We propose the combination of polyN-isopropylacrylamide (PNIPAM) particles and optical coherence tomography (OCT) to overcome the main limitations of current nanothermometry for medical purposes. We demonstrate that PNIPAM particles can behave as temperature-sensitive contrast agents in OCT thanks to their structural phase transition at 32 °C, resulting in changes in the refractive index that make their OCT contrast temperature-dependent. Simple experiments have been conducted to demonstrate the feasibility of this approach for three-dimensional imaging of phantom tissues subjected to photothermal processes. The results included in this work constitute an alternative route towards facile incorporation of nanothermometry into the clinical world.
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