Widefield mapping of tissue oxygen saturation through a flexible colonoscope

Taylor L. Bobrow; Nicholas J. Durr

doi:10.1117/12.3003557

13 March 2024 Widefield mapping of tissue oxygen saturation through a flexible colonoscope

Taylor L. Bobrow, Nicholas J. Durr

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC1282504 (2024) https://doi.org/10.1117/12.3003557
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Endogenous chromophore mapping has been applied for distinguishing healthy and malignant tissue, but challenges with adapting these techniques for use with flexible endoscopes have limited exploration in gastrointestinal imaging. To enable investigative imaging in-vivo, a clinical colonoscope was retrofitted with custom fiber optics for coupling with both standard-of-care and external light sources. A multispectral illumination source with eight narrowband channels was constructed from multimode laser diodes for measuring tissue reflectance. Following benchtop validation with calibration targets, the system and correction methods were applied to human screening colonoscopies to estimate oxygen saturation of lesions and surrounding healthy tissue.

Conference Presentation

Citation Download Citation

Taylor L. Bobrow and Nicholas J. Durr "Widefield mapping of tissue oxygen saturation through a flexible colonoscope", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC1282504 (13 March 2024); https://doi.org/10.1117/12.3003557

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