Pancreatic cancer is the fourth leading cause of cancer deaths. The poor diagnosis, early metastasis, limited drug accumulation in the tumor microenvironment, and acquired resistance to salvage chemotherapeutic cocktails lead to poor clinical outcomes. To overcome this complex problem, personalized combination treatments have been proposed to guide the clinical management of PDAC patients. In this context, we propose the use of novel delivery systems where light is not a mere spectator, but the main character that apart from inducing cytotoxicity also promotes the release of the cargo at the right time in the right place.
|