Mr. Dirk Theisen-Kunde Profile

Dirk Theisen-Kunde

CTO at Medizinisches Laserzentrum Lubeck GmbH

SPIE Involvement:

Author

Publications (40)

Proceedings Article | 11 August 2023 Paper

Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis

Nicolas Detrez, Sazgar Burhan, Paul Strenge, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12629, 126290M (2023) https://doi.org/10.1117/12.2670944

KEYWORDS: Tumors, Tissues, Brain tissue, Elastography, Connective tissue, Optical coherence, Brain, Biological samples, Optical coherence tomography, Neurosurgery

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Proceedings Article | 11 August 2023 Paper

Real-time temperature-control for cw retinal laser therapy in a clinical study

Dirk Theisen-Kunde, Claus von der Burchard, Veit Danicke, Jan-Eric Fleger, Christopher Kren, Sebastian Wittmeier, Johann Roider, Ralf Brinkmann

Proceedings Volume 12627, 1262723 (2023) https://doi.org/10.1117/12.2670839

KEYWORDS: Laser therapeutics, Temperature metrology, Laser irradiation, Fiber lasers, Continuous wave operation, Control systems, Thermoelasticity, Temperature control, Retina, Pulsed laser operation

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Proceedings Article | 11 August 2023 Paper

Clinical evaluation of thulium laser/ultrasonic aspirator combination instrument during neurosurgical tumour resection

Dirk Theisen-Kunde, Jessica Kren, Alessa Hutfilz, Matteo Mario Bonsanto, Ralf Brinkmann

Proceedings Volume 12627, 126270Z (2023) https://doi.org/10.1117/12.2670859

KEYWORDS: Laser ultrasonics, YAG lasers, Equipment, Resection, Nervous system, Surgery, Blood vessels, Neurosurgery, Laser therapeutics, Fiber lasers

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Proceedings Article | 11 August 2023 Paper

Microscope integrated real time high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation

Wolfgang Draxinger, Dirk Theisen-Kunde, Lion Schuetz, Nicolas Detrez, Paul Strenge, Maximilian Rixius, Veit Danicke, Wolfgang Wieser, Jessica Kren, Patrick Kuppler, Sonja Spar-Hess, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber

Proceedings Volume 12627, 126270W (2023) https://doi.org/10.1117/12.2670953

KEYWORDS: Microscopes, Visualization, Neurosurgery, Nervous system, Tumors, Surgery, Imaging systems, Brain, Tissues, Optical coherence tomography

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Proceedings Article | 11 August 2023 Paper

Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks

Paul Strenge, Birgit Lange, Wolfgang Draxinger, Christian Hagel, Christin Grill, Veit Danicke, Dirk Theisen-Kunde, Sonja Spahr-Hess, Matteo Bonsanto, Robert Huber, Heinz Handels, Ralf Brinkmann

Proceedings Volume 12632, 126321P (2023) https://doi.org/10.1117/12.2670907

KEYWORDS: Brain, Tumors, Optical coherence tomography, Brain tissue, White matter, Tissues, Image segmentation, Neural networks

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Proceedings Article | 9 August 2023 Paper

Small footprint SLIDE demonstrator for 40-Hz volume rate multiphoton microscopy

Dirk Theisen-Kunde, Florian Sommer, Veit Danicke, Lion Schützeck, Stefan Meyer, Christopher Kren, Maximilian Rixius, Sebastian Karpf

Proceedings Volume 12630, 126300Q (2023) https://doi.org/10.1117/12.2670881

KEYWORDS: Multiphoton microscopy, Voxels, Microscopes, Biological imaging

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Proceedings Article | 16 March 2023 Presentation + Paper

High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time

Wolfgang Draxinger, Dirk Theisen-Kunde, Lion Schützeck, Nicolas Detrez, Paul Strenge, Veit Danicke, Jessica Kren, Patrick Kuppler, Sonja Spahr-Hess, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber

Proceedings Volume 12390, 123900D (2023) https://doi.org/10.1117/12.2648505

KEYWORDS: Optical coherence tomography, Imaging systems, Microscopes, In vivo imaging, Brain, Neuroimaging, Visualization, Tissues, Brain tissue, Tumors

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Proceedings Article | 15 March 2023 Paper

Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data

Nicolas Detrez, Sazgar Burhan, Katharina Rewerts, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12381, 1238105 (2023) https://doi.org/10.1117/12.2649835

