This paper presents a widefield label-free plasmonic method for imaging electrical activity of pancreatic beta cells. MIN6 insulinoma cells were grown on gold surfaces modified with poly-L-lysine to promote adhesion. The results presented show synchronised electrical signals upon extracellular exposure to 10mM glucose solution. Spatiotemporal patterns of electrical activity are recorded with a sampling frequency of 100Hz and the microscopic technique offers a signal-to-noise ratio that enables measurements from an area as small as 1µm2.
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