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9 April 2015 Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra
Lianpeng Zhou, Guoyong Wu, Huajiang Wei, Zhouyi Guo, Hongqin Yang, Yonghong He, Shusen Xie, Ying Liu, Qingan Meng
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Journal of Biomedical Optics, Vol. 20, Issue 4, 046003 (April 2015). https://doi.org/10.1117/1.JBO.20.4.046003
Abstract
The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment increased the amounts of TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue optical properties were significantly influenced by accumulation of TiO2 NPs.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Lianpeng Zhou, Guoyong Wu, Huajiang Wei, Zhouyi Guo, Hongqin Yang, Yonghong He, Shusen Xie, Ying Liu, and Qingan Meng "Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra," Journal of Biomedical Optics 20(4), 046003 (9 April 2015). https://doi.org/10.1117/1.JBO.20.4.046003
Published: 9 April 2015
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Cited by 6 scholarly publications.
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KEYWORDS
Tissues
Nanoparticles
Signal attenuation
Lung
Optical coherence tomography
Semiconductor lasers
Optical properties
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