Prof. Shudong Jiang Profile

Prof. Shudong Jiang

Professor at Thayer School of Engineering at Dartmouth

SPIE Involvement:

Conference Program Committee | Editorial Board Member: Journal of Biomedical Optics | Author

Publications (74)

SPIE Journal Paper | 18 November 2024 Open Access

Combined dual-channel fluorescence depth sensing of indocyanine green and protoporphyrin IX kinetics in subcutaneous murine tumors

Madhusudan Kulkarni, Matthew Reed, Xu Cao, Héctor García, Marien Ochoa, Shudong Jiang, Tayyaba Hasan, Marvin Doyley, Brian Pogue

JBO, Vol. 30, Issue S1, S13709, (November 2024) https://doi.org/10.1117/12.10.1117/1.JBO.30.S1.S13709

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SignificanceFluorescence sensing within tissue is an effective tool for tissue characterization; however, the modality and geometry of the image acquisition can alter the observed signal.AimWe introduce a novel optical fiber-based system capable of measuring two fluorescent contrast agents through 2 cm of tissue with simple passive electronic switching between the excitation light, simultaneously acquiring fluorescence and excitation data. The goal was to quantify indocyanine green (ICG) and protoporphyrin IX (PpIX) within tissue, and the sampling method was compared with wide-field surface imaging to contrast the value of deep sensing versus surface imaging.ApproachThis was achieved by choosing filters for specific wavelengths that were mutually exclusive between ICG and PpIX and coupling these filters to two separate detectors, which allows for direct swapping of the excitation and emission channels by switching the on-time of each excitation laser between 780- and 633-nm wavelengths.ResultsThis system was compared with two non-contact surface imaging systems for both ICG and PpIX, which revealed that the fluorescence depth sensing system was superior in its ability to resolve kinetics differences in deeper tissues that would normally be dominated by strong signals from skin and other surface tissues. Specifically, the system was tested using pancreatic adenocarcinoma tumors injected into murine models, which were imaged at several time points throughout tumor growth to its ∼6-mm diameter. This demonstrated the system’s capability to track longitudinal changes in ICG and PpIX kinetics that result from tumor growth and development, with larger tumors showing sluggish uptake and clearance of ICG, which was not observable with surface imaging. Similarly, PpIX was quantified, which showed slower kinetics over different time points, and was further compared with the wide-filed imager. These results were further validated through depth measurements in tissue phantoms and model-based interpretation.ConclusionThis fluorescence depth sensing system can be used to sample the interior blood flow characteristics by ICG sensing of tissue as deep as 20 mm into the tissue with sensitivity to kinetics that are superior to surface imaging and may be combined with other imaging modalities such as ultrasound to provide guided deep fluorescence measurements.

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SPIE Journal Paper | 6 September 2024 Open Access

Patient-specific arterial input function for accurate perfusion assessment in intraoperative fluorescence imaging

Yue Tang, Shudong Jiang, Joseph Sottosanti, Thomas Usherwood, Xu Cao, Logan Bateman, Lillian Fisher, Eric Henderson, Ida Leah Gitajn, Jonathan Thomas Elliott

JBO, Vol. 29, Issue S3, S33306, (September 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S3.S33306

KEYWORDS: Tissues, Bone, Biological imaging, Targeting Task Performance metric, Fluorescence imaging, Skin, Modeling, Accuracy assessment, Blood, Perfusion imaging

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Proceedings Article | 13 March 2024 Presentation + Paper

Onward to better surgery - the critical need for improved ex vivo testing and training methods

Eric Henderson, Ryan Halter, Keith Paulsen, Brian Pogue, Jonathan Elliott, Ethan LaRochelle, Alberto Ruiz, Shudong Jiang, Samuel Streeter, Kimberley Samkoe, Summer Gibbs

Proceedings Volume 12825, 1282506 (2024) https://doi.org/10.1117/12.3010121

KEYWORDS: Surgery, Tissues, Animals, Animal model studies, Tumor growth modeling, Perfusion imaging, Optical properties, In vivo imaging, Diseases and disorders, Cancer

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Proceedings Article | 13 March 2024 Poster + Paper

Prototype dual-channel fluorescence/transmission optical tomography system for quantification of capillary permeability and porphyrin production

Madhusudan Kulkarni, Matthew Reed, Shudong Jiang, Xu Cao, Tayyaba Hasan, Marvin Doyley, Brian Pogue

Proceedings Volume 12825, 128250F (2024) https://doi.org/10.1117/12.3021036

KEYWORDS: Tissues, Fluorescence, Optical tomography, Prototyping, Optical transmission, Linear filtering, Data acquisition, Capillaries, Fluorescence intensity, Animals

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Fluorescence optical tomography systems have been invented to directly measure several deep tissue features. While the highly scattered nature of the signal degrades spatial resolution, this scattering process also dramatically increases the optical path length and thereby amplifies the signal sensitivity to features such as capillaries and cells, suppressing the dominance of major blood vessels. The potential for high optical contrast with centimeter-level penetration into tissue motivates sampling (i) capillary leakage with a temporal sampling of indocyanine green (ICG); (ii) mitochondrial activity with protoporphyrin IX (PpIX) intensity, and (iii) oxygen metabolism sensing with delayed fluorescence of PpIX. In this work, the single-channel prototype of an optical fiber-based tomography system was developed for these purposes. The system was comprised of two sources of laser diodes, at 633 nm and 780 nm wavelengths, two avalanche photodiode detectors, a DAQ I/O card as a control and data collection unit, and fiber cables with filter blocks, all run via LabView control. The detection fiber channels included a notch filter in each arm, at 633nm and 750nm wavelengths that act as a band stop filter for these wavelengths. Fiber cables deliver and receive light from the tissue, enabling a closed-loop passive switching system. This design has a dual-purpose channel fiber system that makes it possible to just electronically switch between sequential measurement of indocyanine green (ICG) excitation (785 nm) and protoporphyrin IX (PpIX) excitation (635 nm) without any optical component movements, while transmission of the excitation signal is implicitly measured at the opposite detector. The fluorescence-to-transmission ratio data eliminates issues of fiber coupling or tissue transmission variations. The system was validated for linearity of response in relevant biological concentration ranges for each fluorophore. Also, in vivo animal studies were carried out on a mouse to see the reliability of the system at capturing the temporal ICG kinetics. This single design of dual-channel detection is a prototype for what will be a multi-fiber tomography system that can measure the intrinsic properties of tissue coupled with ultrasound imaging.

