Ms. Hongjing Sun Profile

Hongjing Sun

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Publications (16)

Proceedings Article | 13 March 2024 Presentation

A multichannel device for continuous singlet oxygen luminescent dosimetry (CSOLD) in photodynamic therapy

Baozhu Lu, Weibing Yang, Faith Cherop, Hongjing Sun, Robert Hadfield, Brian Wilson, Timothy Zhu

Proceedings Volume 12823, 1282306 (2024) https://doi.org/10.1117/12.3005185

KEYWORDS: Oxygen, Photodynamic therapy, Dosimetry, Signal detection, Picosecond phenomena, Tissues, Luminescence, In vivo imaging, In vitro testing, Algorithm development

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Proceedings Article | 13 March 2024 Presentation + Paper

Enhanced photodynamic therapy delivery for malignant pleural mesothelioma using 3D-printed models and optical scanning technology

Dennis Sourvanos, Hongjin Sun, Timothy Zhu, Andreea Dimofte, Weibing Yang, Theresa Busch, Keith Cengel, Brook Byrd, Rodrigo Neiva, Joseph Fiorellini

Proceedings Volume 12823, 1282309 (2024) https://doi.org/10.1117/12.3005184

KEYWORDS: 3D modeling, Photodynamic therapy, 3D printing, Optical scanning, Tumor growth modeling, Mesothelioma, Lung, Dosimetry, Computed tomography, Anatomy

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Proceedings Article | 13 March 2024 Presentation + Paper

Validation of a real-time navigation system for pleural photodynamic therapy with 3D-printed lung phantom and various optical properties

Hongjing Sun, Dennis Sourvanos, Brook Byrd, Timothy Zhu

Proceedings Volume 12823, 1282307 (2024) https://doi.org/10.1117/12.3002927

KEYWORDS: Photodynamic therapy, Navigation systems, Infrared cameras, Visualization, Optical properties, Light scattering, Sensors, Lung, 3D scanning, Cameras

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Proceedings Article | 13 March 2024 Presentation + Paper

Simulation of the singlet oxygen distribution for Photofrin-mediated photodynamic therapy using patient-specific modeling

Hongjing Sun, Rozhin Penjweini, Michele Kim, Timothy Zhu

Proceedings Volume 12823, 1282304 (2024) https://doi.org/10.1117/12.3002916

KEYWORDS: Photodynamic therapy, Oxygen, Data modeling, Dosimetry, Modeling, Computer simulations, Interpolation, Tissues, Infrared imaging, Navigation systems

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Proceedings Article | 13 March 2024 Presentation + Paper

A comparison of multichannel singlet oxygen luminescence dosimetry (MSOLD) and singlet oxygen explicit dosimetry (SOED)

Weibing Yang, Dennis Sourvanos, Baozhu Lu, Hongjing Sun, Madelyn Johnson, Brain Wilson, Robert Hadfield, Timothy Zhu

Proceedings Volume 12823, 1282305 (2024) https://doi.org/10.1117/12.3003421

KEYWORDS: Oxygen, Photodynamic therapy, Dosimetry, Fluorescence, Spectroscopy, Singular value decomposition, Photobleaching, Luminescence, Liquids, In vitro testing

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Proceedings Article | 13 March 2024 Presentation + Paper

Tissue optical properties correction of multispectral singlet oxygen luminescent dosimetry (MSOLD) for Photofrin-mediated photodynamic therapy

Weibing Yang, Madelyn Johnson, Baozhu Lu, Dennis Sourvanos, Hongjing Sun, Brian Wilson, Robert Hadfield, Timothy Zhu

Proceedings Volume 12823, 1282303 (2024) https://doi.org/10.1117/12.3003076

KEYWORDS: Oxygen, Monte Carlo methods, Optical properties, Signal detection, Absorption, Photodynamic therapy, Luminescence, Singular value decomposition

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SPIE Journal Paper | 13 January 2024 Open Access

Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy

Hongjing Sun, Yihong Ong, Weibing Yang, Dennis Sourvanos, Andreea Dimofte, Theresa M. Busch, Sunil Singhal, Keith A. Cengel, Timothy C. Zhu

JBO, Vol. 29, Issue 01, 018001, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.018001

KEYWORDS: Photodynamic therapy, Dosimetry, Picosecond phenomena, Fluorescence, Optical properties, Tissues, Navigation systems, Sensors, Optical testing, Singular value decomposition

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SignificancePhotodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce an innovative eight-channel PDT dose dosimetry system capable of concurrently measuring light fluence and PS concentration during treatment.AimWe aim to develop and evaluate an eight-channel PDT dose dosimetry system for simultaneous measurement of light fluence and PS concentration. By addressing uncertainties due to tissue variations, the system enhances accurate PDT dosimetry for improved treatment outcomes.ApproachThe study positions eight isotropic detectors strategically within the pleural cavity before PDT. These detectors are linked to bifurcated fibers, distributing signals to both a photodiode and a spectrometer. Calibration techniques are applied to counter tissue-related variations and improve measurement accuracy. The fluorescence signal is normalized using the measured light fluence, compensating for variations in tissue properties. Measurements were taken in 78 sites in the pleural cavities of 20 patients.ResultsObservations reveal minimal Photofrin concentration variation during PDT at each site, juxtaposed with significant intra- and inter-patient heterogeneities. Across 78 treated sites in 20 patients, the average Photofrin concentration for all 78 sites is 4.98 μM, with a median concentration of 4.47 μM. The average PDT dose for all 78 sites is 493.17 μMJ/cm2, with a median dose of 442.79 μMJ/cm2. A significant variation in PDT doses is observed, with a maximum difference of 3.1 times among all sites within one patient and a maximum difference of 9.8 times across all patients.ConclusionsThe introduced eight-channel PDT dose dosimetry system serves as a valuable real-time monitoring tool for light fluence and PS concentration during PDT. Its ability to mitigate uncertainties arising from tissue properties enhances dosimetry accuracy, thus optimizing treatment outcomes and bolstering the effectiveness of PDT in cancer therapy.

