Mr. Paul R. Bloemen Profile

Paul R. Bloemen

Technical Engineer at Amsterdam UMC

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Author

Publications (8)

Proceedings Article | 13 March 2024 Presentation

All-reflective tethered capsule endoscope for multimodal esophageal imaging

Xavier Attendu, Paul Bloemen, Niels Kind, Daniel de Bruin, Dirk Faber, Caroline Boudoux, Ton van Leeuwen

Proceedings Volume PC12820, PC128200D (2024) https://doi.org/10.1117/12.3003072

KEYWORDS: Biological imaging, Optical coherence tomography, Multimodal imaging, Endoscopes, Multiplexing, Mirrors, Mechanical engineering, Imaging spectroscopy, Image stabilization, Image analysis

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Proceedings Article | 11 August 2023 Paper

Ex-vivo OCT on human bladder tissue after radical cystectomy with a newly designed MEMS based forward looking OCT probe

M. Remmelink, Y. Rip, P. Bloemen, R. van Elzen, J. Oddens, J. Nieuwenhuijzen, J. van der Voorn, T. van Leeuwen, T. de Reijke, D. de Bruin

Proceedings Volume 12627, 126271Q (2023) https://doi.org/10.1117/12.2670125

KEYWORDS: Optical coherence tomography, Microelectromechanical systems, Bladder, Tissues, Bladder cancer, Resection, In vivo imaging, Cancer, Single mode fibers, Resistors

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Proceedings Article | 17 March 2023 Presentation

All-reflective tethered capsule endoscope for multimodal esophageal imaging

Xavier Attendu, Paul Bloemen, Niels Kind, Dirk Faber, Daniel de Bruin, Caroline Boudoux, Ton van Leeuwen

Proceedings Volume PC12356, PC123560H (2023) https://doi.org/10.1117/12.2650005

KEYWORDS: Multimodal imaging, Endoscopes, Optical coherence tomography, Reflectivity, Mirrors, Optical alignment, Mechanical engineering, Luminescence, Laser marking, Imaging spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Combined optical coherence tomography and broadband single fiber reflectance spectroscopy

Xavier Attendu, Paul Bloemen, Niels Kind, Daniel de Bruin, Dirk Faber, Caroline Boudoux, Ton van Leeuwen

Proceedings Volume 11634, 1163403 (2021) https://doi.org/10.1117/12.2578129

KEYWORDS: Optical coherence tomography, Reflectance spectroscopy, Scanners, Head, Imaging systems, Chromatic aberrations, Standards development, Reflectivity, Optical properties, Multimode fibers

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Proceedings Article | 19 July 2019 Paper

Improved forward scatter detection of a flow cytometer for detection of extracellular vesicles

P. Bloemen, L. de Rond, E. van der Pol, T. van Leeuwen, F. A. Coumans

Proceedings Volume 11073, 1107313 (2019) https://doi.org/10.1117/12.2527919

KEYWORDS: Sensors, Signal to noise ratio, Laser scattering, Scattering, Refractive index, Photomultipliers, Optical design, Mie scattering, Photodiodes, Zemax

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Proceedings Article | 14 March 2018 Presentation

3D Fluorescence Imaging cryomicrotome system for multispectral structural, functional and molecular imaging of whole organs (Conference Presentation)

Paul Bloemen, Iwan Dobbe, Coen Dijkman, Niels Kind, Maurice Aalders, Ton van Leeuwen, Maria Siebes

Proceedings Volume 10487, 104870B (2018) https://doi.org/10.1117/12.2290142

KEYWORDS: Imaging systems, 3D image processing, Luminescence, Stereoscopy, Tissues, Image resolution, Bandpass filters, Molecular imaging, Multispectral imaging, Optical imaging

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Proceedings Article | 19 April 2017 Presentation

Modeling short-range delivery and collection of light: incorporating the influence of the phase function (Conference Presentation)

Anouk Post, Roosje Ruis, Paul Bloemen, Ton van Leeuwen, Henricus J. C. Sterenborg, Dirk Faber

Proceedings Volume 10062, 100620Z (2017) https://doi.org/10.1117/12.2251446

KEYWORDS: Spectroscopy, Tissue optics, Optical coherence tomography, Optical properties, Scattering, Tissues, In vivo imaging, Optical testing, Backscatter, Light scattering

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Proceedings Article | 27 April 2016 Presentation

Quantification of numerical aperture-dependence of the OCT attenuation coefficient (Conference Presentation)

Liliana Peinado, Paul Bloemen, Mitra Almasian, Ton van Leeuwen, Dirk Faber

Proceedings Volume 9698, 96980Q (2016) https://doi.org/10.1117/12.2210966

KEYWORDS: Optical coherence tomography, Signal attenuation, Bladder cancer, Scattering, Visualization, Tissue optics, Point spread functions, Diagnostics, Cancer, Tumors

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Despite the improvements in early cancer diagnosis, adequate diagnostic tools for early staging of bladder cancer tumors are lacking [1]. MEMS-probes based on optical coherence tomography (OCT) provide cross-sectional imaging with a high-spatial resolution at a high-imaging speed, improving visualization of cancerous tissue [2-3]. Additionally, studies show that the measurement of localized attenuation coefficient allows discrimination between healthy and cancerous tissue [4]. We have designed a new miniaturized MEMS-probe based on OCT that will optimize early diagnosis by improving functional visualization of suspicious lesions in bladder. During the optical design phase of the probe, we have studied the effect of the numerical aperture (NA) on the OCT signal attenuation. For this study, we have employed an InnerVision Santec OCT system with several numerical apertures (25mm, 40mm, 60mm, 100mm, 150mm and 200mm using achromatic lenses). The change in attenuation coefficient was studied using 15 dilutions of intralipid ranging between 6*10-5 volume% and 20 volume%. We obtained the attenuation coefficient from the OCT images at several fixed positions of the focuses using established OCT models (e.g. single scattering with known confocal point spread function (PSF) [5] and multiple scattering using the Extended Huygens Fresnel model [6]). As a result, a non-linear increase of the scattering coefficient as a function of intralipid concentration (due to dependent scattering) was obtained for all numerical apertures. For all intralipid samples, the measured attenuation coefficient decreased with a decrease in NA. Our results suggest a non-negligible influence of the NA on the measured attenuation coefficient. [1] Khochikar MV. Rationale for an early detection program for bladder cancer. Indian J Urol 2011 Apr-Jun; 27(2): 218–225. [2] Sun J and Xie H. Review Article MEMS-Based Endoscopic Optical Coherence Tomography. IJO 2011, Article ID 825629, 12 pages. doi:10.1155/2011/825629. [3] Jung W and Boppart S. Optical coherence tomography for rapid tissue screening and directed histological sectioning. Anal Cell Pathol (Amst). 2012; 35(3): 129–143. [4] R. Wessels et al. Optical coherence tomography in vulvar intraepithelial neoplasia. J Biomed Opt 2012 Nov; 17(11): 116022. [5] Faber D, van der Meer F, Aalders M, van Leeuwen T. Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. OPT EXPRESS 2004; 12 (19): 4353-43. [6] Thrane L, Yura HT, and Andersen PE. Analysis of optical coherence tomography systems based on the extended Huygens–Fresnel principle. JOSA 2000; 17(3): 484-490.

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