In vivo fiberoptic Raman spectroscopy enables real-time post-treatment surveying and tumor recurrence detection for nose cancer patients

Chi Shu; Zhiwei Huang; Wei Zheng; Kan Lin; Chweeming Lim

doi:10.1117/12.2607347

7 March 2022 In vivo fiberoptic Raman spectroscopy enables real-time post-treatment surveying and tumor recurrence detection for nose cancer patients

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, Chweeming Lim

Author Affiliations +

Proceedings Volume PC11954, Optical Biopsy XX: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC1195409 (2022) https://doi.org/10.1117/12.2607347
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We report the utility of fiberoptic Raman spectroscopy for realizing post-treatment NPC patients surveying and accurate detection of tumor recurrence. Distinct Raman spectral differences are observed among the tissue Raman spectra of normal, NPC, and non-recurring post-treatment patients. The classification models using the in vivo fingerprint and high-wavenumber (FP/HW) tissue Raman spectra together with the partial-least-squares linear-discriminant-analysis (PLS-LDA) provide the high diagnostic accuracy for detecting recurrent NPC from both inflammation and long-term post-treatment fibrosis. We further quantitatively analyze the major biochemicals related to the NPC malignancy (e.g., triolein, elastin, keratin, fibrillar collagen, and type IV collagen, etc.). This study suggests that fiberoptic Raman spectroscopy can enable real-time in-vivo post-treatment patients surveying and tumor recurrence detection with high biomolecular sensitiveness.

Conference Presentation

Citation Download Citation

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, and Chweeming Lim "In vivo fiberoptic Raman spectroscopy enables real-time post-treatment surveying and tumor recurrence detection for nose cancer patients", Proc. SPIE PC11954, Optical Biopsy XX: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC1195409 (7 March 2022); https://doi.org/10.1117/12.2607347

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