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DNA nanotechnology is a powerful approach for design of nanostructures with applications including single molecule sensing, drug delivery, and manipulating molecular components. We recently developed an approach that merges top-down and bottom-up design to enable DNA assemblies with complex geometries with many components, programmed dynamic properties, and the ability to actuate and assemble into higher order systems. We demonstrate this approach through fabrication of complex assemblies including a nanoscale DNA airplane. These assemblies are ideally suited to manipulate other nanoscale objects or materials. We recently demonstrated the ability to template reconfigurable assemblies of nanoparticles and apply tunable forces to biomolecules.
Carlos Castro
"Design of DNA based dynamic devices, assemblies, and composites", Proc. SPIE PC12054, Novel Patterning Technologies 2022, PC120540L (13 June 2022); https://doi.org/10.1117/12.2621401
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Carlos Castro, "Design of DNA based dynamic devices, assemblies, and composites," Proc. SPIE PC12054, Novel Patterning Technologies 2022, PC120540L (13 June 2022); https://doi.org/10.1117/12.2621401