Dr. Peter J. Littrup Profile

Dr. Peter J. Littrup

at Karmanos Cancer Institute

SPIE Involvement:

Author

Publications (35)

Proceedings Article | 14 March 2018 Presentation

Volumetric breast density comparisons between waveform UST sound speed imaging and mammography (Conference Presentation)

Mark Sak, Neb Duric, Peter Littrup

Proceedings Volume 10580, 1058010 (2018) https://doi.org/10.1117/12.2296649

KEYWORDS: Breast, Tissues, Mammography, Ultrasound tomography, Breast imaging, Ionizing radiation, Image resolution, Reconstruction algorithms

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Proceedings Article | 14 March 2018 Presentation

Ultrasound tomography for breast cancer screening (Conference Presentation)

Neb Duric, Peter Littrup, Mark Sak, Yash Sandhu, Cuiping Li

Proceedings Volume 10580, 1058011 (2018) https://doi.org/10.1117/12.2296657

KEYWORDS: Ultrasound tomography, Breast cancer, Breast imaging, Breast, Imaging systems, Tissues, Magnetic resonance imaging, Mammography, Ultrasonography, Gold

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Proceedings Article | 14 March 2018 Presentation

Breast tissue characterization with sound speed and tissue stiffness imaging (Conference Presentation)

Cuiping Li, Gursharan Sandhu, Michael Boone, Neb Duric, Peter Littrup, Kenneth Bergman

Proceedings Volume 10580, 105800Y (2018) https://doi.org/10.1117/12.2294929

KEYWORDS: Tissues, Breast, Breast cancer, Ultrasonography, Mammography, Cancer, Ultrasound tomography, Signal attenuation, In vivo imaging

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Proceedings Article | 13 March 2017 Presentation + Paper

Ultrasound tomography imaging with waveform sound speed: parenchymal changes in women undergoing tamoxifen therapy

Mark Sak, Neb Duric, Peter Littrup, Mark Sherman, Gretchen Gierach

Proceedings Volume 10139, 101390W (2017) https://doi.org/10.1117/12.2254472

KEYWORDS: Breast, Ultrasound tomography, Tissues, Image quality, Ultrasonography, Image resolution, Image visualization, Mammography, Breast cancer, Clocks, Image segmentation

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Proceedings Article | 13 March 2017 Paper

A comparison of automated versus manual segmentation of breast UST transmission images to measure breast volume and sound speed

Mark Sak, Neb Duric, Peter Littrup, Katelyn Westerberg

Proceedings Volume 10139, 101391H (2017) https://doi.org/10.1117/12.2254482

KEYWORDS: Image segmentation, Breast, Ultrasound tomography, Ultrasonography, Tissues, Image analysis, Chest, Breast imaging, Nipple, Transducers

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Proceedings Article | 1 April 2016 Paper

Using ultrasound tomography to identify the distributions of density throughout the breast

Mark Sak, Neb Duric, Peter Littrup, Mark Sherman, Gretchen Gierach

Proceedings Volume 9790, 979019 (2016) https://doi.org/10.1117/12.2217611

KEYWORDS: Breast, Ultrasound tomography, Mammography, Ultrasonography, Breast cancer, Tomography, Visualization, Image analysis, Medicine, Brain-machine interfaces, Cancer, Tissue optics

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Proceedings Article | 17 March 2015 Paper

Comparison of breast density measurements made using ultrasound tomography and mammography

Mark Sak, Neb Duric, Peter Littrup, Lisa Bey-Knight, Mark Krycia, Mark Sherman, Norman Boyd, Gretchen Gierach

Proceedings Volume 9419, 94190R (2015) https://doi.org/10.1117/12.2082802

KEYWORDS: Breast, Tissues, Mammography, Brain-machine interfaces, Ultrasound tomography, Cancer, Breast cancer, Tomography, Image segmentation, Image compression

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Proceedings Article | 17 March 2015 Paper

Whole breast tissue characterization with ultrasound tomography

Neb Duric, Peter Littrup, Cuiping Li, Olivier Roy, Steve Schmidt, John Seamans, Andrea Wallen, Lisa Bey-Knight

Proceedings Volume 9419, 94190G (2015) https://doi.org/10.1117/12.2083203

KEYWORDS: Breast, Cancer, Tissues, Ultrasonography, In vivo imaging, Mammography, Elastography, Signal attenuation, Ultrasound tomography, Imaging systems

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Proceedings Article | 20 March 2014 Paper

Comparison of sound speed measurements on two different ultrasound tomography devices

