The treatment of macular diseases requires frequent monitoring by optical coherence tomography (OCT). Home monitoring would reduce the burden of frequent clinical visits and increase therapy adherence. In a pilot study with 47 patients having different macular diseases we tested a proprietary self-examination low-cost full-field OCT (SELFF-OCT). For comparison, scans with a standard clinical spectral domain OCT were taken. Data was graded by a reading center. Patients were able to successfully acquire images that were clinically gradable for 85% of the included eyes. The sensitivity and specificity for an anti-VEGF treatment decision based on the SELFF-OCT was 0.94 and 0.95, respectively.
Off-axis full-field OCT is intended to enable cost-effective imaging of the retina for home diagnosis.
Different to common FD-OCT systems, the lateral field of view is acquired in a single shot and the
different axial layers are acquired sequentially. During acquisition, motion of the eye results in
motion artifacts and misaligned layers. We present a method to track the axial and lateral position of
the retina by analyzing the angle and divergence of the backscattered light with a lateral precision of
3.6 µm and an axial precision of 29 µm. This information can be used to correct motion induced
errors.
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