Dr. Hisataka Kobayashi Profile

Dr. Hisataka Kobayashi

Chief Scientist at National Cancer Institute

SPIE Involvement:

Conference Program Committee | Author

Publications (21)

Proceedings Article | 7 March 2022 Presentation

Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang, Hisataka Kobayashi, Yu Chen, Shulian Wu, Feng Yan, Chen Wang, Hui Li, Ryuhei Okada, Yuhong Fang, Tadanobu Nagaya

Proceedings Volume PC11961, PC1196106 (2022) https://doi.org/10.1117/12.2607879

KEYWORDS: Photoimmunotherapy, Optical imaging, Tumors, Blood vessels, Optical coherence tomography, Near infrared, Blood, 3D image processing, Luminescence, 3D acquisition

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Proceedings Article | 5 March 2021 Presentation

Near infrared photoimmunotherapy for cancer; New targets on cancer and immune-suppressive cells

Hisataka Kobayashi

Proceedings Volume 11660, 1166003 (2021) https://doi.org/10.1117/12.2577639

KEYWORDS: Cancer, Near infrared, Photoimmunotherapy, Tumors, Cell death, Oncology, Neck, Monoclonal antibodies, Molecules, Head

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Proceedings Article | 1 April 2020 Paper

Near infrared photoimmunotherapy: a new type of immune theranostic technology for cancer

Hisataka Kobayashi

Proceedings Volume 11362, 113620S (2020) https://doi.org/10.1117/12.2554486

KEYWORDS: Cancer, Tumors, Near infrared, Imaging systems, Photoimmunotherapy, Phototherapy, Receptors, Endoscopy, Clinical trials, Head

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Proceedings Article | 4 March 2019 Open Access

Near infrared photoimmunotherapy for cancer: enhanced anti-tumor immunity when combined with immuno-activation therapies (Conference Presentation)

Hisataka Kobayashi

Proceedings Volume 10893, 1089302 (2019) https://doi.org/10.1117/12.2506637

KEYWORDS: Cancer, Near infrared, Tumors, Photoimmunotherapy, Therapeutics, Cell death, Tumor growth modeling, Monoclonal antibodies, Molecules, Clinical trials

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Proceedings Article | 24 April 2017 Presentation

Spatially selective depleting tumor-associated negative regulatory T-(Treg) cells with near infrared photoimmunotherapy (NIR-PIT): A new cancer immunotherapy (Conference Presentation)

Hisataka Kobayashi

Proceedings Volume 10079, 1007902 (2017) https://doi.org/10.1117/12.2249932

KEYWORDS: Near infrared, Cancer, Photoimmunotherapy, Monoclonal antibodies, Molecules, Cell death, Tumors, Dysprosium, Modulation, Therapeutics

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Proceedings Article | 19 April 2017 Presentation

Near infrared photoimmunotherapy rapidly elicits specific host immunity against cancer cells (Conference Presentation)

Hisataka Kobayashi

Proceedings Volume 10065, 1006507 (2017) https://doi.org/10.1117/12.2249943

KEYWORDS: Tumors, Biomedical optics, Current controlled current source, Cancer, Near infrared, Photoimmunotherapy, Cell death, Monoclonal antibodies, Molecules, Acquisition tracking and pointing

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Proceedings Article | 19 April 2017 Presentation

Sprayable enzyme-activatable fluorescent probes: kinetic mapping using dynamic fluorescence imaging can help detecting tiny cancer foci (Conference Presentation)

Hisataka Kobayashi

Proceedings Volume 10049, 100490O (2017) https://doi.org/10.1117/12.2249934

KEYWORDS: Tumors, Luminescence, Cancer, Tissues, Surgery, Signal processing, Tissue optics, Optical imaging, Endoscopy, Biological research

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Proceedings Article | 19 April 2017 Presentation

Real-time monitoring the distribution of antibody-photo-absorber conjugates during photoimmunotherapy in vivo (Conference Presentation)

Qinggong Tang, Jonathan Lin, Tadanobu Nagaya, Yi Liu, Hisataka Kobayashi, Yu Chen

