Characterizing and overcoming the confounding effects of skin pigmentation for improved quantification of tissue oxygenation and hemodynamic changes across all skin types

Robert H. Wilson; Gordon T. Kennedy; Thinh Phan; Wei Jin; Anthony J. Durkin

doi:10.1117/12.2650525

6 March 2023 Characterizing and overcoming the confounding effects of skin pigmentation for improved quantification of tissue oxygenation and hemodynamic changes across all skin types

Robert H. Wilson, Gordon T. Kennedy, Thinh Phan, Wei Jin, Anthony J. Durkin

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Proceedings Volume PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV; PC1237506 (2023) https://doi.org/10.1117/12.2650525
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Absorption of light by epidermal melanin can confound light-based measurements of tissue oxygenation, reducing the ability of these technologies to reliably identify hypoxia. Spatial frequency domain imaging (SFDI) may help address this critical concern, because the different spatial frequencies of light penetrate different depths into the tissue, facilitating separation between contributions of different tissue layers to the detected signal. Here, we rigorously investigate the relationship between the skin tone of healthy subjects and the tissue oxygen saturation (StO2) measured with multispectral SFDI. This study helps to quantify the degree to which skin tone influences SFDI measurements of tissue oxygenation.

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Robert H. Wilson, Gordon T. Kennedy, Thinh Phan, Wei Jin, and Anthony J. Durkin "Characterizing and overcoming the confounding effects of skin pigmentation for improved quantification of tissue oxygenation and hemodynamic changes across all skin types", Proc. SPIE PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV, PC1237506 (6 March 2023); https://doi.org/10.1117/12.2650525

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KEYWORDS

Skin

Hemodynamics

Tissues

Tissue optics

Oxygen

Mathematical modeling

Monte Carlo methods

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