Prof. Gooitzen M. van Dam Profile

Prof. Gooitzen M. van Dam

Professor at Univ Medical Ctr Groningen

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 13 March 2024 Presentation

Twenty years of fluorescence imaging: from image-guided surgery experimental to drug development

Gooitzen Van Dam

Proceedings Volume PC12825, PC128250W (2024) https://doi.org/10.1117/12.3021883

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Proceedings Article | 17 March 2023 Presentation

Clinical translation of a novel, dye-free perfusion imaging technique in minimally invasive surgery

Wido Heeman, Go van Dam, E. Christiaan Boerma

Proceedings Volume PC12361, PC1236102 (2023) https://doi.org/10.1117/12.2643053

KEYWORDS: Surgery, Laser speckle contrast imaging, Laparoscopy, Kidney, Intestine, Transplantation, Tissues, Spatial analysis, Ischemia, Imaging devices

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SPIE Journal Paper | 22 May 2021 Open Access

Real-time visualization of renal microperfusion using laser speckle contrast imaging

Wido Heeman, Hanno Maassen, Joost Calon, Harry van Goor, Henri Leuvenink, Gooitzen van Dam, E. Christiaan Boerma

JBO, Vol. 26, Issue 05, 056004, (May 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.5.056004

KEYWORDS: Laser speckle contrast imaging, Kidney, Ischemia, Visualization, Blood circulation, Oxygen, Nitrogen, Blood, Tissues, Hemodynamics

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Proceedings Article | 5 March 2021 Presentation

Real-time visualization of renal microperfusion using laser speckle contrast imaging

Wido Heeman, Hanno Maassen, Joost Calon, Harry Van Goor, Henri Leuvenink, Gooitzen van Dam, Christiaan Boerma

Proceedings Volume 11657, 116570F (2021) https://doi.org/10.1117/12.2577538

KEYWORDS: Laser speckle contrast imaging, Kidney, Visualization, Blood circulation, Transplantation, Temporal resolution, Surgery, Speckle, Modulation, Injuries

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Proceedings Article | 14 August 2019 Presentation

Epidermal growth factor receptor: targeted photoimmunotherapy is fluence rate dependent in-vivo (Conference Presentation)

Henriëtte de Bruijn, Wei Peng, Timo ten Hagen, Go van Dam, Jan L. Roodenburg, Max Witjes, Dominic Robinson

Proceedings Volume 11070, 110702T (2019) https://doi.org/10.1117/12.2525595

KEYWORDS: Tumors, In vivo imaging, Receptors, Photoimmunotherapy, Photodynamic therapy, Skin, Head, Neck, Cancer, Oncology

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SPIE Journal Paper | 5 August 2019 Open Access

Clinical applications of laser speckle contrast imaging: a review

Wido Heeman, Wiendelt Steenbergen, Gooitzen van Dam, E. Christiaan Boerma

JBO, Vol. 24, Issue 08, 080901, (August 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.8.080901

KEYWORDS: Laser speckle contrast imaging, Speckle, Tissues, Blood circulation, Surgery, Speckle pattern, Blood, Biomedical optics, Sensors, Tissue optics

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SPIE Journal Paper | 5 October 2018 Open Access

Perspective review of what is needed for molecular-specific fluorescence-guided surgery

Brian Pogue, Eben Rosenthal, Samuel Achilefu, Gooitzen van Dam

JBO, Vol. 23, Issue 10, 100601, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.100601

KEYWORDS: Surgery, Tumors, Cancer, Imaging systems, In vivo imaging, Luminescence, Tissues, Colorectal cancer, Pancreatic cancer, Pathology

