Flexible endomicroscopy with quantitative phase imaging

Jingyi Wang; Chenfei Hu; Yuheng Jiao; Wu You; Yu Ke; Wenlong Lu

doi:10.1117/12.2688032

13 March 2024 Flexible endomicroscopy with quantitative phase imaging

Jingyi Wang, Chenfei Hu, Yuheng Jiao, Wu You, Yu Ke, Wenlong Lu

Proceedings Volume PC12852, Quantitative Phase Imaging X; PC1285210 (2024) https://doi.org/10.1117/12.2688032
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

We developed a flexible endomicroscopy (FEM) in reflection geometry for quantitative phase imaging of unlabeled thick samples. FEM provides the phase information by wavefront modulation using chessboard grating and phase-shifting. FEM system features high lateral and axial resolutions of 1.2 and 8.3 μm, respectively, with a probe diameter of 2.5 mm. By testing pathologic slices and thick opaque mammalian tissue, FEM identifies normal and tumor glandular structures, secreta, and tomographic skin layers. With the potential for direct morphological and phase measurement, high resolution, and thin fiber tip, the label-free FEM could be an attractive tool for various clinical applications.

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Jingyi Wang, Chenfei Hu, Yuheng Jiao, Wu You, Yu Ke, and Wenlong Lu "Flexible endomicroscopy with quantitative phase imaging", Proc. SPIE PC12852, Quantitative Phase Imaging X, PC1285210 (13 March 2024); https://doi.org/10.1117/12.2688032

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