Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study

Nico Bodenschatz; Catherine F. Poh D.D.S.; Sylvia Lam; Pierre M. Lane; Martial Guillaud; Calum E. MacAulay

doi:10.1117/1.JBO.22.8.086005

19 August 2017 Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study

Nico Bodenschatz, Catherine F. Poh D.D.S., Sylvia Lam, Pierre M. Lane, Martial Guillaud, Calum E. MacAulay

Author Affiliations +

Funded by: National Institutes of Health (NIH), Canadian Institutes of Health Research

Journal of Biomedical Optics, Vol. 22, Issue 8, 086005 (August 2017). https://doi.org/10.1117/1.JBO.22.8.086005

Abstract

Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo.

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Nico Bodenschatz, Catherine F. Poh D.D.S., Sylvia Lam, Pierre M. Lane, Martial Guillaud, and Calum E. MacAulay "Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study," Journal of Biomedical Optics 22(8), 086005 (19 August 2017). https://doi.org/10.1117/1.JBO.22.8.086005

Received: 17 April 2017; Accepted: 25 July 2017; Published: 19 August 2017

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KEYWORDS

Backscatter

Reflectivity

Spatial frequencies

Tissues

Luminescence

Endomicroscopy

Mouth

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