Dr. Chenfei Hu Profile

Dr. Chenfei Hu

at Applied Materials

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Publications (6)

Proceedings Article | 13 March 2024 Poster

Flexible endomicroscopy with quantitative phase imaging

Jingyi Wang, Chenfei Hu, Yuheng Jiao, Wu You, Yu Ke, Wenlong Lu

Proceedings Volume PC12852, PC1285210 (2024) https://doi.org/10.1117/12.2688032

KEYWORDS: Finite element methods, Optical gratings, Phase shift keying, Phase imaging, Endomicroscopy, Skin, Biological imaging, Tomography, Tissues, Natural surfaces

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Proceedings Article | 13 March 2024 Presentation

Artificial confocal microscopy for deep label-free imaging

Xi Chen, Mikhail Kandel, Shenghua He, Chenfei Hu, Young Jae Lee, Kathryn Sullivan, Gregory Tracy, Hee Jung Chung, Hyun Joon Kong, Mark Anastasio, Gabriel Popescu

Proceedings Volume PC12852, PC128520V (2024) https://doi.org/10.1117/12.3001172

KEYWORDS: Confocal microscopy, Fluorescence, Laser scanners, Fluorescence microscopy, Education and training, Turbidity, Tomography, Superposition, Phase imaging, Neurons

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Proceedings Article | 5 March 2021 Open Access

Wolf phase tomography (WPT) of transparent structures using partially coherent illumination

Xi Chen, Mikhail Kandel, Chenfei Hu, Young Jae Lee, Gabriel Popescu

Proceedings Volume 11653, 1165303 (2021) https://doi.org/10.1117/12.2582903

KEYWORDS: Tomography, Refractive index, Diffraction, 3D metrology, Temporal coherence, Phase shifts, Phase imaging, Microscopes, Data acquisition, Correlation function

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Proceedings Article | 5 March 2021 Open Access

Label-free cell viability assay using phase imaging with computational specificity (PICS)

Chenfei Hu, Shenghua He, Young Jae Lee, Yuchen He, Mark Anastasio, Gabriel Popescu

Proceedings Volume 11653, 116531D (2021) https://doi.org/10.1117/12.2584228

KEYWORDS: Phase imaging, Photonic integrated circuits, Microscopy, Luminescence, Molecules, Image segmentation

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Proceedings Article | 5 March 2021 Open Access

Synthetic aperture gradient light interference microscopy (SA-GLIM) for high throughput label-free imaging

Chenfei Hu, Mikhail Kandel, Yuchen He, Young Jae Lee, Gabriel Popescu

Proceedings Volume 11653, 1165309 (2021) https://doi.org/10.1117/12.2584226

KEYWORDS: Microscopy, Synthetic aperture radar, Spatial resolution, Phase measurement, Optimization (mathematics), Objectives, Image restoration, Image resolution, Computing systems, Computer architecture

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Proceedings Article | 14 March 2018 Presentation

In vivo mapping of the cervical epithelium using multiplexed low-coherence interferometry (Conference Presentation)

Kengyeh Chu, Derek Ho, Michael Crose, Chenfei Hu, Michael DeSoto, Jennifer Peters, Amy Murtha, Daryl Wieland, Michael Zinaman, Adam Wax

Proceedings Volume 10472, 1047206 (2018) https://doi.org/10.1117/12.2290882

KEYWORDS: Interferometry, In vivo imaging, Multiplexing, Cervix, Endoscopy, Cervical cancer, Interferometers, Fiber optics, Cell biology, Optical testing

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The early detection of cervical dysplasia enables early treatment, a critical factor in cancer prevention. In the United States, cervical cancer screening is age-based and includes cervical cytology with human papilloma virus (HPV) testing with referral to colposcopy for abnormal results. Colposcopy is used to visualize changes in the appearance of the transformation zone to direct biopsies which can confirm a diagnosis of dysplasia or cancer. Directed biopsies can be limited in detection of abnormalities because they represent a small area of the transformation zone and can be limited by provider expertise. Additionally, biopsies contribute to patient discomfort and anxiety awaiting for results. We recently reported the first in vivo cervical data from angle-resolved low-coherence interferometry (a/LCI), an optical technique that measures nuclear size as a biomarker for dysplasia, which is well-suited for screening due to its high sensitivity and specificity and its non-invasive utilization. However, in order to target the single-point measurements of the a/LCI instrument, we aimed to construct a probe capable of mapping the cervical epithelium to identify the transformation zone between the ectocervical and endocervical epithelia, the location at which dysplasia is most likely to develop. We termed this complementary technology multiplexed low-coherence interferometer (m/LCI). Thirty-six parallel fiber-optic interferometers were constructed to obtain optical depth profiles using spectral-domain LCI. Light from each channel is delivered to the cervix via a 6x6 fiber-optic bundle and a custom endoscopic probe. The depth-profile from each optical channel enables the identification of the ectocervix and endocervix. A pilot study at Duke University (n=5) was followed by an ongoing clinical study at New York City Health + Hospitals/Jacobi (Bronx, New York) (current n=20, target n=50). We present the results from these first studies to demonstrate the feasibility of m/LCI as a means of identifying the transformation zone for screening of dysplasia.

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