Dr. Mladen Korbelik Profile

Dr. Mladen Korbelik

Scientist Emeritus at BC Cancer Agency Research Ctr

SPIE Involvement:

Conference Program Committee | Author

Publications (36)

Proceedings Article | 13 March 2024 Presentation

Photodynamic therapy as distinct type of immunogenic anti-tumor modality for use in clinical cancer immunotherapy

Mladen Korbelik

Proceedings Volume PC12843, PC1284304 (2024) https://doi.org/10.1117/12.3003611

KEYWORDS: Photodynamic therapy, Cancer, Modulation, Cell death

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Proceedings Article | 14 August 2019 Presentation

Cancer PDT vaccines: progress and prospects (Conference Presentation)

Mladen Korbelik

Proceedings Volume 11070, 110703N (2019) https://doi.org/10.1117/12.2528211

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Defense and security, In vitro testing, Cell death

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Proceedings Article | 9 March 2015 Paper

Activity of glycated chitosan and other adjuvants to PDT vaccines

Mladen Korbelik, Judit Banáth, Evaldas Čiplys, Zdzislaw Szulc, Alicja Bielawska, Wei Chen

Proceedings Volume 9324, 932407 (2015) https://doi.org/10.1117/12.2077276

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Oncology, Laser therapeutics, Proteins, Biomedical optics, Ultrasonography, Cervical cancer, Lung cancer

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SPIE Journal Paper | 23 January 2015 Open Access

Aggregation of nanoparticles in endosomes and lysosomes produces surface-enhanced Raman spectroscopy

Leanne Lucas, Xiaoke Chen, Aaron J. Smith, Mladen Korbelik, Haishan Zeng, Patrick W. Lee, Kevin Hewitt

JNP, Vol. 9, Issue 01, 093094, (January 2015) https://doi.org/10.1117/12.10.1117/1.JNP.9.093094

KEYWORDS: Surface enhanced Raman spectroscopy, Nanoparticles, Raman spectroscopy, Gold, Cancer, Proteins, Particles, Transmission electron microscopy, Receptors, Molecules

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Proceedings Article | 5 March 2010 Paper

Carbon nanotube assisted photothermal therapy of skin cancers: pilot proof-of-principle study in a murine model

Naiyan Huang, Hequn Wang, Jianhua Zhao, Harvey Lui, Mladen Korbelik, Haishan Zeng

Proceedings Volume 7548, 75480H (2010) https://doi.org/10.1117/12.848279

KEYWORDS: Tumors, Single walled carbon nanotubes, Raman spectroscopy, Carbon nanotubes, Tumor growth modeling, Laser irradiation, Nanomaterials, Skin cancer, Cancer, Tissue optics

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Proceedings Article | 11 February 2010 Paper

Tumor PDT-associated immune response: relevance of sphingolipids

Mladen Korbelik, Soroush Merchant, Duska Separovic

Proceedings Volume 7565, 756502 (2010) https://doi.org/10.1117/12.842760

KEYWORDS: Tumors, Photodynamic therapy, Stereolithography, Cancer, Cell death, Laser sintering, Oncology, Plasma, Molecules, Analog electronics

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Proceedings Article | 19 February 2009 Paper

In vivo confocal Raman spectroscopy for skin disease diagnosis and characterization: preliminary results from mouse tumor models

Hequn Wang, Naiyan Huang, Jianhua Zhao, Harvey Lui, Mladen Korbelik, Haishan Zeng

Proceedings Volume 7161, 716108 (2009) https://doi.org/10.1117/12.810953

KEYWORDS: Skin, Raman spectroscopy, Tumors, Confocal microscopy, In vivo imaging, Tissue optics, Skin cancer, Chemical analysis, Spectroscopy, Collagen

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Proceedings Article | 18 February 2009 Paper

Imaging EGFR distribution using surface-enhanced Raman spectroscopy

L. Lucas, X. K. Chen, A. Smith, M. Korbelik, H. Zeng, P. W. Lee, K. Hewitt

Proceedings Volume 7192, 719206 (2009) https://doi.org/10.1117/12.808337

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Nanoparticles, Gold, Cancer, Particles, Transmission electron microscopy, Image enhancement, Receptors, Spectroscopy

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Proceedings Article | 18 February 2008 Paper

Hormonal component of tumor photodynamic therapy response

Mladen Korbelik, Soroush Merchant

Proceedings Volume 6857, 685705 (2008) https://doi.org/10.1117/12.764023

KEYWORDS: Tumors, Photodynamic therapy, Proteins, Liver, Cancer, Receptors, Tissues, Control systems, Inflammation, Blood

