Prof. Alexander Khmaladze Profile

Prof. Alexander Khmaladze

Assistant Professor at Univ at Albany

SPIE Involvement:

Conference Program Committee | Author

Publications (31)

Proceedings Article | 12 March 2024 Presentation + Paper

An investigation into the depletion of iron transport-related proteins using Raman spectroscopy

Alireza Sheikhsofla, Pampa Mandal DeNivo, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 12854, 128540L (2024) https://doi.org/10.1117/12.3003873

KEYWORDS: Raman spectroscopy, Singular value decomposition, Proteins, Iron, Breast cancer, Mode conditioning cables, Matrices, Vibration, Biological samples, Cancer

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Proceedings Article | 12 March 2024 Presentation + Paper

Label-free detection and characterization of cytochrome-c in human microglial cells (HTHμ) during apoptosis via Raman spectroscopy

Alireza Sheikhsofla, Monireh Pourrahimi, Samaneh Ghazanfarpour, Shane Carney, Pampa Mandal DeNivo, Anna Sharikova, Supriya Mahajan, Jonathan Petruccelli, Alexander Khmaladze

Proceedings Volume 12854, 128540M (2024) https://doi.org/10.1117/12.3003771

KEYWORDS: Cell death, Raman spectroscopy, Singular value decomposition, Mitochondria, Proteins, Matrices, Control systems, Biological samples, Imaging systems, Signal detection

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Proceedings Article | 12 March 2024 Presentation + Paper

Detection and identification of alginate in tissue-freezing media samples using Raman spectroscopy

Monireh Pourrahimi, Samaneh Ghazanfarpour, Alireza Sheikhsofla, Rafael Pena, Jennifer Morrissey, Sujith Chander Reddy Kollampally, Anna Sharikova, Yubing Xie, Melinda Larsen, Alexander Khmaladze

Proceedings Volume 12854, 128540N (2024) https://doi.org/10.1117/12.3003876

KEYWORDS: Raman spectroscopy, Tissues, Biological samples, Hydrogels, Vibration, Wound healing, Chemical analysis, Tissue engineering, Spectroscopy, Resection

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Proceedings Article | 12 March 2024 Presentation + Paper

Measuring methamphetamine induced morphology changes in apoptotic glial cells using the transport of intensity equation, digital holographic microscopy, and diffraction tomography

Shane Carney, Alireza Sheikhsofla, Ting Chean Khoo, Samaneh Ghazanfarpour, Monireh Pourrahimi, Arthur Redgate, Stephen Rose, Madison Torres, Anna Sharikova, Supriya Mahajan, Jonathan Petruccelli, Alexander Khmaladze

Proceedings Volume 12854, 128540I (2024) https://doi.org/10.1117/12.3003357

KEYWORDS: Cell death, Digital holography, Optical path differences, Holography, Phase imaging, Microscopy, Diffraction

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Proceedings Article | 16 March 2023 Presentation + Paper

Assessment of Raman hyperspectral spectra upon depletion of proteins involved in iron transport

Pampa Mandal, Alireza Sheikhsofla, Samaneh Ghazanfarpour, Ting Chean Khoo, Jonathan Barra, Isaiah Crousborne, Anna Sharikova, Alexander Khmaladze, Margarida Barroso

Proceedings Volume 12391, 123910L (2023) https://doi.org/10.1117/12.2650402

KEYWORDS: Raman spectroscopy, Iron, Singular value decomposition, Proteins, Breast cancer, Chemical analysis, Ablation, Visualization

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Proceedings Article | 27 May 2022 Paper

The study of cell death mechanisms via simultaneous Raman and transport of intensity phase-imaging techniques

Shane Carney, Ting Chean Khoo, Jonathan Barra-Carrasco, Samaneh Ghazanfarpour, Shahab Bahreini, Anna Sharikova, Margarida Barroso, Supriya Mahajan, Jonathan Petruccelli, Alexander Khmaladze

Proceedings Volume 12144, 121440A (2022) https://doi.org/10.1117/12.2622411

KEYWORDS: Raman spectroscopy, Cell death, Breast cancer, Microscopes, Integrated optics, Digital holography, Tissues, Temporal coherence, Spectroscopy, Phase measurement

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Proceedings Article | 2 March 2022 Presentation + Paper

Quantitative volume comparisons of methamphetamine-induced apoptosis by simultaneous digital holographic microscopy and transport of intensity phase-imaging techniques