Proceedings Volume 10047, 100470V (2017) https://doi.org/10.1117/12.2253355

KEYWORDS: Tumors, Luminescence, Imaging systems, In vivo imaging, Cancer, Near infrared, Cell death, Photoimmunotherapy, Monoclonal antibody therapy, Monoclonal antibodies

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Proceedings Article | 27 April 2016 Presentation

Mechanism of eliciting host immunity against cancer cells treated with silica-phthalocyanine-based near infrared photoimmunotherapy (Conference Presentation)

Hisataka Kobayashi

Proceedings Volume 9723, 972302 (2016) https://doi.org/10.1117/12.2208812

KEYWORDS: Cancer, Near infrared, Photoimmunotherapy, Cell death, Microscopy, Monoclonal antibodies, Molecules, Phase contrast, Tumors, Acquisition tracking and pointing

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SPIE Journal Paper | 24 September 2014 Open Access

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography

Chia-Pin Liang, Takahito Nakajima, Rira Watanabe, Kazuhide Sato, Peter Choyke, Yu Chen, Hisataka Kobayashi

JBO, Vol. 19, Issue 09, 098004, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.9.098004

KEYWORDS: Tumors, Blood, Optical coherence tomography, Blood vessels, Photoimmunotherapy, Tissues, Hemodynamics, Near infrared, Cancer, In vivo imaging

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Proceedings Article | 14 April 2014 Paper

Investigation of dynamic morphological changes of cancer cells during photoimmuno therapy (PIT) by low-coherence quantitative phase microscopy

Mikako Ogawa, Toyohiko Yamauchi, Hidenao Iwai, Peter Choyke, Hisataka Kobayashi, Yasuhiro Magata

Proceedings Volume 8931, 893113 (2014) https://doi.org/10.1117/12.2036944

KEYWORDS: Cancer, Photodynamic therapy, Luminescence, Near infrared, Microscopy, Cell death, Microscopes, Molecules, Photonics, Optical filters

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SPIE Journal Paper | 10 June 2013 Open Access

Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging

Kohei Sano, Takahito Nakajima, Towhid Ali, Derek Bartlett, Peter Choyke, Anna Wu, Insook Kim, Chang Paik, Hisataka Kobayashi

JBO, Vol. 18, Issue 10, 101304, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.101304

KEYWORDS: Luminescence, Tumors, Kidney, Liver, Indocyanine green, In vivo imaging, Molecular imaging, Cancer, Bandpass filters, Proteins

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Proceedings Article | 5 February 2011 Paper

Target cell specific antibody based photosensitizers for photodynamic therapy

Lauren Rosenblum, Nicole Morgan, Thomas Pohida, John Kakareka, Hisataka Kobayashi, Makoto Mitsunaga, Peter Choyke

Proceedings Volume 7910, 791008 (2011) https://doi.org/10.1117/12.873887

KEYWORDS: Picosecond phenomena, Photodynamic therapy, Luminescence, Photosensitizer targeting, Cancer, Cell death, Rhodamine B, Molecules, Proteins, Monoclonal antibodies

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Proceedings Article | 17 February 2010 Paper

Microdistribution of fluorescently-labeled monoclonal antibody in a peritoneal dissemination model of ovarian cancer

Chang Paik, Nobuyuki Kosaka, Mikako Ogawa, Peter Choyke, David Paik, Hisataka Kobayashi

Proceedings Volume 7576, 757604 (2010) https://doi.org/10.1117/12.842090

KEYWORDS: Tumors, Luminescence, Microscopy, Ovarian cancer, Monoclonal antibodies, Cancer, Therapeutic antibodies, Linear filtering, Tumor growth modeling, Statistical analysis

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Proceedings Article | 21 February 2009 Paper

Activatable optical imaging probes with various fluorophore-quencher combinations

Hisataka Kobayashi, Nobuyuki Kosaka, Yasuteru Urano, Peter Choyke, Mikako Ogawa

Proceedings Volume 7190, 71900Z (2009) https://doi.org/10.1117/12.808326

KEYWORDS: Luminescence, Tumors, In vivo imaging, Molecules, Molecular imaging, Cancer, Lung, Imaging systems, Signal detection, Fluorescence resonance energy transfer