Mark Sak, Neb Duric, Peter Littrup, Lisa Bey-Knight, Mark Sherman, Gretchen Gierach, Antonina Malyarenko

Proceedings Volume 9040, 90400S (2014) https://doi.org/10.1117/12.2043113

KEYWORDS: Breast, Tissues, Cancer, Ultrasound tomography, Ultrasonography, Breast cancer, 3D image processing, Computing systems, Tomography, Data acquisition

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Ultrasound tomography (UST) employs sound waves to produce three-dimensional images of breast tissue and precisely measures the attenuation of sound speed secondary to breast tissue composition. High breast density is a strong breast cancer risk factor and sound speed is directly proportional to breast density. UST provides a quantitative measure of breast density based on three-dimensional imaging without compression, thereby overcoming the shortcomings of many other imaging modalities. The quantitative nature of the UST breast density measures are tied to an external standard, so sound speed measurement in breast tissue should be independent of specific hardware. The work presented here compares breast sound speed measurement obtained with two different UST devices. The Computerized Ultrasound Risk Evaluation (CURE) system located at the Karmanos Cancer Institute in Detroit, Michigan was recently replaced with the SoftVue ultrasound tomographic device. Ongoing clinical trials have used images generated from both sets of hardware, so maintaining consistency in sound speed measurements is important. During an overlap period when both systems were in the same exam room, a total of 12 patients had one or both of their breasts imaged on both systems on the same day. There were 22 sound speed scans analyzed from each system and the average breast sound speeds were compared. Images were either reconstructed using saved raw data (for both CURE and SoftVue) or were created during the image acquisition (saved in DICOM format for SoftVue scans only). The sound speed measurements from each system were strongly and positively correlated with each other. The average difference in sound speed between the two sets of data was on the order of 1-2 m/s and this result was not statistically significant. The only sets of images that showed a statistical difference were the DICOM images created during the SoftVue scan compared to the SoftVue images reconstructed from the raw data. However, the discrepancy between the sound speed values could be easily handled by uniformly increasing the DICOM sound speed by approximately 0.5 m/s. These results suggest that there is no fundamental difference in sound speed measurement for the two systems and support combining data generated with these instruments in future studies.

Proceedings Article | 20 March 2014 Paper

Breast imaging with SoftVue: initial clinical evaluation

Neb Duric, Peter Littrup, Cuiping Li, Olivier Roy, Steven Schmidt, Xiaoyang Cheng, John Seamans, Andrea Wallen, Lisa Bey-Knight

Proceedings Volume 9040, 90400V (2014) https://doi.org/10.1117/12.2043768

KEYWORDS: Breast, Imaging systems, Magnetic resonance imaging, Cancer, Tissues, Image fusion, Image processing, Breast imaging, Signal attenuation, Ultrasonography

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Proceedings Article | 29 March 2013 Open Access

Breast imaging with the SoftVue imaging system: first results

Neb Duric, Peter Littrup, Steven Schmidt, Cuiping Li, Olivier Roy, Lisa Bey-Knight, Roman Janer, Dave Kunz, Xiaoyang Chen, Jeffrey Goll, Andrea Wallen, Fouzaan Zafar, Veerendra Allada, Erik West, Ivana Jovanovic, Kuo Li, William Greenway

Proceedings Volume 8675, 86750K (2013) https://doi.org/10.1117/12.2002513

KEYWORDS: Breast, Prototyping, Imaging systems, Cancer, Tissues, Ultrasonography, Mammography, Breast cancer, Breast imaging, Signal attenuation

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Proceedings Article | 29 March 2013 Paper

Breast density measurements using ultrasound tomography for patients undergoing tamoxifen treatment

Mark Sak, Neb Duric, Peter Littrup, Cuiping Li, Lisa Bey-Knight, Mark Sherman, Norman Boyd, Gretchen Gierach

Proceedings Volume 8675, 86751E (2013) https://doi.org/10.1117/12.2007146

KEYWORDS: Breast, Breast cancer, Ultrasound tomography, Mammography, Tissues, Cancer, Receptors, Brain-machine interfaces, Tomography, Oncology

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Proceedings Article | 25 February 2012 Paper

Breast tissue composition and breast density measurements from ultrasound tomography

Mark Sak, Neb Duric, Norman Boyd, Peter Littrup, Erik West, Cuiping Li

Proceedings Volume 8320, 83200Q (2012) https://doi.org/10.1117/12.912407

KEYWORDS: Breast, Mammography, Tissues, Ultrasound tomography, Image segmentation, Breast cancer, Ultrasonography, Cancer, Tomography, Image analysis

