Rapid disassembly of bacterial biofilms by a blue light-ferric modality

Yongli Li; Mei X. Wu; Zhengkun Zhang; Yan Dong

doi:10.1117/12.3004474

13 March 2024 Rapid disassembly of bacterial biofilms by a blue light-ferric modality

Yongli Li, Mei X. Wu, Zhengkun Zhang, Yan Dong

Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220L (2024) https://doi.org/10.1117/12.3004474
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Biofilms often persist in wounds because the extracellular polymeric substances (EPS) can protect embedded bacteria against host phagocytes. Treatment options for wound biofilms are limited due to antibiotic resistance and tolerance. Wound debridement remains a routine practice to disrupt the resilient biofilms by mechanical forces, but it is painful and must be done by well-trained professionals. Blue-light (BL) treatment represents a rising alternative for managing wound infections because it can directly inactivate a number of bacterial species and prevent biofilm formation. However, established biofilms remain recalcitrant to BL-mediated eradication. To enhance BL’s efficacy on mature biofilms, we investigated whether BL could directly and sufficiently disassemble the extracellular matrix when combined with other elements.

Conference Presentation

Citation Download Citation

Yongli Li, Mei X. Wu, Zhengkun Zhang, and Yan Dong "Rapid disassembly of bacterial biofilms by a blue light-ferric modality", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220L (13 March 2024); https://doi.org/10.1117/12.3004474

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