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Proceedings Article | 13 February 2007 Paper

Advances in the understanding of host response associated with tumor PDT

Mladen Korbelik

Proceedings Volume 6438, 643802 (2007) https://doi.org/10.1117/12.698404

KEYWORDS: Tumors, Photodynamic therapy, Proteins, Cancer, In vitro testing, In vivo imaging, Oncology, Oxygen, Photosensitizer targeting, Lymphatic system

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Proceedings Article | 23 February 2006 Paper

Acute phase response induced following tumor treatment by photodynamic therapy: relevance for the therapy outcome

Mladen Korbelik, Soroush Merchant, Brandon Stott, Ivana Cecic, Peter Payne, Jinghai Sun

Proceedings Volume 6087, 60870C (2006) https://doi.org/10.1117/12.640302

KEYWORDS: Tumors, Photodynamic therapy, Tissues, Proteins, Inflammation, Liver, Plasma, Injuries, Molecules, Cancer

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Proceedings Article | 15 April 2005 Paper

Synergistic effects of laser and adjuvant therapies for cancer: progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy, and chemotherapy

Wei Chen, Kenneth Bartels, Mladen Korbelik, Hong Liu, Robert Nordquist

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.603986

KEYWORDS: Photodynamic therapy, Tumors, Therapeutics, Cancer, Oncology, Phototherapy, Photothermal interactions, Laser therapeutics, Lung, Tissue optics

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Proceedings Article | 15 April 2005 Paper

Complement activation approaches for use in conjunction with PDT for cancer treatment

Mladen Korbelik, Graeme Dougherty

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.589548

KEYWORDS: Photodynamic therapy, Tumors, Proteins, Tissues, Cancer, Oncology, Receptors, Molecules, Injuries, Solids

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Proceedings Article | 18 January 2005 Paper

Cancer treatment by photothermal, photochemical, and photobiological interactions

Wei Chen, Mladen Korbelik, Hong Liu, Robert Nordquist

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.568554

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Oncology, Photothermal interactions, Tissue optics, Photochemical interactions, Lung, Laser therapeutics, Laser tissue interaction

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Proceedings Article | 20 August 2004 Paper

Laser immunotherapy: a novel approach for metastatic tumors

Wei Chen, Mladen Korbelik, Kenneth Bartels, Hong Liu, Robert Nordquist

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578319

KEYWORDS: Tumors, Photodynamic therapy, Laser tissue interaction, Photothermal interactions, Dye lasers, Resistance, Molecular lasers, Laser therapeutics, Control systems, Laser development

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Proceedings Article | 1 July 2004 Paper

Enhancement of glycated chitosan in laser cancer treatment

Wei Chen, Sang Jeong, Mladen Korbelik, Kenneth Bartels, Steven Martin, Jinghai Sun, Hong Liu, Robert Nordquist

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.530577

KEYWORDS: Tumors, Photodynamic therapy, Melanoma, Cancer, Laser irradiation, Oncology, Lung, Laser therapeutics, Laser tissue interaction, Photothermal interactions

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Proceedings Article | 1 July 2004 Paper

Role of Toll-like receptors in photodynamic-therapy-elicited host response

Mladen Korbelik

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.529783

KEYWORDS: Tumors, Photodynamic therapy, Receptors, Proteins, Cancer, Molecules, System on a chip, Tissues, Plasma, Pathogens

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Proceedings Article | 8 December 2003 Paper

Dye-enhanced selective photothermal laser-tissue interaction and photodynamic therapy in combination with immunoadjuvant for cancer treatment

Wei Chen, Kenneth Bartels, Jinghai Sun, Hong Liu, Robert Nordquist, Mladen Korbelik

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546093

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Indocyanine green, Solids, Laser tissue interaction, Oncology, Control systems, Photochemical interactions, Laser irradiation

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Proceedings Article | 27 August 2003 Paper

Progress in the development of photodynamic-therapy-generated cancer vaccines

Mladen Korbelik, Jinghai Sun

Proceedings Volume 4961, (2003) https://doi.org/10.1117/12.473745

KEYWORDS: Tumors, Cancer, Photodynamic therapy, Lung cancer, Proteins, Melanoma, Receptors, Tumor growth modeling, Solids, In vitro testing

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Proceedings Article | 9 July 2001 Paper

Relevance of PDT-induced inflammatory response for the outcome of photodynamic therapy

