An image navigation (NAV) and registration (INR) performance assessment tool set (IPATS) was developed to assess the US Geostationary Operational Environmental Satellite R-series (GOES-R) Advanced Baseline Imager (ABI) and Geostationary Lightning Mapper (GLM) INR performance. IPATS produces five INR metrics for level 1B ABI images: navigation, channel-to-channel registration, frame-to-frame registration, swath-to-swath registration, and within-frame registration. IPATS also produces one INR metric for GLM: navigation of background images. The high-precision INR metrics produced by IPATS are critical to INR performance evaluation and long-term monitoring. IPATS INR metrics also provide feedback to INR engineers for tuning the navigation algorithms and parameters to further refine INR performance. IPATS utilizes a modular algorithm design to allow the user-selectable data processing sequence and configuration parameters. We first describe the algorithmic design and the implementation of IPATS. Next, it describes the investigation of the optimization of the configuration parameters to reduce measurement errors. Finally, sample INR performance is presented, including GOES-16 and GOES-17 ABI NAV performance from postlaunch test to November 2019 and the comparison of example 24-h INR performance against the mission performance requirements. The INR assessment results show that both GOES-R ABIs are in compliance with the mission INR requirements.