Patient-specific treatment planning improves eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective simulation study

Zihao Li; Lam Nguyen; David Bass; Timothy M. Baran

doi:10.1117/12.2608898

7 March 2022 Patient-specific treatment planning improves eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective simulation study

Zihao Li, Lam Nguyen, David Bass, Timothy M. Baran

Author Affiliations +

Proceedings Volume PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022; PC1193909 (2022) https://doi.org/10.1117/12.2608898
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

We are investigating use of methylene blue photodynamic therapy (MB-PDT) to treat deep tissue abscesses. Monte Carlo simulations incorporating patient-specific CT images (60 subjects) were utilized to examine the effect of optical properties on the generation of patient-specific treatment plans. We investigated the influence of varying abscess wall absorption and Intralipid-induced scattering within the cavity on threshold optical power and eligibility for MB-PDT. When Intralipid concentration and delivered optical power were optimized simultaneously for each patient, eligibility for MB-PDT increased greatly from 42% to 92%, though this was diminished by the presence of absorption within the cavity.

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Zihao Li, Lam Nguyen, David Bass, and Timothy M. Baran "Patient-specific treatment planning improves eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective simulation study", Proc. SPIE PC11939, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2022, PC1193909 (7 March 2022); https://doi.org/10.1117/12.2608898

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