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Stiffness is a biomarker to distinguish intestinal inflammation and fibrosis in Crohn’s disease. This study investigated the performance of an endoscopic photoacoustic (PA)-ultrasound (US) catheter probe in quantifying intestinal stiffness in rabbits in vivo. The probe integrated a miniaturized US array and a side-firing fiber optic inside a medical balloon catheter. During the balloon dilation, the ratios between the intestinal wall deformation and PA signal change were quantified. The strain-PA ratios measured in vivo demonstrated a correlation of 0.8 (n=55, p=0.01) with the Young’s moduli of the assessed intestinal segments determined by microelastometry ex vivo.
Linyu Ni,Yunhao Zhu,Laura Johnson,Jonathan Rubin,Peter Higgins,Xueding Wang, andGuan Xu
"Characterizing the biomechanical marker of intestinal fibrosis using endoscopic strain-photoacoustic imaging", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602I (7 March 2022); https://doi.org/10.1117/12.2609774
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Linyu Ni, Yunhao Zhu, Laura Johnson, Jonathan Rubin, Peter Higgins, Xueding Wang, Guan Xu, "Characterizing the biomechanical marker of intestinal fibrosis using endoscopic strain-photoacoustic imaging," Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602I (7 March 2022); https://doi.org/10.1117/12.2609774