Shane Carney, Ting Chean Khoo, Kate Tubbesing, Anna Sharikova, Supriya Mahajan, Jonathan Petruccelli, Alexander Khmaladze

Proceedings Volume 11972, 119720B (2022) https://doi.org/10.1117/12.2610394

KEYWORDS: Cell death, Digital holography, Microscopy, Microscopes, Holography, Beam splitters, Cameras, Objectives, Mirrors

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Proceedings Article | 5 March 2021 Presentation + Paper

Raman mapping of transferrin and ferritin distributions in breast cancer cells

Kate Tubbesing, Ting Chean Khoo, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 11655, 1165518 (2021) https://doi.org/10.1117/12.2579413

KEYWORDS: Breast cancer, Iron, Raman spectroscopy, Fourier transforms, Proteins, Statistical analysis, Receptors, Hyperspectral imaging, Cancer

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Proceedings Article | 2 April 2020 Presentation + Paper

Measurements of iron-bound transferrin in breast cancer tumor xenografts using Raman spectral imaging

Kate Tubbesing, Ting Chean Khoo, Alena Rudkouskaya, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 11363, 113630Y (2020) https://doi.org/10.1117/12.2555211

KEYWORDS: Tumors, Raman spectroscopy, Iron, Breast cancer, Tissues, Imaging spectroscopy, Cancer, Confocal microscopy, Veins, Receptors

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Proceedings Article | 20 February 2020 Presentation + Paper

Raman hyperspectral imaging of transferrin-bound iron in T47D and MDA-MB-231 breast cancer cells

Ting Chean Khoo, Kate Tubbesing, Alena Rudkouskaya, Georgios Athanassiadis, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 11251, 112511E (2020) https://doi.org/10.1117/12.2547638

KEYWORDS: Iron, Raman spectroscopy, Breast cancer, Hyperspectral imaging, Cancer, Imaging spectroscopy, Receptors, Proteins, Tissues, Microscopy

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Proceedings Article | 20 February 2020 Presentation + Paper

Detection of the differentiation state of salivary gland organoids for tissue engineering by Raman spectroscopy

Ting Chean Khoo, Nicholas Moskwa, Georgios Athanassiadis, Anna Sharikova, Melinda Larsen, Alexander Khmaladze

Proceedings Volume 11251, 1125103 (2020) https://doi.org/10.1117/12.2547636

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Tissue engineering, Regenerative medicine, Proteins, Spectroscopy, Imaging spectroscopy, Systems modeling, Microscopes

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Proceedings Article | 20 February 2020 Presentation + Paper

Digital holographic microscopy (DHM) and transport of intensity (TIE) phase imaging of live cells

Shane Carney, Ting Chean Khoo, Jeremy Wittkopp, Kai Pisila, Georgios Athanassiadis, Anna Sharikova, Alexander Khmaladze, Jonathan Petruccelli

Proceedings Volume 11251, 1125122 (2020) https://doi.org/10.1117/12.2547934

KEYWORDS: Digital holography, Phase imaging, Holography, Microscopy, Diffraction, Microscopes

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SPIE Journal Paper | 25 April 2019 Open Access

Methamphetamine-induced apoptosis in glial cells examined under marker-free imaging modalities

Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

JBO, Vol. 24, Issue 04, 046503, (April 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.4.046503

KEYWORDS: Cell death, Raman spectroscopy, Glia, 3D image processing, Digital holography, Proteins, Control systems, Microscopes, Microscopy, Tomography

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Proceedings Article | 4 March 2019 Paper

Raman hyperspectral imaging of transferrin-bound iron in cancer cells

Ting Chean Khoo, Kate Tubbesing, Cat Pham, Habben Desta, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Proceedings Volume 10890, 108901R (2019) https://doi.org/10.1117/12.2511397

KEYWORDS: Iron, Raman spectroscopy, Breast cancer, Cancer, Hyperspectral imaging, Proteins, Imaging spectroscopy, Tissues, Spectroscopy

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Proceedings Article | 4 March 2019 Paper

Raman hyperspectral imaging of different salivary gland cell types for tissue engineering

Ting Chean Khoo, Nicholas Moskwa, Anna Sharikova, Melinda Larsen, Alexander Khmaladze

Proceedings Volume 10890, 108901S (2019) https://doi.org/10.1117/12.2511396

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Tissue engineering, Proteins, Regenerative medicine, Hyperspectral imaging, Stem cells, Microscopes, In vitro testing

