We propose a hybrid laser microfabrication approach for the manufacture of UV photochemical fused silica microchannel reactors using ultrafast laser-assisted etching combined with carbon dioxide laser irradiation. The manufactured glass microchannel reactors not only enable high transmission rates of multi-wavelength UV light irradiation but also allow micro-flow high-pressure and high-temperature intensification. As a proof-of-concept of this approach, one-step continuous-flow synthesis of vitamin D3 in the manufactured reactors is demonstrated.
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