Dr. John A. Kozub Profile

Dr. John A. Kozub

at Vanderbilt Univ

SPIE Involvement:

Author

Publications (13)

SPIE Journal Paper | 12 October 2015 Open Access

Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser

John Kozub, Jin-H. Shen, Karen Joos, Ratna Prasad, M. Shane Hutson

JBO, Vol. 20, Issue 10, 105004, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.105004

KEYWORDS: Cornea, Laser ablation, Etching, Prototyping, Alexandrite lasers, Laser tissue interaction, Pulsed laser operation, Mid-IR, Tissues, Laser damage threshold

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Proceedings Article | 3 March 2010 Paper

Experimental retinectomy with a 6.1 µm Q-switched Raman-shifted alexandrite laser

Karen Joos, Ratna Prasad, John Kozub, Borislav Ivanov, Anita Agarwal, Jin H. Shen

Proceedings Volume 7550, 75500X (2010) https://doi.org/10.1117/12.846890

KEYWORDS: Retina, Alexandrite lasers, Q switched lasers, Mid-IR, Laser tissue interaction, Free electron lasers, Laser systems engineering, Vitreous, Raman spectroscopy, Prototyping

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Proceedings Article | 18 April 2005 Paper

Corneal ablation using the pulse stretched free electron laser

Mark Mackanos, Karen Joos, John Kozub, E. Jansen

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.596603

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Cornea, Tissues, Optical fibers, Statistical analysis, Eye, Laser sources, Absorption

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The Mark-III Free Electron Laser (FEL), tuned to λ=6.45 μm has been demonstrated to provide for efficient ablation in ocular and neural tissues with minimal collateral damage. To date, the role of the FEL pulse structure on the mechanism of ablation has not been determined. In an effort to study the role of the FEL micropulse on the ablation of corneal tissue, the native pulse structure of the FEL, a 2.85 gigahertz repetition of picosecond pulses within a five microsecond macropulse envelope, was changed using a a pulse stretcher. This device changes the duration of the micropulse from 1 picosecond to 30-200 picoseconds in length, thus reducing the peak intensity of the micropulse by as much as 200x the original intensity, while the macropulse energy remains unchanged. Two basic metrics were studied: the ablation threshold on water and the ablation crater depth on gelatin. These metrics were employed at λ=6.45 and 6.1 μm for 1, 100, and 200 picoseconds in micropulse duration. The results showed a very slight difference between the 1, 100, and 200 picosecond micropulse duration, given a 200 fold decrease in peak energy for both the threshold and crater depth measurements. Brightfield imaging was also performed to probe the ablation dynamics and showed no difference between the 1 and 200 ps micropulses. The effect of changing the micropulse duration was studied on the ablation of canine cornea. Craters (500 micron diameter) were created with 25 pulses at three times the ablation threshold as determined for water on freshly enucleated corneas within 12 hours of removal. Three rows of seven craters were created on the center of each cornea. The native one picosecond micropulse and 200 picosecond stretched micropulse were compared at λ=6.1 and 6.45 μm. Histological data shows that less thermal damage is present at 6.1 μm compared with 6.45 μm; however, there is no significant difference between the native and stretched pulses with respect to thermal damage.

Proceedings Article | 15 April 2005 Paper

Analysis of soft tissue ablation using the pulse stretched free electron laser

Mark Mackanos, John Kozub, Darrel Ellis, E. Duco Jansen

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.596608

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Laser tissue interaction, Tissues, Skin, Pulsed laser operation, Laser sources, Statistical analysis, Ultraviolet radiation

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Proceedings Article | 1 July 2004 Paper

Effect of FEL micropulse duration on ablation characteristics at 6.45 um

Mark Mackanos, John Kozub, E. Jansen

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.535803

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Tissues, Skin, Laser tissue interaction, Optical coherence tomography, Statistical analysis, Pulsed laser operation, Error analysis

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Proceedings Article | 1 June 2004 Paper

Effect of micropulse duration on tissue ablation using a stretched free electron laser pulse train

John Kozub, Mark Mackanos, Marcus Mendenhall, E. Duco Jansen

Proceedings Volume 5340, (2004) https://doi.org/10.1117/12.535893

KEYWORDS: Free electron lasers, Laser ablation, Picosecond phenomena, Tissues, Laser tissue interaction, Absorption, Pulsed laser operation, Spectroscopy, Skin, Optical coherence tomography

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Proceedings Article | 4 June 2002 Paper

Time-resolved electron beam energy spectrum diagnostics for Vanderbilt FEL

Bibo Feng, John Kozub, William Gabella

Proceedings Volume 4632, (2002) https://doi.org/10.1117/12.469760

KEYWORDS: Electron beams, Free electron lasers, Spectroscopy, Diagnostics, Data acquisition, Photodiodes, LabVIEW, Aluminum, Surgery, Oscilloscopes

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Proceedings Article | 1 April 2002 Paper

Measurements of the spectral and temporal evolution of FEL macropulses

John Kozub, Bibo Feng, William Gabella

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461375

KEYWORDS: Free electron lasers, Electron beams, Spectroscopy, Sensors, Phase shifts, Resonators, Oscilloscopes, Spectral resolution, Diagnostics, Pulsed laser operation

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Proceedings Article | 1 April 2002 Paper

Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 um

Glenn Edwards, M. Shane Hutson, Susanne Hauger, John Kozub, Jin-Hui Shen, Charles Shieh, Katie Topadze, Karen Joos

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461379

KEYWORDS: Free electron lasers, Tissues, Proteins, Picosecond phenomena, Laser ablation, Cornea, Diffusion, Explosives, Collagen, Retina

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Proceedings Article | 1 April 2002 Paper

W.M. Keck-Vanderbilt Free-Electron Laser Center facilities

William Gabella, Bibo Feng, John Kozub, David Piston

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461374

KEYWORDS: Free electron lasers, Electron beams, Surgery, Infrared spectroscopy, Spectroscopy, Picosecond phenomena, Tunable lasers, Tissues, Imaging systems, Infrared radiation

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Proceedings Article | 1 April 2002 Paper

Mid-infrared FEL absorption spectra

John Kozub, Bibo Feng, William Gabella

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461376

KEYWORDS: Free electron lasers, Absorption, Absorbance, Spectroscopy, Laser damage threshold, Electron beams, Mid-IR, Electrons, Signal attenuation, Barium

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SPIE Journal Paper | 1 February 1993

Biomedical applications of free-electron lasers

Glenn Edwards, J. Johnson, John Kozub, Jerri Tribble, Katrina Wagner

OE, Vol. 32, Issue 02, (February 1993) https://doi.org/10.1117/12.10.1117/12.60753

KEYWORDS: Free electron lasers, Infrared radiation, Biopolymers, Spectroscopy, Biomedical optics, Absorption, Energy transfer, Laser applications, Visible radiation, FT-IR spectroscopy

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Proceedings Article | 7 August 1992 Paper

Applications of free-electron lasers to measurements of energy transfer in biopolymers and materials

Glenn Edwards, J. Johnson, John Kozub, Jerri Tribble, Katrina Wagner

Proceedings Volume 1646, (1992) https://doi.org/10.1117/12.137462

KEYWORDS: Free electron lasers, Biopolymers, Spectroscopy, Energy transfer, Infrared radiation, FT-IR spectroscopy, Visible radiation, Raman spectroscopy, Physics, Infrared detectors

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Showing 5 of 13 publications

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