Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography

Samuel S. Streeter; Benjamin W. Maloney; Rebecca A. Zuurbier; Wendy A. Wells; Richard J. Barth Jr.; Keith D. Paulsen; Brian W. Pogue

doi:10.1117/12.2612080

3 March 2022 Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography

Samuel S. Streeter, Benjamin W. Maloney, Rebecca A. Zuurbier, Wendy A. Wells, Richard J. Barth Jr., Keith D. Paulsen, Brian W. Pogue

Author Affiliations +

Proceedings Volume PC11974, Biomedical Applications of Light Scattering XII; PC1197404 (2022) https://doi.org/10.1117/12.2612080
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Re-excision procedures are frequent in breast-conserving surgery due to residual tumor left behind after initial resection. Projection radiography and volumetric X-ray imaging are used to assess margin adequacy, but X-ray imaging lacks contrast between healthy, abnormal benign, and malignant fibrous tissues important for surgical decision making. The purpose of this study was to compare micro-CT and optical scatter imagery of surgical breast specimens and to demonstrate enhanced contrast to intra-tumoral morphologies and tumor boundary features revealed by optical scatter imaging. Results suggest that optical scatter imaging reveals additional tissue features that could improve margin assessment over X-ray imaging alone.

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Samuel S. Streeter, Benjamin W. Maloney, Rebecca A. Zuurbier, Wendy A. Wells, Richard J. Barth Jr., Keith D. Paulsen, and Brian W. Pogue "Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography", Proc. SPIE PC11974, Biomedical Applications of Light Scattering XII, PC1197404 (3 March 2022); https://doi.org/10.1117/12.2612080

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