Dr. Jesse H. Lam Profile

Dr. Jesse H. Lam

at Beckman Laser Institute Korea

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Publications (5)

SPIE Journal Paper | 31 July 2023 Open Access

Spectral correction of light emitting diodes enables accurate hydration ratio calculation using narrowband diffuse reflectance spectroscopy

Jesse Lam, Jeonghun Kim, Kelsey Tu, Dongbin Kim, Sehwan Kim

JBO, Vol. 28, Issue 07, 075005, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.7.075005

KEYWORDS: Light emitting diodes, Photodiodes, Tissues, Emulsions, Chromophores, Reflectivity, Simulations, Diffuse reflectance spectroscopy, Spectroscopy, Crosstalk

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Proceedings Article | 2 March 2022 Presentation + Paper

Broad-bandwidth frequency-domain near-infrared spectroscopy system on a chip

Siavash Yazdi, Saba Mohammadi, Shashikant Lahade, Alex Beck, Timothy Quang, Jesse Lam, Thomas O'Sullivan, Michael Green

Proceedings Volume 11956, 1195603 (2022) https://doi.org/10.1117/12.2608961

KEYWORDS: Tissue optics, Tissues, Optical properties, Sensors, Integrated circuits, Near infrared spectroscopy, Integrated circuit design, Biomedical optics and medical imaging

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SPIE Journal Paper | 13 August 2021 Open Access

Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics

Jesse Lam, Brian Hill, Timothy Quang, Robert Amelard, Sehwan Kim, Hossein Yazdi, Robert Warren, Kyle Cutler, Bruce Tromberg

JBO, Vol. 26, Issue 08, 085002, (August 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.8.085002

KEYWORDS: Tissues, Hemodynamics, Tissue optics, Data acquisition, Diffuse optical spectroscopy, Oxygen, Optical properties, Imaging systems, Semiconductor lasers, In vivo imaging

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Significance: Diffuse optical spectroscopic imaging (DOSI) is a versatile technology sensitive to changes in tissue composition and hemodynamics and has been used for a wide variety of clinical applications. Specific applications have prompted the development of versions of the DOSI technology to fit specific clinical needs. This work describes the development and characterization of a multi-modal DOSI (MM-DOSI) system that can acquire metabolic, compositional, and pulsatile information at multiple penetration depths in a single hardware platform. Additionally, a 3D tracking system is integrated with MM-DOSI, which enables registration of the acquired data to the physical imaging area. Aim: We demonstrate imaging, layered compositional analysis, and metabolism tracking capabilities using a single MM-DOSI system on optical phantoms as well as in vivo human tissue. Approach: We characterize system performance with a silicone phantom containing an embedded object. To demonstrate multi-layer sensitivity, we imaged human calf tissue with a 4.8-mm skin-adipose thickness. Human thenar tissue was also measured using a combined broadband DOSI and continuous-wave near-infrared spectroscopy method (∼15 Hz acquisition rate). Results: High-resolution optical property maps of absorption (μa) and reduced scattering (μs ′ ) were recovered on the phantom by capturing over 1000 measurement points in under 5 minutes. On human calf tissue, we show two probing depth layers have significantly different (p < 0.001) total-hemo/myoglobin and μs ′ composition. On thenar tissue, we calculate tissue arterial oxygen saturation, venous oxygen saturation, and tissue metabolic rate of oxygen consumption during baseline and after release of an arterial occlusion. Conclusions: The MM-DOSI can switch between collection of broadband spectra, high-resolution images, or multi-depth hemodynamics without any hardware reconfiguration. We conclude that MM-DOSI enables acquisition of high resolution, multi-modal data consolidated in a single platform, which can provide a more comprehensive understanding of tissue hemodynamics and composition for a wide range of clinical applications.

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SPIE Journal Paper | 5 April 2017 Open Access

Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy

Hossein Yazdi, Thomas O'Sullivan, Anaïs Leproux, Brian Hill, Amanda Durkin, Seraphim Telep, Jesse Lam, Siavash Yazdi, Alice Police, Robert Carroll, Freddie Combs, Tomas Strömberg, Arjun Yodh, Bruce Tromberg

JBO, Vol. 22, Issue 04, 045003, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.045003

KEYWORDS: Tumors, Tissues, Blood circulation, Tissue optics, Optical properties, Absorption, Breast cancer, Spectroscopy, Mode conditioning cables, Breast

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Proceedings Article | 5 March 2015 Paper

Broadband characterization of tissue simulating phantoms using a supercontinuum laser in a scanning diffuse optical spectroscopy instrument

Albert Cerussi, Kevin Conde, Jesse Lam, Vaibhav Verma

Proceedings Volume 9319, 93191Z (2015) https://doi.org/10.1117/12.2078436

KEYWORDS: Calibration, Optical properties, Monte Carlo methods, Scattering, Tissue optics, Near infrared, Tissues, Absorption, Sensors, Mirrors

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