Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

Zhongdi Chu; Chieh-Li Chen; Qinqin Zhang; Kathryn Pepple M.D.; Mary Durbin; Giovanni Gregori; Ruikang K. Wang

doi:10.1117/1.JBO.22.12.121705

24 November 2017 Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

Zhongdi Chu, Chieh-Li Chen, Qinqin Zhang, Kathryn Pepple M.D., Mary Durbin, Giovanni Gregori, Ruikang K. Wang

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Journal of Biomedical Optics, Vol. 22, Issue 12, 121705 (November 2017). https://doi.org/10.1117/1.JBO.22.12.121705

Abstract

The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT). We show that the complex signal-based OMAG was superior to both the phase and amplitude signal-based approaches in detailing the vascular lobules previously seen with histological analysis. With this improved ability to visualize the lobular vascular networks, it is possible to identify the feeding arterioles and draining venules around the lobules, which is important in understanding the role of the CC in the pathogenesis of ocular diseases. With built-in FastTrac^™ and montage scanning capabilities, we also demonstrate wide-field SD-OCT angiograms of the CC with a field of view at 9×11 mm2.

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Zhongdi Chu, Chieh-Li Chen, Qinqin Zhang, Kathryn Pepple M.D., Mary Durbin, Giovanni Gregori, and Ruikang K. Wang "Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid," Journal of Biomedical Optics 22(12), 121705 (24 November 2017). https://doi.org/10.1117/1.JBO.22.12.121705

Received: 4 August 2017; Accepted: 8 November 2017; Published: 24 November 2017

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