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21 May 2012 Determination of optical absorption coefficient with focusing photoacoustic imaging
Zhifang Li, Hui Li, Zhiping Zeng, Wenming Xie, Wei R. Chen
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Journal of Biomedical Optics, Vol. 17, Issue 6, 061216 (May 2012). https://doi.org/10.1117/1.JBO.17.6.061216
Abstract
Absorption coefficient of biological tissue is an important factor for photothermal therapy and photoacoustic imaging. However, its determination remains a challenge. In this paper, we propose a method using focusing photoacoustic imaging technique to quantify the target optical absorption coefficient. It utilizes the ratio of the amplitude of the peak signal from the top boundary of the target to that from the bottom boundary based on wavelet transform. This method is self-calibrating. Factors, such as absolute optical fluence, ultrasound parameters, and Grüneisen parameter, can be canceled by dividing the amplitudes of the two peaks. To demonstrate this method, we quantified the optical absorption coefficient of a target with various concentrations of an absorbing dye. This method is particularly useful to provide accurate absorption coefficient for predicting the outcomes of photothermal interaction for cancer treatment with absorption enhancement.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Zhifang Li, Hui Li, Zhiping Zeng, Wenming Xie, and Wei R. Chen "Determination of optical absorption coefficient with focusing photoacoustic imaging," Journal of Biomedical Optics 17(6), 061216 (21 May 2012). https://doi.org/10.1117/1.JBO.17.6.061216
Published: 21 May 2012
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Cited by 12 scholarly publications.
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KEYWORDS
Absorption
Photoacoustic spectroscopy
Photoacoustic imaging
Signal attenuation
Signal detection
Tissue optics
Acoustics
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