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Proceedings Article | 25 February 2012 Paper

Breast ultrasound tomography: bridging the gap to clinical practice

Neb Duric, Peter Littrup, Cuiping Li, Olivier Roy, Steven Schmidt, Roman Janer, Xiaoyang Cheng, Jeffrey Goll, Olsi Rama, Lisa Bey-Knight, William Greenway

Proceedings Volume 8320, 83200O (2012) https://doi.org/10.1117/12.910988

KEYWORDS: Breast, Prototyping, Scanners, Breast cancer, Magnetic resonance imaging, Transducers, Cancer, Ultrasound tomography, Mammography, Data acquisition

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Conventional sonography, which performs well in dense breast tissue and is comfortable and radiation-free, is not practical for screening because of its operator dependence and the time needed to scan the whole breast. While magnetic resonance imaging (MRI) can significantly improve on these limitations, it is also not practical because it has long been prohibitively expensive for routine use. There is therefore a need for an alternative breast imaging method that obviates the constraints of these standard imaging modalities. The lack of such an alternative is a barrier to dramatically impacting mortality (about 45,000 women in the US per year) and morbidity from breast cancer because, currently, there is a trade-off between the cost effectiveness of mammography and sonography on the one hand and the imaging accuracy of MRI on the other. This paper presents a progress report on our long term goal to eliminate this trade-off and thereby improve breast cancer survival rates and decrease unnecessary biopsies through the introduction of safe, cost-effective, operatorindependent sonography that can rival MRI in accuracy. The objective of the study described in this paper was to design and build an improved ultrasound tomography (UST) scanner in support of our goals. To that end, we report on a design that builds on our current research prototype. The design of the new scanner is based on a comparison of the capabilities of our existing prototype and the performance needed for clinical efficacy. The performance gap was quantified by using clinical studies to establish the baseline performance of the research prototype, and using known MRI capabilities to establish the required performance. Simulation software was used to determine the basic operating characteristics of an improved scanner that would provide the necessary performance. Design elements focused on transducer geometry, which in turn drove the data acquisition system and the image reconstruction engine specifications. The feasibility of UST established by our earlier work and that of other groups, forms the rationale for developing a UST system that has the potential to become a practical, low-cost device for breast cancer screening and diagnosis.

Proceedings Article | 26 March 2011 Paper

Breast imaging with ultrasound tomography: update on a comparative study with MR

Bryan Ranger, Peter Littrup, Neb Duric, Cuiping Li, Steven Schmidt, Olsi Rama, Lisa Bey-Knight

Proceedings Volume 7968, 79680M (2011) https://doi.org/10.1117/12.878922

KEYWORDS: Breast, Magnetic resonance imaging, Tissues, Signal attenuation, Image fusion, Visualization, Ultrasound tomography, Cancer, Image processing, Prototyping

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Proceedings Article | 26 March 2011 Paper

Relationship between breast sound speed and mammographic percent density

Mark Sak, Nebojsa Duric, Norman Boyd, Peter Littrup, Lukasz Myc, Muhammad Faiz, Cuiping Li, Lisa Bey-Knight

Proceedings Volume 7968, 79680N (2011) https://doi.org/10.1117/12.878934

KEYWORDS: Breast, Mammography, Breast cancer, Tissues, Ultrasound tomography, Digital mammography, Prototyping, Acoustics, Ionizing radiation, Cancer

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Proceedings Article | 25 March 2011 Paper

In-vivo imaging of breast cancer with ultrasound tomography: probing the tumor environment

Nebojsa Duric, Peter Littrup, Erik West, Bryan Ranger, Cuiping Li, Steven Schmidt

Proceedings Volume 7968, 796812 (2011) https://doi.org/10.1117/12.878939

KEYWORDS: Tumors, Tissues, Signal attenuation, Cancer, Breast, Breast cancer, Ultrasonography, Image fusion, Ultrasound tomography, Prototyping

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Proceedings Article | 12 March 2010 Paper

Breast imaging with ultrasound tomography: a comparative study with MRI

Bryan Ranger, Peter Littrup, Neb Duric, Cuiping Li, Steven Schmidt, Jessica Lupinacci, Lukasz Myc, Amy Szczepanski, Olsi Rama, Lisa Bey-Knight

Proceedings Volume 7629, 762906 (2010) https://doi.org/10.1117/12.845650

KEYWORDS: Magnetic resonance imaging, Ultrasound tomography, Tissues, Prototyping, Breast, Tumors, Visualization, Breast imaging, Magnetism, Mammography