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Molecular image-guided surgery has the potential for translating the tools of molecular pathology to real-time guidance in surgery. As a whole, there are incredibly positive indicators of growth, including the first United States Food and Drug Administration clearance of an enzyme-biosynthetic-activated probe for surgery guidance, and a growing number of companies producing agents and imaging systems. The strengths and opportunities must be continued but are hampered by important weaknesses and threats within the field. A key issue to solve is the inability of macroscopic imaging tools to resolve microscopic biological disease heterogeneity and the limitations in microscopic systems matching surgery workflow. A related issue is that parsing out true molecular-specific uptake from simple-enhanced permeability and retention is hard and requires extensive pathologic analysis or multiple in vivo tests, comparing fluorescence accumulation with standard histopathology and immunohistochemistry. A related concern in the field is the over-reliance on a finite number of chosen preclinical models, leading to early clinical translation when the probe might not be optimized for high intertumor variation or intratumor heterogeneity. The ultimate potential may require multiple probes, as are used in molecular pathology, and a combination with ultrahigh-resolution imaging and image recognition systems, which capture the data at a finer granularity than is possible by the surgeon. Alternatively, one might choose a more generalized approach by developing the tracer based on generic hallmarks of cancer to create a more “one-size-fits-all” concept, similar to metabolic aberrations as exploited in fluorodeoxyglucose - positron emission tomography (FDG-PET) (i.e., Warburg effect) or tumor acidity. Finally, methods to approach the problem of production cost minimization and regulatory approvals in a manner consistent with the potential revenue of the field will be important. In this area, some solid steps have been demonstrated in the use of fluorescent labeling commercial antibodies and separately in microdosing studies with small molecules.

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Proceedings Article | 28 July 2017 Paper

Fluorescently labeled bevacizumab in human breast cancer: defining the classification threshold

Maximilian Koch, Johannes de Jong, Jürgen Glatz, Panagiotis Symvoulidis, Laetitia Lamberts, Arthur L. L. Adams, Mariëtte E. G. Kranendonk, Anton G. T. Terwisscha van Scheltinga, Michaela Aichler, Liesbeth Jansen, Jakob de Vries, Marjolijn Lub-de Hooge, Carolien Schröder, Annelies Jorritsma-Smit, Matthijs Linssen, Esther de Boer, Bert van der Vegt, Wouter Nagengast, Sjoerd Elias, Sabrina Oliveira, Arjen Witkamp, Willem P. Th. M. Mali, Elsken Van der Wall, P. Beatriz Garcia-Allende, Paul van Diest, Elisabeth G. E. de Vries, Axel Walch, Gooitzen van Dam, Vasilis Ntziachristos

Proceedings Volume 10411, 104110F (2017) https://doi.org/10.1117/12.2286062

KEYWORDS: Breast cancer, Imaging systems, Medical imaging, Luminescence

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SPIE Journal Paper | 21 April 2014 Open Access

Video-rate optical flow corrected intraoperative functional fluorescence imaging

Maximilian Koch, Jürgen Glatz, Vladimir Ermolayev, Elisabeth de Vries, Gooitzen van Dam, Karl-Hans Englmeier, Vasilis Ntziachristos

JBO, Vol. 19, Issue 04, 046012, (April 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.4.046012

KEYWORDS: Fluorescence lifetime imaging, Tissues, Luminescence, Imaging systems, Collagen, Confocal microscopy, Tissue optics, Reflectivity, Image resolution, Signal detection

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Proceedings Article | 10 February 2011 Paper

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Daniel Razansky, Niels Harlaar, Jan-Luuk Hillebrands, Adrian Taruttis, Eva Herzog, Clark Zeebregts, Goitzen van Dam, Vasilis Ntziachristos

Proceedings Volume 7899, 789905 (2011) https://doi.org/10.1117/12.875271

KEYWORDS: Tomography, Tissues, Signal detection, Luminescence, Visualization, Scattering, Transducers, Optical tomography, Image resolution, Data acquisition

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SPIE Journal Paper | 1 November 2010 Open Access

Current concepts and future perspectives on surgical optical imaging in cancer

Vasilis Ntziachristos, Jung Sun Yoo, Gooitzen van Dam

JBO, Vol. 15, Issue 06, 066024, (November 2010) https://doi.org/10.1117/12.10.1117/1.3523364

KEYWORDS: Luminescence, Tissues, Tumors, Imaging systems, Optical imaging, Surgery, Lymphatic system, Cancer, Optical coherence tomography, Near infrared

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