Mr. Denis T. Murashko Profile

Denis T. Murashko

at National Research Univ. of Electronic Technology

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Proceedings Article | 20 June 2021 Presentation + Paper

Ultrashort laser radiation for biomaterial formation with carbon nanotubes in the albumin matrix

Mikhail Savelyev, Pavel Vasilevsky, Olga Kolcheva, Uliana Kurilova, Denis Murashko, Alexander Yu. Gerasimenko

Proceedings Volume 11786, 117860X (2021) https://doi.org/10.1117/12.2595769

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The effect of ultrashort laser radiation parameters on the process of biomaterial formation based on dispersed media of bovine serum albumin and carbon nanotubes was studied. It is noted that, in contrast to the use of continuous laser radiation of comparable power, the composite nanomaterial is formed when lower temperatures are reached, which provides additional advantages and a smaller change in the protein structure. This effect can also be associated with a pulse repetition rate of 80 MHz, in the interval, which is about 12.5 ns, partial cooling of the material can occur, while this effect is sufficient for the formation of a biomaterial. The hardness of this material is comparable to that of native tissue. A strong twofold change in the elasticity of such a material in comparison with drying in air indicates the formation of an inner framework of carbon nanotubes. The possibility of this effect is also confirmed by spectral studies, according to which, at the used wavelength of 810 nm, the radiation is absorbed mainly by carbon nanotubes and only as a result of heat transfer is transmitted to bovine serum albumin and is spent on water evaporation. In vitro studies of cell growth in the presence of biomaterial were carried out by quantitative (MTT test) and qualitative (microscopy) methods. It was found that the number of cells grown on the composites exceeds the number of cells in the control after 72 hours of incubation. The cells on the composites formed a monolayer, their morphology does not differ from the morphology of the cells in the control. In vitro studies indicate a positive effect of the biomaterial on cell adhesion and proliferation and, consequently, on the possibility of their use for tissue regeneration.

Proceedings Article | 30 March 2020 Presentation + Paper

Laser formation of electrically conductive nanocomposites for bioelectronic applications

N. Demidenko, A. Kuksin, D. Murashko, N. Cherepanova, A. Semak, V. Bychkov, A. Komarchev, E. Eganova, A. Dudin, A. Pavlov, A. Yu. Gerasimenko

Proceedings Volume 11349, 113490U (2020) https://doi.org/10.1117/12.2564679

KEYWORDS: Nanocomposites, Laser applications, Laser irradiation, Carbon nanotubes, Tissues, Collagen, Fiber lasers, Resistance, Biopolymers, Polymers

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Compared with traditional electronic materials (metals and semiconductors), electrically conductive biopolymers have improved compatibility with biological cells and human biological tissues. This allows creating new bioelectronic devices, for example, biosensors, drug delivery devices, 3D tissue-engineering matrix et al. A new laser method has been developed for the 3D manufacturing of electrically conductive nanocomposites with a given architecture. The architecture may be similar to the microelectronic component base (for example, the creation of microchannels between nanocomposite regions for designing transistors). A pulsed ytterbium fiber laser connected to a galvanometric scanner (laser wavelength - 1064 nm, pulse duration - 100 ns, frequency - 100 kHz, irradiation power up to 10 W) was used to form nanocomposites. By the galvanometric scanner, the focused laser beam moved along the trajectory (XYZ) specified in the software. As a result, the samples had the desired geometric 3D shape. Homogeneous dispersions of carbon nanotubes and biopolymers (albumin, collagen and chitosan amino sugar) were used as raw materials on a flexible substrate. The phase transition of the liquid dispersion of nanotubes into a solid was the main mechanism for the nanocomposites formation process. With focused laser irradiation, the temperature in the region of defects in carbon nanotubes increased, in contrast to other regions of nanotubes. As a result, the nanotubes were connected in an electrically conductive scaffold. Nanocomposites had high conductivity values of ~10 S/m, as well as high hardness of 300-500 MPa. The biocompatibility of nanocomposites has been proven in vitro и in vivo.

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