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A total of 196 adult persons were enrolled in the study including the group of compensated T2DM (n = 52), decompensated diabetics (n = 68), and healthy volunteers (n = 76) with normal blood glucose and without signs of cardiovascular pathology.
All participants of the study were examined with the digital optical capillaroscope (“AET”, Russia). This instrument is equipped with an image-processing program allowing for quantifying the diameters of the arterial and venous segments of the capillaries and their ratio (coefficient of remodeling), perivascular zone size, capillary blood velocity, and the degree of arterial loops narrowing and the density of the capillary network. Also we estimated the relative amount of coil-shaped capillaries.
The study revealed significant difference in the capillary density and the remodeling coefficient in comparison of T2DM patients with non-diabetic individuals. Significant changes are found in the decompensated T2DM group compared to the compensated group of diabetic patients. Furthermore, the number of coil-shaped capillaries differed greatly in T2DM patients as compared to the healthy subjects. The study did not reveal any statistically significant differences in the capillary density between the patients with compensated and decompensated T2DM.
The digital optical capillaroscope equipped with the advanced image-processing algorithm opens up new possibilities for obtaining clinically important information on microvascular abnormalities in patients suffering from diabetes mellitus.
RBC aggregation dynamics in autologous plasma and serum studied with double-channel optical tweezers
Laser diffraction analysis of shear deformability of human and rat erythrocytes in norm and ischemia
Kinetics of laser-induced phosphorescence of singlet molecular oxygen in aqueous porphyrin solutions
Optical diagnostics and mathematical models of intracellular protoplasmic mobility in amoeboid cells
Study of artificial and natural turbulence in atmospheric boundary layer with a cw Doppler CO2 lidar
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You will have access to both the presentation and article (if available).
This course will provide a description of various phenomena associated with laser interaction with whole blood and blood components (single blood cells, cell suspensions, blood plasma proteins). Fundamentals of static, dynamic and Raman light scattering and fluorescence-based techniques will be discussed. Topics include optics of blood, single and multiple light scattering, photon migration, laser Doppler flowmetry, optical coherence tomography, polarization sensitive measurements, formation of biospeckles and speckle blood velocimetry, in vitro and in vivo noninvasive measurements, laser and non-laser light effects on blood structure and rheology. Special emphasis will be made on new diagnostic instrumentation and clinical applications.
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