KEYWORDS: Tumors, Connective tissue, Optical coherence tomography, Viscoelasticity, Brain tissue, Tissues, Optical coherence, Elastography, Deformation, Brain

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Proceedings Article | 8 March 2023 Presentation + Paper

Phase analysis strategies for MHz OCE in the large displacement regime

Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Madita Göb, Steffen Buschschlüter, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12367, 123670Q (2023) https://doi.org/10.1117/12.2652847

KEYWORDS: Tumors, Optical coherence tomography, Biological samples, Brain tissue, Brain, Phase unwrapping, Biomechanics, Elastography, Phase contrast, Surgery

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Proceedings Article | 6 March 2023 Presentation + Paper

Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography

Paul Strenge, Birgit Lange, Wolfgang Draxinger, Christian Hagel, Christin Grill, Veit Danicke, Dirk Theisen-Kunde, Sonja Spahr-Hess, Matteo Bonsanto, Robert Huber, Heinz Handels, Ralf Brinkmann

Proceedings Volume 12368, 1236805 (2023) https://doi.org/10.1117/12.2649963

KEYWORDS: Tumors, Optical coherence tomography, Brain tissue, White matter, Education and training, Surgery, Brain, Tissues, Neural networks, Signal attenuation

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Proceedings Article | 6 March 2023 Presentation + Paper

Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate

Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Madita Göb, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

Proceedings Volume 12368, 123680F (2023) https://doi.org/10.1117/12.2648301

KEYWORDS: Tumors, Optical coherence tomography, Brain, Brain tissue, Biological samples, Tissues, Elastography, Surgery, Optical coherence, Biomechanics

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Proceedings Article | 9 December 2021 Paper

Comparison of two optical coherence tomography systems to identify human brain tumor

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, R. Brinkmann

Proceedings Volume 11924, 119240L (2021) https://doi.org/10.1117/12.2616044

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Brain, Tissue optics, Signal attenuation, System identification, Optical fibers, Scattering, Optical properties

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Proceedings Article | 7 December 2021 Paper

Laser coagulation of brain tissue at 1480 nm and 1940 nm wavelengths

Alessa Hutfilz, Dirk Theisen-Kunde, Matteo Mario Bonsanto, Ralf Brinkmann

Proceedings Volume 11919, 1191904 (2021) https://doi.org/10.1117/12.2614437

KEYWORDS: Laser tissue interaction, Tissue optics, Laser applications, Brain, Optical coherence tomography, Tissues, Natural surfaces, Laser coagulation, Laser ablation, Fiber lasers

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Proceedings Article | 7 December 2021 Paper

1.6 MHz FDML OCT for intraoperative imaging in neurosurgery

D. Theisen-Kunde, W. Draxinger, M. Bonsanto, Paul Strenge, Nicolas Detrez, R. Huber, R. Brinkmann

Proceedings Volume 11919, 119191E (2021) https://doi.org/10.1117/12.2614855

KEYWORDS: Optical coherence tomography, Tumors, Tissues, Microscopes, Surgery, Scanners, Video, Tissue optics, Interferometers, Head

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Proceedings Article | 7 December 2021 Paper

Flow controlled air puff generator towards in-situ brain tumor detection based on MHz optical coherence elastography

Nicolas Detrez, Katharina Rewerts, Moritz Matthiae, Steffen Buschschlüter, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 11919, 1191925 (2021) https://doi.org/10.1117/12.2615022

KEYWORDS: Tissues, Optical coherence tomography, Elastography, Brain, Tumors, Sensors, Coherence (optics), Tissue optics, Soft tissue optics, Natural surfaces

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

Characterization of brain tumor tissue with 1310 nm optical coherence tomography

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, R. Brinkmann

Proceedings Volume 11630, 116301T (2021) https://doi.org/10.1117/12.2578409

KEYWORDS: Tumors, Brain, Optical coherence tomography, Tissue optics, Tissues, Signal attenuation, Pathology, Optical properties

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber, R. Brinkmann

Proceedings Volume 11630, 116301S (2021) https://doi.org/10.1117/12.2578391

KEYWORDS: Optical coherence tomography, Brain, Tissues, Tumors, Surgery, Image registration, Image classification

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Proceedings Article | 5 March 2021 Presentation

Self-examination low-cost full-field OCT (SELFF-OCT) allows treatment decision for age related macular degeneration (AMD) and diabetic macular edema (DME) with high sensitivity and specificity: clinical pilot study