SPIE Journal Paper | 3 January 2024 Open Access

Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Yue Tang, Ida Leah Gitajn, Xu Cao, Xinyue Han, Jonathan Elliott, Logan Bateman, Bethany Malskis, Lillian Fisher, Jessica Sin, Eric Henderson, Shudong Jiang

JBO, Vol. 29, Issue 01, 016001, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.016001

KEYWORDS: Bone, Fluorescence imaging, Biological imaging, Fluorescence intensity, Surgery, Imaging systems, Tissues, Fluorescence, Histograms, Perfusion imaging

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SPIE Journal Paper | 29 June 2023 Open Access

Monitoring optoporated process on mammalian cells by real-time measurement of membrane resealing time

Xiaofan Du, Lei Fu, Zhuqu Wang, Zhenxi Zhang, Shudong Jiang, Jing Wang, Cuiping Yao

JBO, Vol. 28, Issue 06, 065006, (June 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.6.065006

KEYWORDS: Laser irradiation, Fluorescence, Monte Carlo methods, Fluorescence intensity, Diffusion, Molecules, Data modeling, Gold nanoparticles, Time metrology, Pulsed laser operation

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SPIE Journal Paper | 20 April 2023 Open Access

Stable tissue-mimicking phantoms for longitudinal multimodality imaging studies that incorporate optical, CT, and MRI contrast

Mengyang Zhao, Mingwei Zhou, Xu Cao, Jinchao Feng, Brian W. Pogue, Keith D. Paulsen, Shudong Jiang

JBO, Vol. 28, Issue 04, 046006, (April 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.4.046006

KEYWORDS: Pigments, Optical properties, Magnetic resonance imaging, Multimodal imaging, Tissues, X-ray computed tomography, Computed tomography, Breast, Soft tissue optics, Near infrared

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Proceedings Article | 15 March 2023 Presentation + Paper

Risk prediction on orthopaedic trauma patients for fracture-associated infection using dynamic contrast enhanced-fluorescence imaging

Xinyue Han, Logan Bateman, Paul Werth, Shudong Jiang, I. Leah Gitajn, Jonathan Thomas Elliott

Proceedings Volume 12361, 123610A (2023) https://doi.org/10.1117/12.2650773

KEYWORDS: Surgery, Tissues, Bone, Biological imaging, Machine learning, Feature extraction, Information science, Fluorescence, Cross validation, Visualization

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Proceedings Article | 15 March 2023 Presentation + Paper

Fluorescence-guided and molecularly guided debridement: identifying devitalized and infected tissue in orthopaedic trauma

Jonathan Thomas Elliott, Eric Henderson, Samuel Streeter, Valentin Demidov, Xinyue Han, Yue Tang, J. Scott Sottosanti, Logan Bateman, Petr Brůža, Shudong Jiang, I. Leah Gitajn

Proceedings Volume 12361, 1236108 (2023) https://doi.org/10.1117/12.2661243

KEYWORDS: Tissues, Bone, Surgery, Injuries, Imaging systems, Fluorescence, Biofilms, Fluorescence imaging, Fluorescence intensity, Blood circulation

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Proceedings Article | 15 March 2023 Presentation + Paper

Automated motion artifact correction for dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Yue Tang, I. Leah Gitajn, Xu Cao, Xinyue Han, Jonathan Elliott, Xiaohan Yu, Logan Bateman, Bethany Malskis, Lillian Fisher, Jessica Sin, Eric Henderson, Brian Pogue, Shudong Jiang

Proceedings Volume 12361, 1236104 (2023) https://doi.org/10.1117/12.2650028

KEYWORDS: Bone, Surgery, Fluorescence imaging, Biological imaging, Perfusion imaging, Targeting Task Performance metric, Indocyanine green, Data acquisition, Orthopedic imaging, Bone imaging

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Proceedings Article | 15 March 2023 Presentation + Paper

Proceduralist criteria for evaluating interface utility of novel imaging modalities in early phase clinical trials: evaluating the need for standardized criteria

Eric Henderson, Jonathan Elliott, Shudong Jiang, I. Leah Gitajn, John Lee, Summer Gibbs, Michael Bouvet, Anita Mahadevan-Jansen, Michael Daly, Samuel Streeter, Keith Paulsen, Brian Pogue, Kimberley Samkoe, Sunil Singhal

Proceedings Volume 12361, 123610F (2023) https://doi.org/10.1117/12.2650756

KEYWORDS: Surgery, Tissues, Target recognition, Standards development, Visualization, Medical imaging, Imaging technologies, Clinical trials, Interfaces, Fluorophores

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Proceedings Article | 6 March 2023 Presentation + Paper

MRI-guided near-infrared spectroscopic tomographic system for breast cancer imaging: phantom and normal-subject studies

Mengyang Zhao, Xu Cao, Mingwei Zhou, Jinchao Feng, Luxi Xia, Brian Pogue, Keith Paulsen, Shudong Jiang

Proceedings Volume 12371, 1237104 (2023) https://doi.org/10.1117/12.2647571

KEYWORDS: Magnetic resonance imaging, Imaging systems, Interfaces, Signal detection, Data acquisition, Breast cancer, Tomography, Imaging spectroscopy, Multimodal imaging, Near infrared spectroscopy

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Proceedings Article | 4 March 2022 Presentation + Paper

Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery

Yue Tang, Jessica Sin, I. Leah Gitajn, Xu Cao, Xinyue Han, Jonathan Elliott, Xiaohan Yu, Melanie Christian, Logan Bateman, Theresa Chockbengboun, Eric Henderson, Brian Pogue, Shudong Jiang

Proceedings Volume 11943, 119430C (2022) https://doi.org/10.1117/12.2608382

KEYWORDS: Magnetic resonance imaging, Bone, Surgery, Software development, Data modeling, Indocyanine green, Orthopedic imaging, Bone imaging

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Proceedings Article | 2 March 2022 Poster + Paper

MRI-guided near-infrared spectroscopic tomography (MRg-NIRST): system development for wearable, simultaneous NIRS and MRI imaging

