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25 May 2017 Morphology alterations of skin and subcutaneous fat at NIR laser irradiation combined with delivery of encapsulated indocyanine green
Irina Yu. Yanina, Nikita A. Navolokin, Yulia I. Svenskaya, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Gleb B. Sukhorukov, Valery V. Tuchin
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Journal of Biomedical Optics, Vol. 22, Issue 5, 055008 (May 2017). https://doi.org/10.1117/1.JBO.22.5.055008
Abstract
The goal of this study is to quantify the impact of the in vivo photochemical treatment of rats with obesity using indocyanine green (ICG) dissolved in saline or dispersed in an encapsulated form at NIR laser irradiation, which was monitored by tissue sampling and histochemistry. The subcutaneous injection of the ICG solution or ICG encapsulated into polyelectrolyte microcapsules, followed by diode laser irradiation (808 nm, 8  W/cm2, 1 min), resulted in substantial differences in lipolysis of subcutaneous fat. Most of the morphology alterations occurred in response to the laser irradiation if a free-ICG solution had been injected. In such conditions, membrane disruption, stretching, and even delamination in some cases were observed for a number of cells. The encapsulated ICG aroused similar morphology changes but with weakly expressed adipocyte destruction under the laser irradiation. The Cochran Q test rendered the difference between the treatment alternatives statistically significant. By this means, laser treatment using the encapsulated form of ICG seems more promising and could be used for safe layerwise laser treatment of obesity and cellulite.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Irina Yu. Yanina, Nikita A. Navolokin, Yulia I. Svenskaya, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Gleb B. Sukhorukov, and Valery V. Tuchin "Morphology alterations of skin and subcutaneous fat at NIR laser irradiation combined with delivery of encapsulated indocyanine green," Journal of Biomedical Optics 22(5), 055008 (25 May 2017). https://doi.org/10.1117/1.JBO.22.5.055008
Received: 27 January 2017; Accepted: 2 May 2017; Published: 25 May 2017
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KEYWORDS
Laser irradiation
Indocyanine green
Near infrared
Skin
Laser therapeutics
In vivo imaging
Laser tissue interaction
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