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Diffuse in-vivo Flow Cytometry (DiFC) is a fluorescence sensing method to detect labeled circulating cells
in-vivo non-invasively. The Dual-Ratio (DR) is an optical measurement method that aims to suppress most noise
and enhance SNR in deep tissue regions. We investigate DR applied to Near-InfraRed (NIR) DiFC to improve
circulating cells’ maximum detectable depth and SNR. Results indicate that two critical conditions control
the success of DR DiFC. First, the fraction of noise that DR methods cannot cancel (i.e., non-multiplicative
factors) cannot dominate. Second, DR DiFC has an advantage regarding SNR if the spatial distribution of tissue
autofluorescence contributors is surface-weighted.
Conference Presentation
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Giles Blaney, Fernando Ivich, Angelo Sassaroli, Mark Niedre, Sergio Fantini, "Dual-ratio technique to improve detection depth in diffuse in-vivo fluorescence flow cytometry," Proc. SPIE PC12827, Multiscale Imaging and Spectroscopy V, PC1282705 (13 March 2024); https://doi.org/10.1117/12.3001842