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Proceedings Article | 5 June 2018 Paper

Design of a dual wavelength digital holographic imaging system for the examination of layered structures

John McFarland, Ting Chean Khoo, Anna Sharikova, Alexander Khmaladze

Proceedings Volume 10690, 1069013 (2018) https://doi.org/10.1117/12.2312274

KEYWORDS: Holography, Digital holography, Reflectivity, Reconstruction algorithms, 3D image reconstruction, Imaging systems, Optical design, Phase imaging, Electrodes, Microscopy

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Proceedings Article | 20 February 2018 Presentation + Paper

Assessing the age of animal bones and ivories by Raman spectroscopy

Anna Sharikova, Lubna Peerzada, Alexander Khmaladze

Proceedings Volume 10497, 104971B (2018) https://doi.org/10.1117/12.2291315

KEYWORDS: Raman spectroscopy, Collagen, Bone, Proteins, Statistical analysis, Molecular spectroscopy, Chemical analysis, Carbon, Organic materials, Minerals

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Proceedings Article | 29 August 2017 Paper

Double emulsion electrospun nanofibers as a growth factor delivery vehicle for salivary gland regeneration

Zahraa Foraida, Anna Sharikova, Lubna Peerzada, Alexander Khmaladze, Melinda Larsen, James Castracane

Proceedings Volume 10352, 103520E (2017) https://doi.org/10.1117/12.2275489

KEYWORDS: Nanofibers, Tissue engineering, Proteins, Tissues, Biomimetics, Polymers

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Proceedings Article | 21 February 2017 Presentation + Paper

Monitoring of live cell cultures during apoptosis by phase imaging and Raman spectroscopy

Anna Sharikova, George Saide, Lauren Sfakis, Jun Yong Park, Habben Desta, Maxwell Maloney, James Castracane, Supriya Mahajan, Alexander Khmaladze

Proceedings Volume 10074, 100740V (2017) https://doi.org/10.1117/12.2256134

KEYWORDS: Digital holography, Raman spectroscopy, Holography, Cell death, Microscopy, 3D image reconstruction, Molecular spectroscopy, Phase imaging, Live cell imaging, Medical research, Microscopes, Proteins

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Proceedings Article | 19 September 2016 Presentation + Paper

Raman hyperspectral imaging of iron transport across membranes in cells

Anupam Das, Xavier Felipe Costa, Alexander Khmaladze, Margarida Barroso, Anna Sharikova

Proceedings Volume 9976, 99760C (2016) https://doi.org/10.1117/12.2238329

KEYWORDS: Iron, Raman spectroscopy, Hyperspectral imaging, Proteins, Mode conditioning cables, Kidney, Quartz, Liver, Pathogens, Cancer

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Proceedings Article | 20 May 2016 Paper

Digital holographic phase imaging of particles embedded in microscopic structures in three dimensions

Jun Yong Park, Habben Desta, Maxwell Maloney, Anna Sharikova, Alexander Khmaladze

Proceedings Volume 9870, 98700B (2016) https://doi.org/10.1117/12.2224316

KEYWORDS: Digital holography, 3D image processing, Holography, Phase imaging, Microscopy, Reflection, Thin films, Reflectivity, Wavefronts, Refraction

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Proceedings Article | 9 March 2016 Presentation + Paper

Dual wavelength digital holographic imaging of embedded layered structures

Jun Yong Park, Xinzhong Chen, Anna Sharikova, Alexander Khmaladze

Proceedings Volume 9718, 97182J (2016) https://doi.org/10.1117/12.2212764

KEYWORDS: Digital holography, Holography, Microscopy, Electrodes, Multilayers, Phase imaging, Digital recording, Cameras, 3D image reconstruction, Holograms, Fringe analysis, Reflectivity, Imaging systems, Detection and tracking algorithms, Sensors

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Proceedings Article | 9 March 2016 Presentation + Paper

3D measurements of live cells via digital holographic microscopy and terahertz spectroscopy

Jun Yong Park, Dorian Oser, Peter Iapozzuto, Sean Norbury, Supriya Mahajan, Alexander Khmaladze, Anna Sharikova

Proceedings Volume 9718, 97182D (2016) https://doi.org/10.1117/12.2213765

KEYWORDS: Digital holography, Holography, Microscopy, Terahertz spectroscopy, Terahertz radiation, 3D metrology, Spectroscopy, 3D image reconstruction, Cell death, Microscopes, Mirrors