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Proceedings Article | 21 February 2009 Paper

Fluorescence in vivo imaging of live tumor cells with pH-activatable targeted probes via receptor-mediated endocytosis

Hisataka Kobayashi, Yoshinori Koyama, Yasuteru Urano, Daisuke Asanuma, Tetsuo Nagano, Yukihiro Hama

Proceedings Volume 7190, 71901A (2009) https://doi.org/10.1117/12.809938

KEYWORDS: Tumors, Luminescence, In vivo imaging, Mouse models, Lung, Visualization, Tissues, Cancer, Endoscopy, Imaging systems

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SPIE Journal Paper | 1 January 2009 Open Access

Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer

Nobuyuki Kosaka, Mikako Ogawa, Michelle Longmire, Peter Choyke, Hisataka Kobayashi

JBO, Vol. 14, Issue 01, 014023, (January 2009) https://doi.org/10.1117/12.10.1117/1.3083449

KEYWORDS: Tumors, Luminescence, In vivo imaging, Ovarian cancer, Microscopy, Optical imaging, Tumor growth modeling, Cancer, Receptors, Target detection

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Proceedings Article | 22 February 2008 Paper

Multi-excitation near infrared (NIR) spectral fluorescence imaging using organic fluorophores

Peter Choyke, Yukihiro Hama, Yoshinori Koyama, Hisataka Kobayashi, Tristan Barrett

Proceedings Volume 6867, 686703 (2008) https://doi.org/10.1117/12.762380

KEYWORDS: Near infrared, Luminescence, In vivo imaging, Tumors, Lymphatic system, Optical filters, Molecules, Receptors, Image filtering, Cancer

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SPIE Journal Paper | 1 September 2007 Open Access

D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green

Yukihiro Hama, Yasuteru Urano, Yoshinori Koyama, Peter Choyke, Hisataka Kobayashi

JBO, Vol. 12, Issue 05, 051501, (September 2007) https://doi.org/10.1117/12.10.1117/1.2779351

KEYWORDS: Luminescence, Cancer, In vivo imaging, Ovarian cancer, Receptors, Tumors, Molecules, Flow cytometry, Microscopy, Proteins

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SPIE Journal Paper | 1 May 2007 Open Access

Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging

Yukihiro Hama, Yoshinori Koyama, Peter Choyke, Hisataka Kobayashi

JBO, Vol. 12, Issue 03, 034016, (May 2007) https://doi.org/10.1117/12.10.1117/1.2745306

KEYWORDS: Liver, Proteins, In vivo imaging, Near infrared, Optical imaging, Skin, Molecules, Image enhancement, Visualization, Optical tracking

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Proceedings Article | 14 February 2007 Paper

Whole-body multicolor spectrally resolved fluorescence imaging for development of target-specific optical contrast agents using genetically engineered probes

Yoshinori Koyama, Tristan Barrett, Yukihiro Hama, Peter Choyke, Yasuteru Urano, Hisataka Kobayashi

Proceedings Volume 6449, 644914 (2007) https://doi.org/10.1117/12.724241

KEYWORDS: Luminescence, Tumors, Cancer, Lung, Receptors, Fluorescent proteins, In vivo imaging, Target detection, Animal model studies, Control systems

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Showing 5 of 21 publications

Conference Committee Involvement (30)

Biophotonics and Immune Responses XX

25 January 2025 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications XI

25 January 2025 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XVI

25 January 2025 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV

30 January 2024 | San Francisco, California, United States

Biophotonics and Immune Responses XIX

28 January 2024 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications X

27 January 2024 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV

31 January 2023 | San Francisco, California, United States

Biophotonics and Immune Responses XVIII

30 January 2023 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications IX

28 January 2023 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VIII

22 January 2022 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII

6 March 2021 | Online Only, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VII

6 March 2021 | Online Only, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII

4 February 2020 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VI

1 February 2020 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI

4 February 2019 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications V

2 February 2019 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X

29 January 2018 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications IV

27 January 2018 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

30 January 2017 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications III

28 January 2017 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

15 February 2016 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications II

13 February 2016 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII

9 February 2015 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications

7 February 2015 | San Francisco, California, United States