Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe
way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology,
all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells
in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel
via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that
alter vessel diameter are measured.
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