Mladen Korbelik, Ivana Cecic, Jinghai Sun

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434715

KEYWORDS: Tumors, Photodynamic therapy, Injuries, Cancer, Tissues, Oncology, Defense and security, Proteins, Oxygen, Ischemia

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Proceedings Article | 9 April 2001 Paper

Role of inflammatory cytokines in the response of solid cancers to photodynamic therapy

Mladen Korbelik, Jinghai Sun, Ivana Cecic, Graeme Dougherty

Proceedings Volume 4248, (2001) https://doi.org/10.1117/12.424442

KEYWORDS: Photodynamic therapy, Tumors, Cancer, Solids, Tumor growth modeling, Blood, Tissues, Mouse models, Modulation, Proteins

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Proceedings Article | 13 June 2000 Paper

Immunotherapy regimens for combination with photodynamic therapy aimed at eradication of solid cancers

Mladen Korbelik

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388030

KEYWORDS: Photodynamic therapy, Tumors, Cancer, Solids, Oncology, Lymphatic system, Modulators, Proteins, Oxygen, Tissue optics

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Proceedings Article | 6 July 1999 Paper

Examples of adjuvant treatment enhancing the antitumor effect of photodynamic therapy

Mladen Korbelik, Ivana Cecic, Jinghai Sun, David Chaplin

Proceedings Volume 3592, (1999) https://doi.org/10.1117/12.351507

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Cell death, Tumor growth modeling, Oncology, Absorption, NOx, Tissues, Solids

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Proceedings Article | 14 June 1999 Paper

Antitumor immune reaction elicited by photodynamic therapy

Mladen Korbelik

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.349988

KEYWORDS: Tumors, Photodynamic therapy, Proteins, Cancer, Injuries, Molecules, Inflammation, Oncology, Oxygen, Solids

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Proceedings Article | 19 May 1998 Paper

Relevance of nitric oxide to the response of tumors to photodynamic therapy

Mladen Korbelik, Hiroshi Shibuya, Ivana Cecic

Proceedings Volume 3247, (1998) https://doi.org/10.1117/12.308136

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Blood circulation, NOx, Modulation, Injuries, Tissues, Oxygen, Molecules

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Proceedings Article | 13 May 1998 Paper

Cancer treatment by photodynamic therapy combined with NK-cell-line-based adoptive immunotherapy

Mladen Korbelik, Jinghai Sun

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308148

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Lymphatic system, Oncology, Molecules, Receptors, Proteins, In vitro testing, Solids

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Proceedings Article | 2 April 1996 Paper

Modulation of tumor response to photodynamic therapy in severe combined immunodeficient (SCID) mice by adoptively transferred lymphoid cells

Mladen Korbelik, Gorazd Krosl, Jana Krosl, Graeme Dougherty

Proceedings Volume 2675, (1996) https://doi.org/10.1117/12.237533

KEYWORDS: Tumors, Photodynamic therapy, Lymphatic system, Bone, Tissues, Spleen, Modulation, Tissue optics, Cancer, Oncology

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Proceedings Article | 1 May 1995 Paper

Distinctive role of activated tumor-associated macrophages in photosensitizer accumulation

Mladen Korbelik, Gorazd Krosl

Proceedings Volume 2392, (1995) https://doi.org/10.1117/12.208181

KEYWORDS: Tumors, Luminescence, Flow cytometry, Tissues, Monoclonal antibodies, Receptors, Spleen, Tumor growth modeling, Heart, Excel

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Proceedings Article | 1 March 1995 Paper

Potentiation of photodynamic therapy by granulocyte-macrophage colony stimulating factor immunotherapy

Gorazd Krosl, Mladen Korbelik, Jana Krosl, Graeme Dougherty

Proceedings Volume 2371, (1995) https://doi.org/10.1117/12.203373

KEYWORDS: Photodynamic therapy, Tumors

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Proceedings Article | 1 March 1995 Paper

Tumor-associated macrophages (not tumor cells) are the determinants of photosensitizer tumor localization

Mladen Korbelik, Gorazd Krosl

Proceedings Volume 2371, (1995) https://doi.org/10.1117/12.203372

KEYWORDS: Tumors, Solids, Flow cytometry, Tumor growth modeling, Lung, Receptors

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Proceedings Article | 1 March 1994 Paper

Distribution of photosensitizers between tumor cells and tumor infiltrating host cells

