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7 March 2022 Diffusing applicator-assisted photothermal therapy for enhanced treatment of tumor tissue
Van Gia Truong, Hyejin Kim, Van Nam Tran, Hyun Wook Kang
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Proceedings Volume PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; PC119580J (2022) https://doi.org/10.1117/12.2612145
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The aim of the current study was to investigate the effect of spatial light distribution from flat (FA) and diffusing applicator (DA) on photothermal therapy (PTT) of tumor treatment in in vivo models. Due to cylindrical and wide light distribution, DA yielded uniform thermal coagulation as well as covering the entire tumor region while FA partially ablated the tumor (i.e., two-fold larger). In vivo tests presented that the DA group significantly reduced the tumor volume (i.e., 0.7 cm3), whereas the FA group yielded unpredictable tumor removal and remarkably tumor growth (i.e., 1.6 cm3) after seven-days treatment (Day 7). The proposed DA-assisted PTT can be a feasible way to treat prostate tumor in an effective and safe manner.
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Van Gia Truong, Hyejin Kim, Van Nam Tran, and Hyun Wook Kang "Diffusing applicator-assisted photothermal therapy for enhanced treatment of tumor tissue", Proc. SPIE PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, PC119580J (7 March 2022); https://doi.org/10.1117/12.2612145
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KEYWORDS
Tumors
Tissue optics
Cancer
In vivo imaging
Optical components
Prostate
Safety
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