Inter-plexus connection visualization and graph representation of retinal vasculature using optimally oriented flux OCTA

Yunchan Hwang; Jungeun Won; Hiroyuki Takahashi; Antonio Yaghy; Nadia K. Waheed; James G. Fujimoto

doi:10.1117/12.3005580

13 March 2024 Inter-plexus connection visualization and graph representation of retinal vasculature using optimally oriented flux OCTA

Yunchan Hwang, Jungeun Won, Hiroyuki Takahashi, Antonio Yaghy, Nadia K. Waheed, James G. Fujimoto

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Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC1283004 (2024) https://doi.org/10.1117/12.3005580
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The retinal vasculature has plexuses at multiple depths, interconnected in a complex pattern. While optical coherence tomography angiography (OCTA) visualizes the vasculature at the capillary level, creating a 3D representation of the vasculature, including the connections between plexuses, remains a challenge. Here, we employ Optimally Oriented Flux (OOF) on retinal OCTA to simultaneously preserve the inter-plexus connections and suppress projection artifacts, facilitating high-contrast 3D visualization of the vasculature. Furthermore, a novel framework is developed to transform the vasculature into a graph, which enables quantification of ‘importance’ of each capillary using betweenness centrality and simulation of capillary non-perfusion.

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Citation Download Citation

Yunchan Hwang, Jungeun Won, Hiroyuki Takahashi, Antonio Yaghy, Nadia K. Waheed, and James G. Fujimoto "Inter-plexus connection visualization and graph representation of retinal vasculature using optimally oriented flux OCTA", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC1283004 (13 March 2024); https://doi.org/10.1117/12.3005580

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KEYWORDS

Capillaries

Visualization

3D projection

Optical spheres

Target detection

Brain

In vivo imaging

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