.1117/12.2217609
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Because optoacoustic tomography (OAT) can provide functional information based on hemoglobin contrast, it is a promising imaging modality for breast cancer diagnosis. Developing an effective OAT breast imaging system requires balancing multiple design constraints, which can be expensive and time-consuming. Therefore, computer- simulation studies are often conducted to facilitate this task. However, most existing computer-simulation studies of OAT breast imaging employ simple phantoms such as spheres or cylinders that over-simplify the complex anatomical structures in breasts, thus limiting the value of these studies in guiding real-world system design. In this work, we propose a method to generate realistic numerical breast phantoms for OAT research based on clinical magnetic resonance imaging (MRI) data. The phantoms include a skin layer that defines breast-air boundary, major vessel branches that affect light absorption in the breast, and fatty tissue and fibroglandular tissue whose acoustical heterogeneity perturbs acoustic wave propagation. By assigning realistic optical and acoustic parameters to different tissue types, we establish both optic and acoustic breast phantoms, which will be exported into standard data formats for cross-platform usage.

Citation Download Citation

Yang Lou, Kenji Mitsuhashi, Catherine M. Appleton, Alexander Oraevsky, and Mark A. Anastasio "Generation of anatomically realistic numerical phantoms for optoacoustic breast imaging", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084O (15 March 2016); https://doi.org/10.1117/12.2217609

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