3D printing of tissue-simulating phantoms as a traceable standard for biomedical optical measurement

Erbao Dong; Minjie Wang; Shuwei Shen; Yilin Han; Qiang Wu; Ronald Xu

doi:10.1117/12.2218698

26 January 2016 3D printing of tissue-simulating phantoms as a traceable standard for biomedical optical measurement

Erbao Dong, Minjie Wang, Shuwei Shen, Yilin Han, Qiang Wu, Ronald Xu

Proceedings Volume 9903, Seventh International Symposium on Precision Mechanical Measurements; 990302 (2016) https://doi.org/10.1117/12.2218698
Event: Seventh International Symposium on Precision Mechanical Measurements, 2015, Xia'men, China

Abstract

Optical phantoms are commonly used to validate and calibrate biomedical optical devices in order to ensure accurate measurement of optical properties in biological tissue. However, commonly used optical phantoms are based on homogenous materials that reflect neither optical properties nor multi-layer heterogeneities of biological tissue. Using these phantoms for optical calibration may result in significant bias in biological measurement. We propose to characterize and fabricate tissue simulating phantoms that simulate not only the multi-layer heterogeneities but also optical properties of biological tissue. The tissue characterization module detects tissue structural and functional properties in vivo. The phantom printing module generates 3D tissue structures at different scales by layer-by-layer deposition of phantom materials with different optical properties. The ultimate goal is to fabricate multi-layer tissue simulating phantoms as a traceable standard for optimal calibration of biomedical optical spectral devices.

Citation Download Citation

Erbao Dong, Minjie Wang, Shuwei Shen, Yilin Han, Qiang Wu, and Ronald Xu "3D printing of tissue-simulating phantoms as a traceable standard for biomedical optical measurement", Proc. SPIE 9903, Seventh International Symposium on Precision Mechanical Measurements, 990302 (26 January 2016); https://doi.org/10.1117/12.2218698

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