Mengyang Zhao, Xu Cao, Mingwei Zhou, Jinchao Feng, Luxi Xia, Brian Pogue, Keith Paulsen, Shudong Jiang

Proceedings Volume 11952, 119520E (2022) https://doi.org/10.1117/12.2607983

KEYWORDS: Breast cancer, Multimodal imaging, Tomography, Magnetic resonance imaging, Optical fibers, Data acquisition, Imaging systems, Interfaces, Near infrared spectroscopy

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Proceedings Article | 7 December 2021 Paper

Intraoperative assessment of patient bone viability using texture analysis of dynamic contrast-enhanced fluorescence imaging

Xinyue Han, Valentin Demidov, Shudong Jiang, Ida Leah Gitajn, Jonathan Elliott

Proceedings Volume 11919, 119190A (2021) https://doi.org/10.1117/12.2614457

KEYWORDS: Luminescence, Bone, Tissues, Surgery, Binary data, Image analysis, Image quality, Image classification, Feature extraction, Principal component analysis

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Proceedings Article | 5 March 2021 Paper

ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study

Shudong Jiang, Jonathan Elliott, Jin Xing, Xu Cao, Xiaohan Yu, Xinyue Han, Rebecca Dabrowski, Melanie Christian, Eric Henderson, Brian Pogue, I. Leah Gitajn

Proceedings Volume 11625, 116250W (2021) https://doi.org/10.1117/12.2578976

KEYWORDS: Bone, Luminescence, Tissues, Blood circulation, Surgery, Machine learning, Indocyanine green, Contamination

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Proceedings Article | 5 March 2021 Poster + Paper

MRI-guide near infrared spectroscopic tomographic imaging system with wearable optical breast interface for breast imaging

Shudong Jiang, Xu Cao, Mingwei Zhou, Jinchao Feng, Brian Pogue, Keith Paulsen

Proceedings Volume 11639, 116391J (2021) https://doi.org/10.1117/12.2579087

KEYWORDS: Breast, Magnetic resonance imaging, Tomography, Spectroscopy, Near infrared spectroscopy, Near infrared, Interfaces, Imaging spectroscopy, Light, Imaging systems

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Proceedings Article | 5 March 2021 Presentation + Paper

MRI guided wearable near infrared spectral tomography: simulation study

Jinchao Feng, Chengpu Wei, Shudong Jiang, Mingwei Zhou, Xu Cao, Brian Pogue, Keith Paulsen

Proceedings Volume 11639, 116390D (2021) https://doi.org/10.1117/12.2578356

KEYWORDS: Magnetic resonance imaging, Breast, Tomography, Near infrared, Sensors, Tumors, Sensing systems, Nipple, Near infrared spectroscopy, Light

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SPIE Journal Paper | 24 November 2020 Open Access

Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO₂ during radiotherapy

Xu Cao, Jason Gunn, Srinivasa Rao Allu, Petr Bruza, Shudong Jiang, Sergei Vinogradov, Brian Pogue

JBO, Vol. 25, Issue 11, 112704, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.112704

KEYWORDS: Oxygen, Tumors, Sensors, Tissues, Radiotherapy, Phosphorescence, Luminescence, Toxicity, Positron emission tomography, Image sensors

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Significance: The necessity to use exogenous probes for optical oxygen measurements in radiotherapy poses challenges for clinical applications. Options for implantable probe biotechnology need to be improved to alleviate toxicity concerns in human use and facilitate translation to clinical trial use. Aim: To develop an implantable oxygen sensor containing a phosphorescent oxygen probe such that the overall administered dose of the probe would be below the Federal Drug Administration (FDA)-prescribed microdose level, and the sensor would provide local high-intensity signal for longitudinal measurements of tissue pO2. Approach: PtG4, an oxygen quenched dendritic molecule, was mixed into an agarose matrix at 100 μM concentration, allowing for local injection into tumors at the total dose of 10 nmol per animal, forming a gel at the site of injection. Cherenkov-excited luminescence imaging (CELI) was used to acquire the phosphorescence and provide intratumoral pO2. Results: Although PtG4 does not form covalent bonds with agarose and gradually leaches out into the surrounding tissue, its retention time within the gel was sufficiently long to demonstrate the capability to measure intratumoral pO2 with the implantable gel sensors. The sensor’s performance was first evaluated in vitro in tissue simulation phantoms, and then the sensor was used to measure changes in oxygen in MDA-MB-231 tumors during hypofractionated radiotherapy. Conclusions: Our study demonstrates that implantable oxygen sensors in combination with CELI present a promising approach for quantifying oxygen changes during the course of radiation therapy and thus for evaluating the tumor response to radiation. By improving the design of the gel–probe composition in order to prevent leaching of the probe into the tissue, biosensors can be created that should allow longitudinal oxygen measurements in tumors by means of CELI while using FDA-compliant microdose levels of the probe and thus lowering toxicity concerns.

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SPIE Journal Paper | 31 August 2020 Open Access

Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery

Ida Gitajn, Gerard Slobogean, Eric Henderson, Arvind von Keudell, Mitchel Harris, John Scolaro, Nathan O'Hara, Jonathan Elliott, Brian Pogue, Shudong Jiang

JBO, Vol. 25, Issue 08, 080601, (August 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.8.080601

KEYWORDS: Tissues, Bone, Tissue optics, Surgery, Optical imaging, Injuries, Luminescence, Soft tissue optics, Near infrared, Spatial resolution

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Significance: Extremity injury represents the leading cause of trauma hospitalizations among adults under the age of 65 years, and long-term impairments are often substantial. Restoring function depends, in large part, on bone and soft tissue healing. Thus, decisions around treatment strategy are based on assessment of the healing potential of injured bone and/or soft tissue. However, at the present, this assessment is based on subjective clinical clues and/or cadaveric studies without any objective measure. Optical imaging is an ideal method to solve several of these issues. Aim: The aim is to highlight the current challenges in assessing bone and tissue perfusion/viability and the potentially high impact applications for optical imaging in orthopaedic surgery. Approach: The prospective will review the current challenges faced by the orthopaedic surgeon and briefly discuss optical imaging tools that have been published. With this in mind, it will suggest key research areas that could be evolved to help make surgical assessments more objective and quantitative. Results: Orthopaedic surgical procedures should benefit from incorporation of methods to measure functional blood perfusion or tissue metabolism. The types of measurements though can vary in the depth of tissue sampled, with some being quite superficial and others sensing several millimeters into the tissue. Most of these intrasurgical imaging tools represent an ideal way to improve surgical treatment of orthopaedic injuries due to their inherent point-of-care use and their compatibility with real-time management. Conclusion: While there are several optical measurements to directly measure bone function, the choice of tools can determine also the signal strength and depth of sampling. For orthopaedic surgery, real-time data regarding bone and tissue perfusion should lead to more effective patient-specific management of common orthopaedic conditions, requiring deeper penetrance commonly seen with indocyanine green imaging. This will lower morbidity and result in decreased variability associated with how these conditions are managed.