Helge Sudkamp, Claus von der Burchard, Moritz Moltmann, Peter Koch, Malte vom Endt, Michael Münst, Christoph Ehlken, Timo Kepp, Dirk Theisen-Kunde, Reginald Birngruber, Johann Roider, Gereon Hüttmann

Proceedings Volume 11623, 116230Z (2021) https://doi.org/10.1117/12.2583041

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Proceedings Article | 22 July 2019 Paper

Heating and optoacoustic temperature determination of cell cultures

Nicolas Detrez, Yoko Miura, Eric Seifert, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 11079, 110790W (2019) https://doi.org/10.1117/12.2527024

KEYWORDS: Temperature metrology, Optoacoustics, YAG lasers, Convection, Laser beam diagnostics, Ultrasonics, Q switched lasers, Pulsed laser operation, Thulium, Laser scanners

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Proceedings Article | 22 July 2019 Paper

Ex vivo investigation of different μs laser pulse durations for selective retina therapy

Alessa Hutfilz, Christian Burri, Christoph Meier, Ralf Brinkmann

Proceedings Volume 11079, 110791H (2019) https://doi.org/10.1117/12.2526948

KEYWORDS: Pulsed laser operation, Laser therapeutics, Retina, Eye models, Laser energy, Laser damage threshold

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Proceedings Article | 22 July 2019 Paper

Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, Christoph Meier

Proceedings Volume 11079, 1107903 (2019) https://doi.org/10.1117/12.2526720

KEYWORDS: Optical coherence tomography, Retina, Laser therapeutics, Imaging systems, Diagnostics, Pulsed laser operation, Tissue optics, Laser tissue interaction, Eye, Thermal effects

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Proceedings Article | 19 July 2019 Paper

Handheld OCT probe for intraoral diagnosis on teeth

R. Haak, M. Ahrens, H. Schneider, M. Strumpski, C. Rüger, M. Häfer, G. Hüttmann, D. Theisen-Kunde, H. Schulz-Hildebrandt

Proceedings Volume 11073, 110730W (2019) https://doi.org/10.1117/12.2527185

KEYWORDS: Optical coherence tomography, Teeth, Dental caries, Natural surfaces, Composites, Diagnostics, Endoscopes, Visualization, Dentistry, In vivo imaging

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Proceedings Article | 19 July 2019 Paper

Ex vivo and in vivo imaging of human brain tissue with different OCT systems

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, M. Bonsanto, R. Huber, R. Brinkmann

Proceedings Volume 11078, 110781C (2019) https://doi.org/10.1117/12.2526932

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SPIE Journal Paper | 3 November 2018 Open Access

Selective retina therapy: toward an optically controlled automatic dosing

Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 23, Issue 11, 115002, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.11.115002

KEYWORDS: Retina, Sensors, Visibility, Laser therapeutics, Pulsed laser operation, Eye, Algorithm development, Data acquisition, Optimization (mathematics), Modulation

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Proceedings Article | 8 March 2018 Paper

Toward automated selective retina treatment (SRT): an optical microbubble detection technique

Eric Seifert, Young-Gun Park, Dirk Theisen-Kunde, Young-Jung Roh, Ralf Brinkmann

Proceedings Volume 10474, 104740P (2018) https://doi.org/10.1117/12.2289409

KEYWORDS: Modulation, Pulsed laser operation, Signal processing, Retina, Sensors, Laser therapeutics, Data acquisition, Eye, Luminescence, Angiography

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Proceedings Article | 28 July 2017 Paper

Evaluation of an optoacoustic based gas analysing device

Janine Markmann, Birgit Lange, Dirk Theisen-Kunde, Veit Danicke, Fedor Mayorov, Sebastian Eckert, Pascal Kettmann, Ralf Brinkmann

Proceedings Volume 10411, 104110L (2017) https://doi.org/10.1117/12.2286109

KEYWORDS: Acousto-optics, Optical parametric oscillators, Tunable lasers, Optical gas detection

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Proceedings Article | 24 June 2013 Paper

Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, Ralf Brinkmann

Proceedings Volume 8803, 88030I (2013) https://doi.org/10.1117/12.2033550

KEYWORDS: Particles, Laser cutting, Q switched lasers, Continuous wave operation, Laser tissue interaction, Tissues, Laser systems engineering, Laser irradiation, Laser ablation, Statistical analysis

