We suggest a method to monitor dehydration status using the change of albumin concentration measured from short wavelength infrared (SWIR) in-vivo spectrum. Absorption spectra were measured on swine skin using Fourier transform infrared spectroscopy based system, while dehydration and rehydration of the swine subject were induced by intravenous infusion of mannitol and saline solutions, respectively. The effective water path length and the amount of albumin absorption were regressed from the measured skin spectrum. Then, albumin concentration was acquired by normalizing albumin absorption by water path length. Experimental results showed that albumin concentration increases during dehydration period and decreases during rehydration period, which indicates the possibility of SWIR spectroscopy as a means for optical hydration status monitoring.
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