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SPIE Journal Paper | 9 June 2020 Open Access

Intraoperative fluorescence perfusion assessment should be corrected by a measured subject-specific arterial input function

Jonathan Elliott, Rocco Addante, Gerard Slobogean, Shudong Jiang, Eric Henderson, Brian Pogue, Ida Leah Gitajn

JBO, Vol. 25, Issue 06, 066002, (June 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.066002

KEYWORDS: Luminescence, Tissues, Targeting Task Performance metric, Skin, Bone, Brain, Error analysis, Angiography, Surgery, Densitometry

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Proceedings Article | 19 February 2020 Presentation + Paper

Endosteal and periosteal blood flow quantified with dynamic contrast-enhanced fluorescence to guide open orthopaedic surgery

Shudong Jiang, Jonathan Elliott, Jason Gunn, Cao Xu, Alberto Ruiz, Brian Pogue, Eric Henderson, I. Leah Gitajn

Proceedings Volume 11222, 112220F (2020) https://doi.org/10.1117/12.2546173

KEYWORDS: Bone, Luminescence, Blood, Tissues, Blood circulation, Surgery, Imaging systems, Indocyanine green, Video, Injuries

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Proceedings Article | 7 March 2019 Presentation + Paper

Tomographic Cherenkov-excited luminescence scanned imaging based on back-projection reconstruction demonstrates 0.3mm spatial resolution for molecular reporter through 2-3cm of tissue

Mengyu Jia, Xu Cao, Jason Gunn, Petr Bruza, Shudong Jiang, Brian Pogue

Proceedings Volume 10862, 108621A (2019) https://doi.org/10.1117/12.2513231

KEYWORDS: Luminescence, X-rays, Tomography, Signal to noise ratio, Tissues, Radiotherapy, Photons, Image restoration, Spatial resolution, Computed tomography

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Cherenkov-excited luminescence scanned imaging (CELSI) is achieved with External Beam Radiotherapy, to map out molecular luminescence intensity or lifetime in tissue. In order to realize a deeper imaging depth with a reasonable spatial resolution, we optimized the original scanning gesture to do in a similar way to computed tomography (CT) and the image reconstruction was instead used a customized Maximum-likelihood expectation maximization (ML-EM) for CELSI. In tomographic CELSI (TCELSI), tomographic images are generated by irradiating the subject using a sequence of programmed X-ray beams at a fixed projection angle, while sensitive measurement is to take a sum for all image pixels from an intensified charge-coupled device. By restricting the X-ray excitation to a single, narrow beam of radiation, the origin of the optical photons can be inferred regardless of where these photons were detected, and how many times they scattered in tissue. Measurement geometry was designed for clinical expectation: CT scanning was achieved by a clinical linear accelerator (LINAC), where X-ray beam sequence and multiple projections were realized with multi leaf collimator (MLC) and gantry movement, respectively. Furthermore, in most modern External Beam Radiotherapy, MLC movement is synchronized with gantry angle to release a uniform radiation, and some of treatment plans, e.g., Intensity Modulated Radiation Therapy (IMRT), have a potential to match the scanning way mentioned. By including Cherenkov imaging results, medium surface profile can be additionally acquired, which can be used as boundary reference to do depth correction and co-register with molecular images. Resolution phantom studies showed that a 0.3 mm diameter capillary tube containing 0.01 nM luminescent nanospheres could be recognized at a depth of 21 mm into tissue-like media. Small animal imaging with a 1 mm diameter cylindrical target demonstrated that fast 3D data acquisition was achieved by a multi-pinhole collimator to image local luminescence 20mm deep.

SPIE Journal Paper | 22 November 2018 Open Access

Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation

Xu Cao, Shudong Jiang, Mengyu Jeremy Jia, Jason Gunn, Tianshun Miao, Scott Davis, Petr Bruza, Brian Pogue

JBO, Vol. 24, Issue 05, 051405, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.5.051405

KEYWORDS: Short wave infrared radiation, Luminescence, Cameras, In vivo imaging, Infrared imaging, Infrared radiation, Electron beams, Tissues, Radiotherapy, Absorption

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SPIE Journal Paper | 19 October 2018 Open Access

Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment

Jeffrey M. Cochran, David R. Busch, Anaïs Leproux, Zheng Zhang, Thomas D. O’Sullivan, Albert E. Cerussi, Philip M. Carpenter, Rita S. Mehta, Darren Roblyer, Wei Yang, Keith D. Paulsen, Brian Pogue, Shudong Jiang, Peter A. Kaufman, So Hyun Chung, Mitchell Schnall, Bradley S. Snyder, Nola Hylton, Stefan A. Carp, Steven J. Isakoff, David Mankoff, Bruce J. Tromberg, Arjun G. Yodh

JBO, Vol. 24, Issue 02, 021202, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.021202

KEYWORDS: Tumors, Tissues, Oxygen, Breast, Tissue optics, Data modeling, Breast cancer, Tumor growth modeling, Radiology, Magnetic resonance imaging

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SPIE Journal Paper | 20 March 2018 Open Access

Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom

Syed Rakin Ahmed, Mengyu Jia, Petr Bruza, Sergei Vinogradov, Shudong Jiang, David Gladstone, Lesley Jarvis, Brian Pogue

JBO, Vol. 23, Issue 03, 030504, (March 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.3.030504

KEYWORDS: Luminescence, Tissue optics, Signal to noise ratio, Tissues, 3D image processing, Computed tomography, Phosphorescence, Lymphatic system, Skin, Signal detection

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SPIE Journal Paper | 17 August 2017 Open Access

Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial

Anaïs Leproux, Thomas O’Sullivan, Albert Cerussi, Amanda Durkin, Brian Hill, Nola Hylton, Arjun Yodh, Stefan Carp, David Boas, Shudong Jiang, Keith Paulsen, Brian Pogue, Darren Roblyer, Wei Yang, Bruce Tromberg

JBO, Vol. 22, Issue 12, 121604, (August 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121604

KEYWORDS: Absorption, Scattering, Calibration, Diffuse optical imaging, Optical imaging, Tissue optics, Reflectivity, Optical properties, Spectroscopes, Imaging spectroscopy

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Proceedings Article | 18 February 2017 Paper

Breast cancer detection using Ktrans MRI imaging to guide near infrared spectroscopy tomography

Jinchao Feng, Shudong Jiang, Junqing Xu, Yan Zhao, Jiang Gui, Brian Pogue, Keith Paulsen

Proceedings Volume 10059, 100590O (2017) https://doi.org/10.1117/12.2250649

KEYWORDS: Magnetic resonance imaging, Breast cancer, Image segmentation, Tomography, Near infrared, Near infrared spectroscopy, Diffuse optical tomography, Mammography, Magnetism, Data acquisition, Tumors, Breast, Image restoration, Tissues, Tissue optics, Reconstruction algorithms

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Proceedings Article | 17 February 2017 Paper

A portable 12-wavelength parallel near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer during neoadjuvant chemotherapy

Yan Zhao, William Burger, Mingwei Zhou, Brian Pogue, Keith Paulsen, Shudong Jiang

Proceedings Volume 10059, 100590R (2017) https://doi.org/10.1117/12.2252431

KEYWORDS: Continuous wave operation, Breast, Tomography, Imaging systems, Breast cancer, Tissues, Tissue optics, Spectroscopes, Diagnostics, Biomedical optics, Surgery, Sensors, Data acquisition, Light, Oncology, Tumors

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SPIE Journal Paper | 23 September 2016 Open Access

Multiobjective guided priors improve the accuracy of near-infrared spectral tomography for breast imaging

Jinchao Feng, Shudong Jiang, Junqing Xu, Yan Zhao, Brian Pogue, Keith Paulsen

JBO, Vol. 21, Issue 09, 090506, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.090506

KEYWORDS: Magnetic resonance imaging, Image restoration, Tumors, Image segmentation, Breast, Tomography, Reconstruction algorithms, Breast imaging, Image enhancement, 3D image reconstruction

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Proceedings Article | 29 February 2016 Paper

Monitoring longitudinal changes in irradiated head and neck cancer xenografts using diffuse reflectance spectroscopy

Karthik Vishwanath, Shudong Jiang, Jason Gunn, Kayla Marra, Jacqueline Andreozzi, Brian Pogue

Proceedings Volume 9689, 96891W (2016) https://doi.org/10.1117/12.2213192

KEYWORDS: Head, Neck, Cancer, Diffuse reflectance spectroscopy, Radiotherapy, Tissues, Tumors, Chromium, Electron beams, X-rays

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SPIE Journal Paper | 22 May 2015 Open Access

Optimization of image reconstruction for magnetic resonance imaging–guided near-infrared diffuse optical spectroscopy in breast

Yan Zhao, Michael Mastanduno, Shudong Jiang, Fadi El-Ghussein, Jiang Gui, Brian Pogue, Keith Paulsen

JBO, Vol. 20, Issue 05, 056009, (May 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.056009

KEYWORDS: Image restoration, Magnetic resonance imaging, Breast, Tissue optics, Scattering, Diagnostics, Reconstruction algorithms, Optimization (mathematics), Tumors, Data acquisition

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Proceedings Article | 5 March 2015 Paper

A portable and compact near-infrared spectral tomography system for predicting breast tumor response to neoadjuvant chemotherapy

Yan Zhao, Fadi El-Ghussein, Ziqi Zhang, Brian Pogue, Keith Paulsen, Shudong Jiang

Proceedings Volume 9319, 93190B (2015) https://doi.org/10.1117/12.2079210

KEYWORDS: Sensors, Breast, Calibration, Phase measurement, Data acquisition, Modulation, Semiconductor lasers, Near infrared spectroscopy, Continuous wave operation

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Proceedings Article | 5 March 2015 Paper

Systematic optimization of MRI guided near infrared diffuse optical spectroscopy in breast

Yan Zhao, Michael Mastanduno, Shudong Jiang, Fadi El-Ghussein, Junqing Xu, Jiang Gui, Brian Pogue, Keith Paulsen

Proceedings Volume 9316, 931605 (2015) https://doi.org/10.1117/12.2079453

KEYWORDS: Sensors, Magnetic resonance imaging, Breast, Scattering, Surface plasmons, Near infrared spectroscopy, Tumors, Tissues, Tissue optics, Near infrared

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SPIE Journal Paper | 9 July 2014 Open Access

Comparison of magnetic resonance imaging-compatible optical detectors for in-magnet tissue spectroscopy: photodiodes versus silicon photomultipliers

Fadi El-Ghussein, Shudong Jiang, Brian Pogue, Keith Paulsen

JBO, Vol. 19, Issue 07, 070502, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.070502

KEYWORDS: Sensors, Magnetic resonance imaging, Tissue optics, Photodiodes, Imaging spectroscopy, Spectroscopy, Silicon photomultipliers, Electronics, Signal detection, Palladium

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SPIE Journal Paper | 26 August 2013 Open Access

Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging

Fadi El-Ghussein, Michael Mastanduno, Shudong Jiang, Brian Pogue, Keith Paulsen

JBO, Vol. 19, Issue 01, 011010, (August 2013) https://doi.org/10.1117/12.10.1117/1.JBO.19.1.011010

KEYWORDS: Continuous wave operation, Sensors, Breast, Signal detection, Magnetic resonance imaging, Data acquisition, Imaging systems, Tissue optics, Photomultipliers, Photodiodes

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SPIE Journal Paper | 10 July 2013 Open Access

Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide

Shudong Jiang, Brian Pogue, Kelly Michaelsen, Michael Jermyn, Michael Mastanduno, Tracy Frazee, Peter Kaufman, Keith Paulsen

JBO, Vol. 18, Issue 07, 076011, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.076011

KEYWORDS: Tumors, Blood, Breast, Near infrared spectroscopy, Hyperoxia, Oxygen, Tissues, Breast cancer, Tomography, Hypoxia