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Proceedings Article | 15 February 2013 Paper

Raman fiberoptic probe for monitoring human tissue engineered oral mucosa constructs

Alexander Khmaladze, Shiuhyang Kuo, Paul Okagbare, Cynthia Marcelo, Stephen Feinberg, Michael Morris

Proceedings Volume 8579, 85790L (2013) https://doi.org/10.1117/12.2005546

KEYWORDS: Raman spectroscopy, Tissues, Spectroscopy, Fiber optics, In vivo imaging, Surgery, Fiber lasers, Tissue engineering, In vitro testing, Skin

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SPIE Journal Paper | 18 May 2012

Dual-wavelength digital holographic imaging with phase background subtraction

Alexander Khmaladze, Rebecca Matz, Joshua Jasensky, Emily Seeley, Mark Banaszak Holl, Zhan Chen

OE, Vol. 51, Issue 5, 055801, (May 2012) https://doi.org/10.1117/12.10.1117/1.OE.51.5.055801

KEYWORDS: Digital holography, Holography, Phase measurement, Digital imaging, Phase imaging, Beam splitters, Microscopy, Optical engineering, 3D image processing, Phase shift keying

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Proceedings Article | 1 February 2012 Paper

Raman spectroscopic analysis of human tissue engineered oral mucosa constructs (EVPOME) perturbed by physical and biochemical methods

Alexander Khmaladze, Arindam Ganguly, Mekhala Raghavan, Shiuhyang Kuo, Jacqueline Cole, Cynthia Marcelo, Stephen Feinberg, Kenji Izumi, Michael Morris

Proceedings Volume 8219, 82190J (2012) https://doi.org/10.1117/12.908281

KEYWORDS: Raman spectroscopy, Spectroscopy, Tissue optics, Tissues, Calcium, Biological research, Surgery, In vitro testing, Skin, Spectrographs

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Proceedings Article | 7 September 2011 Paper

Hyperspectral microscopic imaging by multiplex coherent anti-Stokes Raman scattering (CARS)

Alexander Khmaladze, Joshua Jasensky, Chi Zhang, Xiaofeng Han, Jun Ding, Emily Seeley, Xinran Liu, Gary Smith, Zhan Chen

Proceedings Volume 8158, 815805 (2011) https://doi.org/10.1117/12.894258

KEYWORDS: Hyperspectral imaging, CARS tomography, Raman spectroscopy, Microscopes, Spectroscopy, CCD cameras, Microscopy, Coherence imaging, Spectral resolution, Laser scanners

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Proceedings Article | 20 May 2011 Paper

Dual wavelength digital holography phase unwrapping by linear regression

Alexander Khmaladze, Rebecca Matz, Chi Zhang, Joshua Jasensky, Mark Banaszak Holl, Zhan Chen

Proceedings Volume 8043, 80430X (2011) https://doi.org/10.1117/12.887602

KEYWORDS: Digital holography, Holography, 3D metrology, 3D image processing, Holograms, Phase imaging, Microscopy, Phase shift keying, Diffraction, 3D image reconstruction

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Proceedings Article | 23 February 2006 Paper

Use of Bessel beams and position-sensitive detectors in scanning photon microscope for improved field depth and contrast

Alexander Khmaladze, Myung Kim

Proceedings Volume 6090, 60900V (2006) https://doi.org/10.1117/12.645406

KEYWORDS: Sensors, Microscopes, Imaging systems, Scanning probe microscopy, Axicons, Photonic microstructures, Image resolution, Bessel beams, Signal detection, Photodiodes

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Proceedings Article | 1 August 2005 Paper

Scanning photon microscopy

Alexander Khmaladze, Myung Kim

Proceedings Volume 5873, (2005) https://doi.org/10.1117/12.614262

KEYWORDS: Microscopy, Image resolution, Photonic microstructures, Scanning electron microscopy, Sensors, Imaging systems, Signal detection, Image quality, Bessel beams, Near field optics

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Proceedings Article | 13 October 1995 Open Access

Windows software for enhanced studying and testing knowledge in optics

Sergey Stafeev, Vladimir Michnovetz, Alexander Khmaladze, Alexander Zinchik

Proceedings Volume 2525, (1995) https://doi.org/10.1117/12.224052

KEYWORDS: Physics, Integrated optics, Visualization, Optical testing, Optical circuits, Digital imaging, Diffraction, Software development, Optical simulations, CCD cameras

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