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Proceedings Article | 14 March 2023 Presentation + Paper

PDT light fluence phantom modeling of the human pleural cavity: a proof-of-concept pre-clinical study

Dennis Sourvanos, Hongjing Sun, Keith Cengel, Joseph Fiorellini, Timothy Zhu

Proceedings Volume 12359, 1235909 (2023) https://doi.org/10.1117/12.2654485

KEYWORDS: Photodynamic therapy, 3D modeling, Modeling, Medicine, Computed tomography, Adhesives, 3D acquisition, Scanners, Instrument modeling, Chest

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Proceedings Article | 14 March 2023 Presentation + Paper

Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for PHOTOFRIN-mediated photodynamic therapy

Weibing Yang, Vivek Rastogi, Hongjing Sun, Dvij Sharma, Brian Wilson, Robert Hadfield, Timothy Zhu

Proceedings Volume 12359, 1235908 (2023) https://doi.org/10.1117/12.2652590

KEYWORDS: Oxygen, Dosimetry, Photodynamic therapy, Signal intensity, Spectroscopy, Indium gallium arsenide, Phosphorescence

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Proceedings Article | 14 March 2023 Poster + Paper

A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system

Hongjing Sun, Dennis Sourvanos, Mary Potasek, Gene Parilov, Carl Beesonk, Timothy Zhu

Proceedings Volume 12359, 123590C (2023) https://doi.org/10.1117/12.2650456

KEYWORDS: Navigation systems, Photodynamic therapy, Lung, Light sources, 3D acquisition, Infrared imaging, Infrared cameras, Imaging systems, Algorithm development, 3D scanning

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Proceedings Article | 14 March 2023 Presentation + Paper

Evaluation of fractionated PHOTOFRIN-mediated photodynamic therapy using different light fluences with Reactive Oxygen Species Explicit Dosimetry (ROSED)

Hongjing Sun, Vivek Rastogi, Timothy Zhu

Proceedings Volume 12359, 1235906 (2023) https://doi.org/10.1117/12.2650434

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Light sources and illumination, Dosimetry, Animal model studies, Oxygenation, Toxicity, Tissues, Skin

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Proceedings Article | 14 March 2023 Presentation + Paper

A Monte Carlo simulation for moving light source in intracavity PDT

Evgueni Parilov, Karl Beeson, Mary Potasek, Timothy Zhu, Hongjing Sun, Dennis Sourvanos

Proceedings Volume 12359, 1235903 (2023) https://doi.org/10.1117/12.2649538

KEYWORDS: Light sources, Voxels, Photodynamic therapy, Monte Carlo methods, Radiotherapy, Analytics, Tumors, Surgery, Dosimetry, Tissues

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Proceedings Article | 4 March 2022 Presentation + Paper

Reactive oxygen species explicit dosimetry (ROSED) for fractionated photofrin-mediated photodynamic therapy (PDT)

Hongjing Sun, Yi Hong Ong, Timothy Zhu

Proceedings Volume 11940, 1194007 (2022) https://doi.org/10.1117/12.2609969

KEYWORDS: Photodynamic therapy, Tumors, Oxygen, Tissue optics, Optical testing, Radiation oncology

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Proceedings Article | 4 March 2022 Paper

Validation of multispectral singlet oxygen luminescence dosimetry (MSOLD) for photofrin-mediated photodynamic therapy

Ryan Hall Morales, Hongjing Sun, Yi Hong Ong, Timothy Zhu

Proceedings Volume 11940, 119400J (2022) https://doi.org/10.1117/12.2609937

KEYWORDS: Picosecond phenomena, Oxygen, Signal detection, Sensors, Photodynamic therapy, Liquids, Calibration, Indium gallium arsenide, Luminescence, Tissues

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Proceedings Article | 4 March 2022 Presentation + Paper

Real-time PDT dose dosimetry for pleural photodynamic therapy

Timothy Zhu, Hongjing Sun, Yi-Hong Ong, Ryan Hall Morales, Andreea Dimofte, Theresa Busch, Sunil Singhal, Keith Cengel

Proceedings Volume 11940, 1194002 (2022) https://doi.org/10.1117/12.2612188

KEYWORDS: Photodynamic therapy, Picosecond phenomena, Navigation systems, Optical properties, Luminescence, Tissue optics, Sensors, Optical testing, Infrared imaging, Surgery

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Proceedings Article | 30 March 2021 Presentation + Paper

Cherenkov imaging for total skin electron therapy: an evaluation of dose uniformity

Timothy Zhu, Yihong Ong, Hongjing Sun, Weili Zhong, Tianshun Miao, Andreea Dimofte, Petr Bruza, Amit Maity, John Plastaras, Ima Paydar, Lei Dong, Brian Pogue

Proceedings Volume 11628, 116280R (2021) https://doi.org/10.1117/12.2583939

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Showing 5 of 16 publications

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