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Proceedings Article | 25 March 2013 Paper

Signal-to-noise and acquisition duration improvements for a hybrid-PMT & photodiode-based multiwavelength diffuse optical tomography system

Fadi El-Ghussein, Michael Mastanduno, Shudong Jiang, Brian Pogue, Keith Paulsen

Proceedings Volume 8578, 85780X (2013) https://doi.org/10.1117/12.2002865

KEYWORDS: Data acquisition, Signal to noise ratio, Breast, Sensors, Near infrared, Signal detection, Diffuse optical tomography, Photodiodes, Chromophores, Continuous wave operation

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Proceedings Article | 25 March 2013 Paper

Absolute calibration for complex-geometry biomedical diffuse optical spectroscopy

Michael Mastanduno, Shudong Jiang, Fadi El-Ghussein, Roberta diFlorio-Alexander, Brian Pogue, Keith Paulsen

Proceedings Volume 8578, 85780W (2013) https://doi.org/10.1117/12.2002477

KEYWORDS: Calibration, Data modeling, Magnetic resonance imaging, Optical properties, Breast, Near infrared spectroscopy, Oxygen, Breast cancer, Optical fibers, Scattering

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Proceedings Article | 16 April 2012 Paper

Magnetic resonance guided optical spectroscopy imaging of human breast cancer using a combined frequency domain and continuous wave approach

Michael Mastanduno, Scott Davis, Shudong Jiang, Roberta diFlorio-Alexander, Brian Pogue, Keith Paulsen

Proceedings Volume 8317, 83171M (2012) https://doi.org/10.1117/12.912474

KEYWORDS: Magnetic resonance imaging, Near infrared spectroscopy, Breast cancer, Breast, Tumors, Scattering, Tissues, Optical imaging, Imaging systems, Mammography

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Proceedings Article | 15 June 2011 Paper

Combined three-dimensional magnetic resonance guided optical spectroscopy for functional and molecular imaging of human breast cancer

Michael Mastanduno, Scott Davis, Shudong Jiang, Roberta diFlorio-Alexander, Brian Pogue, Keith Paulsen

Proceedings Volume 8089, 80890A (2011) https://doi.org/10.1117/12.889636

KEYWORDS: Magnetic resonance imaging, Near infrared spectroscopy, Luminescence, Breast cancer, Tumors, Breast, Mammography, Scattering, Imaging systems, 3D image processing

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SPIE Journal Paper | 1 June 2011 Open Access

Remote positioning optical breast magnetic resonance coil for slice-selection during image-guided near-infrared spectroscopy of breast cancer

Michael Mastanduno, Shudong Jiang, Brian Pogue, Keith Paulsen, Roberta DiFlorio-Alexander

JBO, Vol. 16, Issue 06, 066001, (June 2011) https://doi.org/10.1117/12.10.1117/1.3587631

KEYWORDS: Breast, Magnetic resonance imaging, Interfaces, Tissue optics, Imaging systems, Magnetism, Near infrared spectroscopy, Optical fibers, Biomedical optics, Tissues

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Proceedings Article | 1 March 2011 Paper

Assessing breast tissue oxygenation using inspired gas stimulation with NIR tomography

Shudong Jiang, Tracy Frazee, Michael Jermyn, Kelly Michaelsen, Brian Pogue, Keith Paulsen, Peter Kaufman

Proceedings Volume 7896, 78962A (2011) https://doi.org/10.1117/12.874804

KEYWORDS: Breast, Near infrared, Hyperoxia, Tissues, Oxygen, Tumors, Tomography, Hypoxia, Control systems, Solids

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Proceedings Article | 1 March 2011 Paper

High frame-rate MR-guided near-infrared tomography system to monitor breast hemodynamics

Zhiqiu Li, Shudong Jiang, Venkataramanan Krishnaswamy, Scott Davis, Subhadra Srinivasan, Keith Paulsen, Brian Pogue

Proceedings Volume 7896, 78962M (2011) https://doi.org/10.1117/12.875839

KEYWORDS: Breast, Near infrared, Tissues, Imaging systems, Magnetic resonance imaging, Tomography, Sensors, Hemodynamics, Interfaces, Signal detection

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Proceedings Article | 10 February 2011 Paper

Empirical factors affecting reconstruction of image-guided near infrared spectroscopy

Michael Mastanduno, Shudong Jiang, Roberta DiFlorio-Alexander, Brian Pogue, Keith Paulsen

Proceedings Volume 7892, 789204 (2011) https://doi.org/10.1117/12.877161

KEYWORDS: Image segmentation, Calibration, Tumors, Data modeling, Magnetic resonance imaging, Tissues, Image restoration, Breast, Tissue optics, Image processing

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SPIE Journal Paper | 1 May 2010 Open Access

Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study

Colin Carpenter, Rebecca Rakow-Penner, Shudong Jiang, Bruce Daniel, Brian Pogue, Gary Glover, Keith Paulsen

JBO, Vol. 15, Issue 03, 036026, (May 2010) https://doi.org/10.1117/12.10.1117/1.3430729

KEYWORDS: Tumors, Tissues, Breast, Oxygen, Modulation, Hemodynamics, Magnetic resonance imaging, Tissue optics, Mammography, Medicine

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Proceedings Article | 12 February 2009 Paper

Wavelength optimization of the spectral derivative method improves quantification of chromophore values in NIR reconstruction

Jia Wang, Brian Pogue, Shudong Jiang, Keith Paulsen

Proceedings Volume 7174, 71740H (2009) https://doi.org/10.1117/12.810541

KEYWORDS: Chromophores, Near infrared, Diffuse optical tomography, Tomography, Absorption, Optical tomography, Tissue optics, Imaging systems, Image restoration, Scattering

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Proceedings Article | 12 February 2009 Paper

Pressure-enhanced near-infrared breast imaging: toward cancer patient imaging

Shudong Jiang, Brian Pogue, Ashley Laughney, Keith Paulsen

Proceedings Volume 7174, 71740S (2009) https://doi.org/10.1117/12.808071

KEYWORDS: Blood, Breast, Imaging systems, Data acquisition, Chromophores, Breast cancer, Tissues, Breast imaging, Near infrared spectroscopy, Cancer

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SPIE Journal Paper | 1 July 2008 Open Access

Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data

Jia Wang, Scott Davis, Subhadra Srinivasan, Shudong Jiang, Brian Pogue, Keith Paulsen

JBO, Vol. 13, Issue 04, 041305, (July 2008) https://doi.org/10.1117/12.10.1117/1.2952006

KEYWORDS: Continuous wave operation, Chromophores, Scattering, Magnetic resonance imaging, Near infrared, Spectroscopy, Tissue optics, Tomography, Breast, Tissues

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Proceedings Article | 7 March 2008 Paper

MRI-coupled spectrally resolved fluorescence tomography for in vivo imaging

Scott Davis, Summer Gibbs-Strauss, Stephen Tuttle, Shudong Jiang, Roger Springett, Hamid Dehghani, Brian Pogue, Keith Paulsen

Proceedings Volume 6850, 68500K (2008) https://doi.org/10.1117/12.764252

KEYWORDS: Luminescence, Magnetic resonance imaging, Imaging systems, Optical fibers, Optical filters, Fluorescence tomography, Spectrometers, Calibration, Image segmentation, Tissue optics

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Proceedings Article | 27 February 2008 Paper

Fluorescence quantum yield of verteporfin is independent of oxygen

Tim Monahan, Shudong Jiang, Brian Pogue

Proceedings Volume 6845, 684517 (2008) https://doi.org/10.1117/12.764244

KEYWORDS: Luminescence, Oxygen, Quantum efficiency, Blood, Yeast, Sensors, Tissue optics, Tissues, Microsensors, In vivo imaging

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Proceedings Article | 21 February 2008 Paper

Review of phantoms for tomographic imaging, with applications toward diffuse spectroscopy within clinical imaging systems

Brian Pogue, Shudong Jiang, Hamid Dehghani, Keith Paulsen

Proceedings Volume 6870, 68700K (2008) https://doi.org/10.1117/12.767691

KEYWORDS: Imaging systems, Imaging spectroscopy, Magnetic resonance imaging, Tissue optics, Spectroscopy, Near infrared, Tomography, Calibration, Tissues, Breast

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Proceedings Article | 20 February 2008 Paper

System design for spectrally encoded video-rate near infrared tomography during magnetic resonance imaging of the breast

Brian Pogue, Zhiqiu Li, Colin Carpenter, Ashley Laughney, Venkataramanan Krishnaswamy, Scott Davis, Shudong Jiang, Keith Paulsen

Proceedings Volume 6850, 68500H (2008) https://doi.org/10.1117/12.778326

KEYWORDS: Breast, Magnetic resonance imaging, Spectroscopy, Sensors, Tissues, Tomography, Breast imaging, Near infrared, Light, Imaging systems

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SPIE Journal Paper | 1 September 2007 Open Access

Receiver operating characteristic and location analysis of simulated near-infrared tomography images

Xiaomei Song, Brian Pogue, Hamid Dehghani, Shudong Jiang, Keith Paulsen, Tor Tosteson

JBO, Vol. 12, Issue 05, 054013, (September 2007) https://doi.org/10.1117/12.10.1117/1.2799197

KEYWORDS: Tomography, Near infrared, Receivers, Image processing, Biological research, Reconstruction algorithms, Absorption, Statistical analysis, Error analysis, Data modeling

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Proceedings Article | 27 March 2007 Paper

Convergence analysis and preliminary experimental feasibility for MRI-localized region spectroscopy with NIR diffuse optical tomography

Jia Wang, Scott Davis, Shudong Jiang, Brian Pogue, Keith Paulsen

Proceedings Volume 6434, 64341B (2007) https://doi.org/10.1117/12.699371

KEYWORDS: Scattering, Near infrared, Chromophores, Sapphire lasers, Spectroscopy, Laser scattering, Tissue optics, Mie scattering, Diffuse optical tomography, Tissues

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Proceedings Article | 14 February 2007 Paper

Dynamic frequency domain tomography system and phantom test

Shudong Jiang, Brian Pogue, Keith Paulsen

Proceedings Volume 6431, 64310G (2007) https://doi.org/10.1117/12.699679

KEYWORDS: Chromophores, Data acquisition, Blood, Signal detection, Tomography, Error analysis, Semiconductor lasers, Imaging systems, Breast, Tissues

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Proceedings Article | 21 July 2006 Paper

Rapid NIR optical tomography at 35 frames per second by spectrally-encoded parallel light delivery

Daqing Piao, Hamid Dehghani, Shudong Jiang, Subhadra Srinivasan, Brian Pogue

Proceedings Volume 6163, 61630K (2006) https://doi.org/10.1117/12.696968

KEYWORDS: Sensors, Imaging systems, Signal detection, Tomography, Spectroscopy, Charge-coupled devices, Data acquisition, Absorption, Tissues, Near infrared

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SPIE Journal Paper | 1 July 2006 Open Access

Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography

Xin Wang, Brian Pogue, Shudong Jiang, Hamid Dehghani, Xiaomei Song, Subhadra Srinivasan, Ben Brooksby, Keith Paulsen, Christine Kogel, Steven Poplack, Wendy Wells

JBO, Vol. 11, Issue 04, 041106, (July 2006) https://doi.org/10.1117/12.10.1117/1.2342747

KEYWORDS: Scattering, Tissues, Mie scattering, Particles, Breast, Image restoration, Tumors, Near infrared, Tissue optics, Cancer

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Proceedings Article | 13 February 2006 Paper

Instrumentation of rapid near-infrared diffuse optical tomography for imaging of tissue at 35 frames per second

Daqing Piao, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Brian Pogue

Proceedings Volume 6081, 60810N (2006) https://doi.org/10.1117/12.646619

KEYWORDS: Imaging systems, Sensors, Tomography, Spectroscopy, Signal detection, Data acquisition, Absorption, Charge-coupled devices, Light, Tissues

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SPIE Journal Paper | 1 September 2005 Open Access

Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure

Ben Brooksby, Shudong Jiang, Hamid Dehghani, Brian Pogue, Keith Paulsen, John Weaver, Christine Kogel, Steven Poplack

JBO, Vol. 10, Issue 05, 051504, (September 2005) https://doi.org/10.1117/12.10.1117/1.2098627

KEYWORDS: Magnetic resonance imaging, Near infrared, Tissues, Breast, Scattering, Absorption, Imaging systems, Tomography, Tissue optics, Reconstruction algorithms

