Considering the considerable use of sedative drugs like methadone as a frequent substitution for additive drugs, we have investigated their effect on the cell activity via highly-resolved optical sensing method. Using plasmonic ellipsometry technique, a conspicuous shift in plasmonic resonance wavelength of the cultured chips was observed due to methadone presence during the cell culture of mesenchymal stem cells. This highly-sensitive platform can open new avenues towards the detection of drug effect on human cells and in large scale, on human organs.
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