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Proceedings Article | 24 June 2013 Paper

Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model

Eric Seifert, Young-Jung Roh, Andreas Fritz, Young Gun Park, Seungbum Kang, Dirk Theisen-Kunde, Ralf Brinkmann

Proceedings Volume 8803, 880303 (2013) https://doi.org/10.1117/12.2033560

KEYWORDS: Retina, Laser irradiation, Automatic control, Visibility, Angiography, Laser therapeutics, Acoustics, Photodiodes, Ultrasonics, Laser damage threshold

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Proceedings Article | 24 June 2013 Paper

Investigation of water spray to reduce collateral thermal damage during laser resection of soft tissue

D. Theisen-Kunde, H. Wolken, D. Ellebrecht, V. Danicke, L. Wurster, M. Kleemann, R. Birngruber

Proceedings Volume 8803, 88030F (2013) https://doi.org/10.1117/12.2032384

KEYWORDS: Laser tissue interaction, Tissues, Clouds, Carbon dioxide, Laparoscopy, Liver, Laser vision correction, Laser therapeutics, Optical fibers, Laser induced damage

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Proceedings Article | 2 June 2011 Paper

In vivo study of partial liver resection on pigs using a 1.9 μm thulium fiber laser

D. Theisen-Kunde, H. Wolken, V. Danicke, R. Brinkmann, H. Bruch, M. Kleemann

Proceedings Volume 8092, 809211 (2011) https://doi.org/10.1117/12.889423

KEYWORDS: Fiber lasers, Liver, YAG lasers, Laser systems engineering, Tissues, Laser tissue interaction, Blood, Laser therapeutics, LASIK, Continuous wave operation

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Proceedings Article | 17 July 2009 Paper

Partial porcine kidney resection in vivo using a 1.92 µm fiber laser system

Dirk Theisen-Kunde, Sönke Tedsen, Veit Danicke, Ralf Brinkmann

Proceedings Volume 7373, 73731B (2009) https://doi.org/10.1117/12.831886

KEYWORDS: Kidney, Fiber lasers, Laser systems engineering, Tissues, Surgery, Blood, Laser tissue interaction, LASIK, Inflammation, Laser therapeutics

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Proceedings Article | 23 February 2009 Paper

Introduction of a new laser-scalpel for partial kidney resection based on 1.94 micrometer fiber laser system: initial in vivo data

Sönke Tedsen, Dirk Theisen-Kunde, Christian Doehn, Ingo Kausch, Dieter Jocham

Proceedings Volume 7161, 71611C (2009) https://doi.org/10.1117/12.806954

KEYWORDS: Kidney, Laser systems engineering, Fiber lasers, Surgery, Blood, Tissues, Laser tissue interaction, Laser therapeutics, Tumors, Laser vision correction

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The technique of nephron sparing surgery has matured significantly over the past decade and is emerging as an oncologically sound procedure for the management of renal tumors. Methods of tumor excision as well as parenchymal reconstruction in a hemostaticallly controlled field have evolved to make this procedure safer. In an attempt to find an improoved hemostatic cutting instrument we developed a 1.94 micrometer Laser-Scalpel system in a porcine model. We evaluated data for partial porcine kidney resection performed by a 1.94 micrometer Laser-Scalpel and compared the data to those of a standard HF- (High- Frequency) dissection device. In 12 pigs general anesthesia and a median laparotomy was performed to expose both kidneys. In each pig one kidney was partially resected with the Laser-Scalpel and the other side with the HF-dissection device. The first 6 pigs were euthanized immediately after the procedure. The following 6 pigs were allowed to recover and underwent 2-3 weeks later euthanasia. The final evaluation data included total resection time, blood loss, mass of dissected tissue, total ischemic time and histological examination. Mean resected kidney tissue mass was 4.75 g with the laser system and 5.57 g for the HF-dissector, respectively. Mean estimated blood loss was 22 ml for the Laser- Scalpel and 78.2 ml for the HF-dissection device. Resection time was 9.45 min for the Laser-scalpel compared to 10.16 min. No complications, specifically no postoperative bleeding, occured in any of the animals. Histological evaluation with H&E staining showed a carbonized zone of about 0.57 mm directly at the dissected edge followed by a thermal damaged zone of about 1.25 mm in width. Thereafter healthy tissue was found in all histological samples. Partial kidney resection was easily and fast performed by the use of a 1.94 micrometer Laser-Scalpel system. Hemostasis was highly sufficient, so blood loss was minimal compared to conventional HF-dissection device. Therefore the 1.94 micrometer Laser-Scalpel system is a very promising dissection device for urological surgery.