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SPIE Journal Paper | 1 September 2005 Open Access

Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo

Xin Wang, Brian Pogue, Shudong Jiang, Xiaomei Song, Keith Paulsen, Christine Kogel, Steven Poplack, Wendy Wells

JBO, Vol. 10, Issue 05, 051704, (September 2005) https://doi.org/10.1117/12.10.1117/1.2098607

KEYWORDS: Particles, Scattering, Mie scattering, Breast, Tissues, Light scattering, Tissue optics, Refractive index, Tomography, Near infrared

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Proceedings Article | 28 April 2005 Paper

Quantifying adipose and fibroglandular breast tissue properties using MRI-guided NIR tomography

Ben Brooksby, Subhadra Srinivasan, Brian Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, John Weaver, Steven Poplack, Justin Pearlman, Keith Paulsen

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.590498

KEYWORDS: Tissues, Magnetic resonance imaging, Near infrared, Breast, Scattering, Tissue optics, Image restoration, Spatial resolution, Tomography, Imaging systems

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Proceedings Article | 28 April 2005 Paper

Spectral-encoding for parallel source implementation in NIR tomography

Daqing Piao, Shudong Jiang, Subhadra Srinivasan, Yalavarthy Kumar, Xiaomei Song, Brian Pogue

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.594061

KEYWORDS: Spectroscopy, Tomography, Signal detection, Near infrared, Charge-coupled devices, Sensors, Light, Data acquisition, Computer programming, Tissue optics

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Proceedings Article | 28 April 2005 Paper

Spectrally constrained NIR tomography for breast imaging: simulations and clinical results

Subhadra Srinivasan, Brian Pogue, Shudong Jiang, Hamid Dehghani, Keith Paulsen

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.590576

KEYWORDS: Near infrared, Tumors, Chromophores, Scattering, Oxygen, Tomography, Mie scattering, Breast, Absorption, Phase measurement

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SPIE Journal Paper | 1 November 2004 Open Access

Improved quantification of small objects in near-infrared diffuse optical tomography

Subhadra Srinivasan, Brian Pogue, Hamid Dehghani, Shudong Jiang, Xiaomei Song, Keith Paulsen

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1803545

KEYWORDS: Absorption, Reconstruction algorithms, Scattering, Breast, Optical properties, Tumors, Error analysis, Image restoration, Near infrared, Diffuse optical tomography

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SPIE Journal Paper | 1 May 2004 Open Access

Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes

Brian Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, Sandra Soho, Subhadra Srinivasan, Xiaomei Song, Tor Tosteson, Steven Poplack, Keith Paulsen

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1691028

KEYWORDS: Breast, Scattering, Tissues, Near infrared, Tissue optics, Absorption, Tumors, Oxygen, Mammography, Cancer

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SPIE Journal Paper | 1 October 2003

Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms

Shudong Jiang, Brian Pogue, Troy McBride, Marvin Doyley, Steven Poplack, Keith Paulsen

JEI, Vol. 12, Issue 04, (October 2003) https://doi.org/10.1117/12.10.1117/1.1587153

KEYWORDS: Calibration, Breast, Tissues, Sensors, Transceivers, Blood, Imaging systems, Absorption, Optical properties, Tomography

Proceedings Article | 29 July 2003 Paper

Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Subhadra Srinivasan, Brian Pogue, Shudong Jiang, Hamid Dehghani, Keith Paulsen

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478219

KEYWORDS: Absorption, Oxygen, Tissues, Blood, Error analysis, Breast, Scattering, Imaging systems, Chromophores, Near infrared

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Proceedings Article | 29 July 2003 Paper

Assessment of the menstrual cycle upon total hemoglobin, water concentration, and oxygen saturation in the female breast

Shudong Jiang, Brian Pogue, Subhadra Srinivasan, Sandra Soho, Steven Poplack, Tor Tosteson, Keith Paulsen

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478148

KEYWORDS: Breast, Tissues, Oxygen, Blood, Imaging systems, Mammography, Near infrared, Interfaces, Tomography, Chest

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Proceedings Article | 29 July 2003 Paper

Optical images from pathophysiological signals within breast tissue using three-dimensional near-infrared light

Hamid Dehghani, Brian Pogue, Shudong Jiang, Steven Poplack, Keith Paulsen

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.476807

KEYWORDS: Tissue optics, Absorption, Breast, Near infrared, 3D image processing, Oxygen, Blood, Geometrical optics, Tissues, Image restoration

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SPIE Journal Paper | 1 April 2003 Open Access

Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom

Shudong Jiang, Brian Pogue, Troy McBride, Keith Paulsen

JBO, Vol. 8, Issue 02, (April 2003) https://doi.org/10.1117/12.10.1117/1.1559692

KEYWORDS: Calibration, Absorption, Breast, Blood, Imaging systems, Sensors, Scattering, Tissue optics, Tissues, Optical properties

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SPIE Journal Paper | 1 January 2002 Open Access

Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast

Troy McBride, Brian Pogue, Steven Poplack, Sandra Soho, Wendy Wells, Shudong Jiang, Ulf Oesterberg, Keith Paulsen

JBO, Vol. 7, Issue 01, (January 2002) https://doi.org/10.1117/12.10.1117/1.1428290

KEYWORDS: Breast, Near infrared, Scattering, Tomography, Absorption, Mammography, Tissues, Fiber optics, Chromophores, Laser scattering

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Proceedings Article | 29 June 2001 Paper

Analysis of circular source-detector geometries for near-infrared tomographic imaging

Brian Pogue, Troy McBride, Shudong Jiang, Ulf Oesterberg, Keith Paulsen

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434522

KEYWORDS: Sensors, Absorption, Scattering, Tissue optics, Signal detection, Image quality, Computer simulations, Breast, Image restoration, Diffusion

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Proceedings Article | 29 June 2001 Paper

Preliminary study of near-infrared tomographic imaging of heterogeneous media: simulations and images of excised breast tissue

Troy McBride, Brian Pogue, Wendy Wells, Shudong Jiang, Ulf Oesterberg, Keith Paulsen

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434491

KEYWORDS: Breast, Tissues, Scattering, Absorption, Optical properties, Reconstruction algorithms, Computer simulations, Tissue optics, Tomography, Data acquisition

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