Dr. Kate L. Bechtel Profile

Dr. Kate L. Bechtel

VP, Sensing Products at Rockley Photonics

SPIE Involvement:

Author | Career Panelist

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Company Website

Publications (6)

Proceedings Article | 21 February 2017 Presentation + Paper

Modeling of transdermal fluorescence measurements from first-in-human clinical trials for renal function determination using fluorescent tracer agent MB-102

Kimberly Shultz, Martin Debreczeny, Richard Dorshow, Jennifer Keating, Kate Bechtel

Proceedings Volume 10079, 100790I (2017) https://doi.org/10.1117/12.2251068

KEYWORDS: Monte Carlo methods, Kidney, Signal detection, Tissue optics, Fluorescence spectroscopy, Mathematical modeling, Instrument modeling, Diffusion, Skin, Blood, Optical properties, Scattering, Light

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SPIE Journal Paper | 17 February 2015 Open Access

Noninvasive glucose sensing by transcutaneous Raman spectroscopy

Wei-Chuan Shih, Kate Bechtel, Mihailo Rebec

JBO, Vol. 20, Issue 05, 051036, (February 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.051036

KEYWORDS: Glucose, Raman spectroscopy, Calibration, Ear, Blood, Error analysis, Statistical analysis, Plasma, Signal to noise ratio, Tissue optics

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Proceedings Article | 16 March 2011 Paper

X-ray dose reduction by adaptive source equalization and electronic region-of-interest control

Steve Burion, Anne Sandman, Kate Bechtel, Edward Solomon, Tobias Funk

Proceedings Volume 7961, 79612B (2011) https://doi.org/10.1117/12.877250

KEYWORDS: X-rays, Image quality, Collimators, X-ray imaging, X-ray detectors, Sensors, Computer simulations, Fluoroscopy, Lung, Software development

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Radiation dose is particularly a concern in pediatric cardiac fluoroscopy procedures, which account for 7% of all cardiac procedures performed. The Scanning-Beam Digital X-ray (SBDX) fluoroscopy system has already demonstrated reduced dose in adult patients owing to its high-DQE photon-counting detector, reduced detected scatter, and the elimination of the anti-scatter grid. Here we show that the unique flexible illumination platform of the SBDX system will enable further dose area product reduction, which we are currently developing for pediatric patients, but which will ultimately benefit all patients. The SBDX system has a small-area detector array and a large-area X-ray source with up to 9,000 individually-controlled X-ray focal spots. Each focal spot illuminates a small fraction of the full field of view. To acquire a frame, each focal spot is activated for a fixed number of 1-microsecond periods. Dose reduction is made possible by reducing the number of activations of some of the X-ray focal spots during each frame time. This can be done dynamically to reduce the exposure in areas of low patient attenuation, such as the lung field. This spatially-adaptive illumination also reduces the dynamic range in the full image, which is visually pleasing. Dose can also be reduced by the user selecting a region of interest (ROI) where full image quality is to be maintained. Outside the ROI, the number of activations of each X-ray focal spot is reduced and the image gain is correspondingly increased to maintain consistent image brightness. Dose reduction is dependent on the size of the ROI and the desired image quality outside the ROI. We have developed simulation software that is based on real data and can simulate the performance of the equalization and ROI filtration. This software represents a first step toward real-time implementation of these dose-reduction methods. Our simulations have shown that dose area product reductions of 40% are possible using equalization, and dose savings as high as 74% are possible with the ROI approach. The dose reduction achieved in clinical use will depend on patient anatomy.

SPIE Journal Paper | 1 March 2009 Open Access

Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy

Condon Lau, Obrad Scepanovic, Jelena Mirkovic, Sasha McGee, Chung-Chieh Yu, Stephen Fulghum, Michael Wallace, James Tunnell, Kate Bechtel, Michael Feld

JBO, Vol. 14, Issue 02, 024031, (March 2009) https://doi.org/10.1117/12.10.1117/1.3116708

KEYWORDS: Light scattering, Reflectivity, Tissue optics, Scattering, Spectroscopy, Diffuse reflectance spectroscopy, Tissues, Packaging, Model-based design, Absorption

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SPIE Journal Paper | 1 March 2008 Open Access

Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy

Zoya Volynskaya, Abigail Haka, Kate Bechtel, Maryann Fitzmaurice, Robert Shenk, Nancy Wang, Jonathan Nazemi, Ramachandra Dasari, Michael Feld

JBO, Vol. 13, Issue 02, 024012, (March 2008) https://doi.org/10.1117/12.10.1117/1.2909672

KEYWORDS: Diagnostics, Luminescence, Breast, Tissues, Breast cancer, Diffuse reflectance spectroscopy, Iterated function systems, Fluorescence spectroscopy, Algorithm development, Spectroscopy

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SPIE Journal Paper | 1 November 2007 Open Access

Determination of uncertainty in parameters extracted from single spectroscopic measurements

Obrad Scepanovic, Kate Bechtel, Abigail Haka, Wei-Chuan Shih, Tae-Woong Koo, Andrew Berger, Michael Feld

JBO, Vol. 12, Issue 06, 064012, (November 2007) https://doi.org/10.1117/12.10.1117/1.2815692

KEYWORDS: Raman spectroscopy, Statistical analysis, Diagnostics, Arteries, Tissues, Error analysis, Calibration, Spectroscopy, Interference (communication), Biological research

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