Mladen Korbelik, Gorazd Krosl

Proceedings Volume 2078, (1994) https://doi.org/10.1117/12.168679

KEYWORDS: Tumors, Luminescence, Flow cytometry, Blood vessels, Lymphatic system, Monoclonal antibodies, Ultraviolet radiation, Cancer, Photodynamic therapy, Aluminum

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Proceedings Article | 18 June 1993 Paper

Fluorescence imaging of premalignant and malignant tissues with and without photosensitizers

Stephen Lam, Calum MacAulay, Jean Le Riche, Jianan Qu, Gorazd Krosl, Haishan Zeng, Mladen Korbelik, Branko Palcic

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146306

KEYWORDS: Luminescence, Lung cancer, Tissues, Tumors, Cancer, Bronchoscopy, Helium cadmium lasers, Tumor growth modeling, Imaging devices, CCD cameras

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Proceedings Article | 18 June 1993 Paper

Electron microscopy study of tumor destruction by photodynamic therapy

Mladen Korbelik, Jasenka Matisic, Gorazd Krosl

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146323

KEYWORDS: Tumors, Photodynamic therapy, Electron microscopy, Bioalcohols, Capillaries, Tissues, Light, Tumor growth modeling, Cancer, Light sources

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Proceedings Article | 5 March 1993 Paper

Can PDT be potentiated by immunotherapy?

Mladen Korbelik, Gorazd Krosl, David Chaplin

Proceedings Volume 1616, (1993) https://doi.org/10.1117/12.136977

KEYWORDS: Tumors, Photodynamic therapy, Lung, Tissues, In vitro testing, In vivo imaging, Photosensitizer targeting, Tumor growth modeling, Tissue optics, Luminescence

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Proceedings Article | 1 June 1992 Paper

Host cell infiltration into PDT-treated tumor

Mladen Korbelik, Gorazd Krosl, Graeme Dougherty, David Chaplin

Proceedings Volume 1645, (1992) https://doi.org/10.1117/12.60935

KEYWORDS: Tumors, Photodynamic therapy, Cancer, Analytical research, Tumor growth modeling, Tissues, Monoclonal antibodies, Solids, Magnesium, Microelectromechanical systems

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Proceedings Article | 1 June 1991 Paper

Microlocalization of Photofrin in neoplastic lesions

Mladen Korbelik, Gorazd Krosl, Stephen Lam, David Chaplin, Branko Palcic

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44056

KEYWORDS: Tumors, Luminescence, Lung, Blood vessels, Fluorescence spectroscopy, Photodynamic therapy, Tissues, Tumor growth modeling, Imaging systems, Animal model studies

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Showing 5 of 36 publications

Conference Committee Involvement (21)

Biophotonics and Immune Responses XX

25 January 2025 | San Francisco, California, United States

Biophotonics and Immune Responses XIX

28 January 2024 | San Francisco, California, United States

Biophotonics and Immune Responses XVIII

30 January 2023 | San Francisco, California, United States

Biophotonics and Immune Responses XVII

24 January 2022 | San Francisco, California, United States

Biophotonics and Immune Responses XVI

6 March 2021 | Online Only, California, United States

Biophotonics and Immune Responses XV

3 February 2020 | San Francisco, California, United States

Biophotonics and Immune Responses XIV

4 February 2019 | San Francisco, California, United States

Biophotonics and Immune Responses XIII

29 January 2018 | San Francisco, California, United States

Biophotonics and Immune Responses XII

30 January 2017 | San Francisco, California, United States

Biophotonics and Immune Responses XI

15 February 2016 | San Francisco, California, United States

Biophotonics and Immune Responses X

9 February 2015 | San Francisco, California, United States

Biophotonics and Immune Responses IX

3 February 2014 | San Francisco, California, United States

Biophotonics and Immune Responses VIII

4 February 2013 | San Francisco, California, United States

Biophotonics and Immune Responses VII

23 January 2012 | San Francisco, California, United States

Biophotonics and Immune Responses VI

24 January 2011 | San Francisco, California, United States

Biophotonics and Immune Responses V

25 January 2010 | San Francisco, California, United States

Therapeutic Laser Applications and Laser-Tissue Interactions

17 June 2009 | Munich, Germany

Biophotonics and Immune Responses IV

25 January 2009 | San Jose, California, United States

Biophotonics and Immune Responses III

21 January 2008 | San Jose, California, United States

Biophotonics and Immune Responses II

22 January 2007 | San Jose, California, United States

Biophotonics and Immune Responses

23 January 2006 | San Jose, California, United States

Showing 5 of 21 Conference Committees

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