The results of the study of the possibilities of the method of differential Mueller-matrix mapping of the completely polarized polycrystalline component of the optically thick layers of the myocardium dead due to coronary heart disease (CHD) and acute coronary insufficiency (ACI) are presented.
This report contains theoretical algorithm for the differential representation of a phaseinhomogeneous biological object as a set of consecutively located optically anisotropic layers; theoretical algorithms for the decomposition of the Mueller-matrix of the diffuse biological layer in the basis of differential matrices of the 1st and 2nd orders; analytical relations for determining the magnitude of the set of elements of differential matrices of the 1st and 2nd orders;information and characteristics of optical schemes of experimental devices.
The materials of the experimental determination of the set of maps and histograms of the distribution of the magnitude of the fluctuations of linear (DFLB) birefringence for differential diagnosis and the formation of hemorrhages of traumatic origin, cerebral infarction ischemic and hemorrhagic genesis by diffuse tomography of the polycrystalline structure of histological sections of the brain.
For a high-precision objective histological determination of the prescription of damage to internal organs over a long period of time, a systematic approach was used based on digital azimuthally invariant polarizing, Mueller-matrix and tomographic methods for studying temporary changes in the molecular and polycrystalline structure of brain, liver and kidney samples in the post-mortal period. It was revealed that a linear change in the magnitude of statistical moments of the 1st - 4th orders characterizing the distribution of data of digital azimuthally invariant polarizing, Mueller-matrix and tomographic methods is interconnected with the duration of damage to internal organs. On this basis, a new algorithm for digital histological determination of the prescription of the occurrence of damage is proposed. To determine the extent of damage, the method of azimuthally invariant polarization microscopy with different magnification of the image of histological sections of tissues of internal organs was used, which provided diagnostic relationships between changes in the magnitude of statistical moments of the 1st to 4th orders, which characterize the azimuth and elliptic polarization maps of digital microscopic images and time intervals of damage duration.
This paper contains data of experimental studies of the coordinate structure of phase shift distributions between orthogonal polarization states of laser images of blood samples of preoperative (group A), postoperative (group B), postoperative with a course of chemotherapy (group C) cancer patients registered for different spectral ("red"λ1=0,632μm and "blue"λ2=0,414μm) ranges. Two-dimensional distributions of phase shifts between orthogonal polarization states of the “red” and “blue” laser images of cancer patients in groups A, B, and C are presented and analyzed. According to this results, phase criteria for the differentiation of laser images of unoperated, operated and operated patients with chemotherapy were established. Samples of the topological structure of phase shift distributions between orthogonal polarization states of laser images of blood samples of three groups of cancer patients were studied, and the patterns of their coordinate and spatial-frequency construction were established. According to this, the self-similarity of phase distributions (at different levels of their stationary values) of laser radiation in polarization images of blood samples of patients of A, B and C groups was studied.
This paper contains structural and logical scheme of the research; theoretical information about the set of azimuthally invariant Mueller-matrix elements and their combinations; The work is aimed at the development of a set of techniques that form a new method of azimuthally invariant differential polarimetry of partially-depolarizing optically anisotropic biological layers. This method is based on the determination and diagnostic use of a set of physical relationships between the distributions of azimuthally invariant polarization parameters characterizing the optical anisotropy of partially depolarizing layers of biological tissues, and the distributions of the parameters of linear and circular birefringence of such objects.
Experimental studies within the statistical approach of the coordinate structure of the distributions of the intensity of own fluorescence of polycrystalline blood plasma films of patients of the following groups: control group of donors - group 1; patients with non-alcoholic fatty liver disease - group 2; patients with chronic hepatitis - group 3: The average values and ranges of variation of statistical moments of the 1st - 4th orders determined within the representative samples, which characterize the coordinate distributions of the intensity values of autofluorescent microscopic images of samples of polycrystalline blood plasma films within groups 1, 2, 3. The analysis of the operating characteristics of the power of the method of laser polarization mapping of two-dimensional distributions of the intensity values of its own fluorescence of microscopic images based on the determination of the sensitivity values, specificity and accuracy of the diagnostic test.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.