Proceedings Article | 13 July 2007 Paper

Partial kidney resection based on 1.94μm fiber laser system

D. Theisen-Kunde, S. Tedsen, K. Herrmann, V. Danicke, R. Brinkmann

Proceedings Volume 6632, 663205 (2007) https://doi.org/10.1117/12.727861

KEYWORDS: Kidney, Tissues, Fiber lasers, Laser systems engineering, Laser cutting, Continuous wave operation, Quartz, Blood, Laser tissue interaction, Tissue optics

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Proceedings Article | 27 August 2005 Paper

Hemostatic properties of a new cw 2µm laser scalpel for laparoscopic surgery

D. Theisen-Kunde, V. Ott, R. Brinkmann, R. Keller

Proceedings Volume 5863, 58630G (2005) https://doi.org/10.1117/12.633082

KEYWORDS: Arteries, Veins, YAG lasers, Laparoscopy, Laser therapeutics, Surgery, Laser vision correction, Tissues, In vivo imaging, Proteins

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Proceedings Article | 16 October 2003 Paper

Cw high-power IR laser at 2 µm for minimally invasive surgery

Dirk Theisen, Verena Ott, Heinz-Wolfram Bernd, Veit Danicke, Robert Keller, Ralf Brinkmann

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.500624

KEYWORDS: YAG lasers, Tissues, Laser cutting, Laser tissue interaction, Surgery, Liver, Laser therapeutics, Continuous wave operation, Natural surfaces, Laser ablation

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Proceedings Article | 26 October 2001 Paper

Myocardial expression of the vascular endothelial growth factor (VEGF) after endocardial laser revascularization (ELR)

Jan Rommerscheid, Dirk Theisen, G. Schmuecker, Ralf Brinkmann, R. Broll

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446529

KEYWORDS: Heart, Tissues, Arteries, Computer aided diagnosis and therapy, Surgery, Blood, Pulsed laser operation, Capillaries, LASIK, Patents

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Proceedings Article | 4 February 1999 Paper

Myocardial tissue ablation by single high-energy laser pulses for ELR and TMR

Dirk Theisen, Ralf Brinkmann, Hans-Martin Stubbe, Reginald Birngruber

Proceedings Volume 3564, (1999) https://doi.org/10.1117/12.339139

KEYWORDS: Carbon dioxide lasers, Laser ablation, Pulsed laser operation, Holmium, Heart, Laser systems engineering, Laser tissue interaction, Water, Tissues, Optical fibers

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Proceedings Article | 1 June 1998 Paper

Influence of optical aberrations on laser-induced plasma formation in water and their consequences for intraocular photodisruption

Alfred Vogel, Kester Nahen, Dirk Theisen, Reginald Birngruber, Robert Thomas, Benjamin Rockwell

Proceedings Volume 3246, (1998) https://doi.org/10.1117/12.309423

KEYWORDS: Plasma, Monochromatic aberrations, Laser energy, Diffraction, Microsurgery, Cavitation, Optical aberrations, Laser damage threshold, Pulsed laser operation, Laser optics

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Proceedings Article | 18 May 1998 Paper

Laser-induced breakdown in the eye at pulse durations from 80 ns to 100 fs

Alfred Vogel, Joachim Noack, Kester Nahen, Dirk Theisen, Reginald Birngruber, Daniel Hammer, Gary Noojin, Benjamin Rockwell

Proceedings Volume 3255, (1998) https://doi.org/10.1117/12.308220

KEYWORDS: Plasma, Electrons, Pulsed laser operation, Absorption, Laser damage threshold, Picosecond phenomena, Particles, Ultrafast phenomena, Free electron lasers, Eye

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Proceedings Article | 13 May 1998 Paper

Energy balance of optical breakdown in water

Alfred Vogel, Joachim Noack, Kester Nahen, Dirk Theisen, Stefan Busch, Ulrich Parlitz, Daniel Hammer, Gary Noojin, Benjamin Rockwell, Reginald Birngruber

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308162

KEYWORDS: Plasma, Pulsed laser operation, Cavitation, Absorption, Picosecond phenomena, Energy efficiency, Laser damage threshold, Laser scattering, Scattering, Sensors

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