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Proceedings Article | 12 March 2010 Paper

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Jessica Lupinacci, Neb Duric, Peter Littrup, Ding Wang, Cuiping Li, Steven Schmidt, Bryan Ranger, Erik West, Amy Szczepanski, Olsi Rama, Lisa Bey-Knight, Lukasz Myc

Proceedings Volume 7629, 76291C (2010) https://doi.org/10.1117/12.845647

KEYWORDS: Tumors, Breast, Breast cancer, Prototyping, Ultrasound tomography, Surgery, Magnetic resonance imaging, Cancer, Image fusion, Signal attenuation

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Proceedings Article | 12 March 2010 Paper

Volumetric breast density evaluation by ultrasound tomography and magnetic resonance imaging: a preliminary comparative study

Lukasz Myc, Neb Duric, Peter Littrup, Cuiping Li, Bryan Ranger, Jessica Lupinacci, Steven Schmidt, Olsi Rama, Lisa Bey-Knight

Proceedings Volume 7629, 76290N (2010) https://doi.org/10.1117/12.845648

KEYWORDS: Breast, Magnetic resonance imaging, Breast cancer, Tissues, Ultrasound tomography, Mammography, Chest, Cancer, Ultrasonography, Analytical research

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Proceedings Article | 12 March 2010 Paper

In-vivo imaging results with ultrasound tomography: report on an ongoing study at the Karmanos Cancer Institute

Nebojsa Duric, Peter Littrup, Priti Chandiwala-Mody, Cuiping Li, Steven Schmidt, Lukasz Myc, Olsi Rama, Lisa Bey-Knight, Jessica Lupinacci, Bryan Ranger, Amy Szczepanski, Erik West

Proceedings Volume 7629, 76290M (2010) https://doi.org/10.1117/12.845646

KEYWORDS: Breast, Image fusion, Signal attenuation, Prototyping, Cancer, Ultrasonography, Tissues, Magnetic resonance imaging, Acoustics, Ultrasound tomography

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Proceedings Article | 21 March 2009 Paper

Breast imaging with acoustic tomography: a comparative study with MRI

Bryan Ranger, Peter Littrup, Neb Duric, Cuiping Li, Jessica Lupinacci, Lukasz Myc, Olsi Rama, Lisa Bey-Knight

Proceedings Volume 7265, 726510 (2009) https://doi.org/10.1117/12.813350

KEYWORDS: Magnetic resonance imaging, Breast, Tissues, Acoustics, Tomography, Mammography, Prototyping, Signal attenuation, Image fusion, Cancer

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Proceedings Article | 21 March 2009 Paper

Detection and characterization of breast masses with ultrasound tomography: clinical results

Neb Duric, Peter Littrup, Cuiping Li, Olsi Rama, Lisa Bey-Knight, Steven Schmidt, Jessica Lupinacci

Proceedings Volume 7265, 72651G (2009) https://doi.org/10.1117/12.812994

KEYWORDS: Breast, Signal attenuation, Ultrasonography, Image fusion, Cancer, Tissues, Prototyping, Acoustics, Mammography, Magnetic resonance imaging

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Proceedings Article | 14 March 2009 Paper

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Jessica Lupinacci, Neb Duric, Peter Littrup, Ding Wang, Cuiping Li, Steven Schmidt, Olsi Rama, Lisa Bey-Knight, Lukasz Myc

Proceedings Volume 7265, 726517 (2009) https://doi.org/10.1117/12.812975

KEYWORDS: Tumors, Breast, Magnetic resonance imaging, Prototyping, Breast cancer, Image fusion, Ultrasound tomography, Acoustics, Signal attenuation, Tissues

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Proceedings Article | 13 March 2009 Paper

Temperature monitoring during tissue freezing using ultrasound speed measurements

I. Jovanovic, A. Hormati, P. Littrup, N. Duric, O. Rama, M. Vetterli

Proceedings Volume 7265, 72650Q (2009) https://doi.org/10.1117/12.813682

KEYWORDS: Tissues, Reconstruction algorithms, Temperature metrology, Breast, Ultrasonography, Therapeutics, Wavelets, Tomography, Ultrasound tomography, Signal attenuation

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Proceedings Article | 19 March 2008 Paper

Multi-modal breast imaging with ultrasound tomography

Neb Duric, Cuiping Li, Peter Littrup, Carri Glide-Hurst, Lianjie Huang, Jessica Lupinacci, Steven Schmidt, Olsi Rama, Lisa Bey-Knight, Yang Xu

