We exploited ultraprecision milling to fabricate three dimensional microfluidic structures incorporating cascaded hydrodynamic
focusing. Stable operation when varying the sample flow over three orders of magnitude was demonstrated.
Impedance detection or forward light scatter served to detect polystyrene microspheres and to differentiate red blood
cells and blood platelets.
We present a newly developed optical mammograph for concurrent diffuse optical and MR imaging of the compressed breast. A home-built MR coil allows optical measurements to be carried out along mediolateral as well as craniocaudal projections. Preliminary in-vivo experimental data are presented.
We present a newly developed scanning time-resolved optical mammograph for breast cancer detection featuring four wavelengths for enhanced spectroscopic information, up to 6 off-axis detection channels for improved depth localisation and novel attenuation and imaging optics for improved response reproducibility and photon collection efficiency. First results on the characterisation and on performance tests of this mammograph are shown.
Spectral interference caused by structured thin-film components has been used for shaping and characterization of few-cycle femtosecond laser beams. Array structures enable spatially resolved measurements of coherence and wavefront. The generation of spatially and temporally localized optical wavepackets with reflective and refractive axicons was demonstrated in theory and experiment.
Interferometric coherent anti-Stokes Raman scattering (ICARS) using non-transform-limited broadband ns-dye lasers is used for time-resolved measurements of vibrational frequency and dephasing time of solutions of bis-(dimethylamino)heptamethinium iodide and all-trans- (beta) -carotene. The results are compared with those obtainable from conventional narrowband scanning CARS. The intensity of the strongest Raman lines of all-trans-(beta) - carotene (1523 cm-1 and 1153 cm-1) decrease for a Stokes laser power density exceeding 1 GW/cm2 ((lambda) approximately equals 550 nm). ICARS reveals a simultaneous broadening of the 1523 cm-1 line from 11 cm-1 to 25 cm-1.
Ternary II-VI semiconductors, like CdSxSe1-x or ZnxCd1-xS, were prepared by thermal evaporation of binary semiconductors from a double source. The influence of substrate temperature during thin film deposition and of thermal annealing in argon atmosphere on absorption edge steepness is studied. A high absorption edge steepness is advantageous to achieve large resonant optical nonlinearities, like absorption bistability and electronic nonlinearities. The position of the absorption edge can be tuned by choosing a proper film composition. Thermally induced optical bistability is demonstrated. Electronic nonlinearities are investigated in ns- and ps-pump-probe experiments. Fast bleaching with < 60 ps relaxation time is observed at the absorption edge. The maximum bleaching coefficient for CdS0.69Se0.31 films is 1.4 cm/kW at (lambda) equals 587 nm for pumping with (lambda) equals 377 nm. Annealing the films showed no effect on the relaxation time, but the bleaching coefficient was increased by a factor of five.
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