Purpose: In sequential imaging studies, there exists rich information from past studies that can be used in prior-image-based reconstruction (PIBR) as a form of improved regularization to yield higher-quality images in subsequent studies. PIBR methods, such as reconstruction of difference (RoD), have demonstrated great improvements in the image quality of subsequent anatomy reconstruction even when CT data are acquired at very low-exposure settings.

Approach: However, to effectively use information from past studies, two major elements are required: (1) registration, usually deformable, must be applied between the current and prior scans. Such registration is greatly complicated by potential ambiguity between patient motion and anatomical change—which is often the target of the followup study. (2) One must select regularization parameters for reliable and robust reconstruction of features.

Results: We address these two major issues and apply a modified RoD framework to the clinical problem of lung nodule surveillance. Specifically, we develop a modified deformable registration approach that enforces a locally smooth/rigid registration around the change region and extend previous analytic expressions relating reconstructed contrast to the regularization parameter and other system dependencies for reliable representation of image features. We demonstrate the efficacy of this approach using a combination of realistic digital phantoms and clinical projection data. Performance is characterized as a function of the size of the locally smooth registration region of interest as well as x-ray exposure.

Conclusions: This modified framework is effectively able to separate patient motion and anatomical change to directly highlight anatomical change in lung nodule surveillance.