In this presentation, we introduce a novel imaging system that combines optical coherence tomography (OCT) and angle-resolved low-coherence interferometry (a/LCI) for enhanced detection of esophageal dysplasia. By integrating wide area imaging with high-resolution OCT and depth-resolved a/LCI measurements, we aim to provide a sensitive and specific screening method. This innovative approach overcomes the limitations of traditional techniques and enables real-time imaging guidance for accurate coverage of at-risk tissue surfaces. Our pilot clinical study shows promising results, suggesting that this combined system holds great potential in improving early detection and diagnosis of esophageal dysplasia in patients at risk.
We present a dual-modality instrument that utilizes a paddle-shaped probe to conduct OCT imaging and a/LCI nuclear size measurements simultaneously to provide both structural and functional information in a single device during an endoscopic procedure. The probe is 3D printed using biocompatible material to deliver both modalities to the same location on the esophageal epithelium as a means to detect pre-cancerous tissues. We will present an update of our current clinical study at the University of North Carolina Center for Esophageal Diseases and Swallowing (UNC CEDAS) with a target of 40 total patients with and without esophageal dysplasia.
We present a machine learning method for the detection and staging of cervical dysplasia tissue using a convolutional neural network (CNN)-based architecture. Depth-resolved angular scattering measurements collected from two clinical trials consisting of 6660 and 1600 depth scans were used as training and validation sets separately. Our results demonstrated high sensitivity and specificity for classifying cervical dysplasia at a hundredfold faster processing time compared with the traditional Mie-theory inverse light scattering analysis (ILSA) method, offering a promising approach for a/LCI in the clinic for assessing cervical dysplasia.
Angle-resolved low-coherence interferometry (a/LCI) is an optical technique which uses inverse models of light scattering to predict the size and density of cell nuclei, a significant biomarker of precancer. In recent years, substantial progress has occurred in a/LCI technology, particularly in novel instrumentation for the detection of dysplasia in the cervix and the esophagus. This abstract summarizes recent developments in a/LCI, with a focus on developments over the previous four years. Clinical studies in the cervix, novel optical instrumentation addressing the cervix and esophagus, and novel applications related to Alzheimer’s disease are discussed.
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