Optical tomograph optimized for tumor detection inside highly absorbent organs

Jerome Boutet; Anne Koenig; Lionel Hervé; Michel Berger; Jean-Marc Dinten; Véronique Josserand; Jean-Luc Coll

doi:10.1117/1.3574768

1 May 2011 Optical tomograph optimized for tumor detection inside highly absorbent organs

Jerome Boutet, Anne Koenig, Lionel Hervé, Michel Berger, Jean-Marc Dinten, Véronique Josserand, Jean-Luc Coll

Author Affiliations +

Optical Engineering, Vol. 50, Issue 5, 053203 (May 2011). https://doi.org/10.1117/1.3574768

Abstract

This paper presents a tomograph for small animal fluorescence imaging. The compact and cost-effective system described in this article was designed to address the problem of tumor detection inside highly absorbent heterogeneous organs, such as lungs. To validate the tomograph's ability to detect cancerous nodules inside lungs, in vivo tumor growth was studied on seven cancerous mice bearing murine mammary tumors marked with Alexa Fluor 700. They were successively imaged 10, 12, and 14 days after the primary tumor implantation. The fluorescence maps were compared over this time period. As expected, the reconstructed fluorescence increases with the tumor growth stage.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jerome Boutet, Anne Koenig, Lionel Hervé, Michel Berger, Jean-Marc Dinten, Véronique Josserand, and Jean-Luc Coll "Optical tomograph optimized for tumor detection inside highly absorbent organs," Optical Engineering 50(5), 053203 (1 May 2011). https://doi.org/10.1117/1.3574768

Published: 1 May 2011

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