Proceedings Volume 6920, 69200O (2008) https://doi.org/10.1117/12.772203

KEYWORDS: Breast, Image fusion, Signal attenuation, Ultrasound tomography, Cancer, Ultrasonography, Tissues, Transducers, Breast imaging, Mammography

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Proceedings Article | 13 March 2008 Paper

A novel ultrasonic method for measuring breast density and breast cancer risk

Carri Glide-Hurst, Neb Duric, Peter Littrup

Proceedings Volume 6920, 69200Q (2008) https://doi.org/10.1117/12.772365

KEYWORDS: Breast, Mammography, Tissues, Breast cancer, Acoustics, Ultrasonography, Image segmentation, Ultrasound tomography, Ultrasonics, Visualization

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Proceedings Article | 19 March 2007 Paper

Sound-speed and attenuation imaging of breast tissue using waveform tomography of transmission ultrasound data

R. Gerhard Pratt, Lianjie Huang, Neb Duric, Peter Littrup

Proceedings Volume 6510, 65104S (2007) https://doi.org/10.1117/12.708789

KEYWORDS: Tomography, Breast, Transducers, Signal attenuation, Ultrasonography, Data modeling, In vivo imaging, Tumors, Diffraction, Skin

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Proceedings Article | 16 March 2006 Paper

Breast imaging with time-reversed ultrasound

Lianjie Huang, Nebojsa Duric, Peter Littrup

Proceedings Volume 6147, 61470I (2006) https://doi.org/10.1117/12.659845

KEYWORDS: Breast, Ultrasonics, Data modeling, Ultrasonography, Transducers, Image resolution, Wave propagation, Breast imaging, Mirrors, Tissues

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Proceedings Article | 23 May 2003 Paper

Ultrasonic breast imaging using a wave-equation migration method

Lianjie Huang, Nebojsa Duric, Peter Littrup

Proceedings Volume 5035, (2003) https://doi.org/10.1117/12.479915

KEYWORDS: Ultrasonics, Breast, Breast imaging, Ultrasonography, X-rays, Cancer, Tissues, X-ray imaging, Receivers, X-ray computed tomography

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Proceedings Article | 23 May 2003 Paper

Ultrasound tomography of breast tissue

Nebojsa Duric, Peter Littrup, Earle Holsapple, Alex Babkin, Robert Duncan, Arkady Kalinin, Roman Pevzner, Michael Tokarev

Proceedings Volume 5035, (2003) https://doi.org/10.1117/12.479909

KEYWORDS: Tissues, Breast, Ultrasonography, Acoustics, Tomography, Signal attenuation, Scanners, Scattering, Cancer, Prototyping

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Proceedings Article | 11 April 2002 Paper

Using data fusion to characterize breast tissue

Nebojsa Duric, Peter Littrup, Richard Leach, Steve Azevedo, James Candy, Thomas Moore, David Chambers, Jeffrey Mast, Earle Holsapple

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462167

KEYWORDS: Tissues, Breast, X-rays, Ultrasonography, Reflectivity, X-ray imaging, Absorption, Data fusion, X-ray computed tomography, Image fusion

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Proceedings Article | 11 April 2002 Paper

Comparison of ultrasound tomography methods in circular geometry

Richard Leach, Steve Azevedo, James Berryman, Hugo Bertete-Aguirre, David Chambers, Jeffrey Mast, Peter Littrup, Nebojsa Duric, Steven Johnson, Frank Wuebbeling

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462173

KEYWORDS: Tissues, Reconstruction algorithms, Ultrasonography, Breast, Tomography, CT reconstruction, Image resolution, Transducers, Algorithm development, Image quality

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Proceedings Article | 11 April 2002 Paper

Characterizing tissue with acoustic parameters derived from ultrasound data

Peter Littrup, Nebojsa Duric, Richard Leach, Steve Azevedo, James Candy, Thomas Moore, David Chambers, Jeffrey Mast, Earle Holsapple

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462172

KEYWORDS: Tissues, Breast, Ultrasonography, Signal attenuation, Acoustics, Reflectivity, Scattering, Reconstruction algorithms, Scanners, Algorithm development

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Proceedings Article | 11 April 2002 Paper

Ultrasound imaging using diffraction tomography in a cylindrical geometry

David Chambers, Peter Littrup

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462181

KEYWORDS: Tissues, Breast, Acoustics, Ultrasonography, Signal attenuation, Tomography, Diffraction, Imaging systems, Image resolution, Scattering

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Showing 5 of 35 publications

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