Dr. Tamar Kadar Profile

Dr. Tamar Kadar

at Israel Institute for Biological Research

SPIE Involvement:

Author

Proceedings Article | 5 March 2007 Paper

Histological aspects of retinal damage following exposure to pulsed Nd:YAG laser radiation in rabbits: indication for mechanism

T. Kadar, D. Peri, J. Turetz, E. Fishbine, R. Sahar, I. Egoz, N. Sapiens, R. Brandeis

Proceedings Volume 6426, 642622 (2007) https://doi.org/10.1117/12.700284

KEYWORDS: Retina, Injuries, Q switched lasers, Nd:YAG lasers, Photography, Tissue optics, Q switching, Microscopy, Radiation injury, Laser tissue interaction

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Proceedings Article | 7 March 2006 Paper

Optical system for exposure of rabbit eyes to laser light and in situ assessment of retinal damage

D. Peri, J. Turetz, E. Fishbine, I. Egoz, T. Kadar, R. Brandeis

Proceedings Volume 6138, 61381Q (2006) https://doi.org/10.1117/12.645583

KEYWORDS: Eye, Retina, Nd:YAG lasers, Mirrors, Inspection, CCD cameras, Light sources, Optical design, Q switched lasers, Laser damage threshold

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Proceedings Article | 18 April 2005 Paper

Retinal damage following exposure to pulsed Nd:YAG laser radiation in rabbits and its relation to physical parameters

Rachel Brandeis, David Peri, Josef Turetz, Eliezer Fishbine, Inbal Egoz, Tamar Kadar

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.588567

KEYWORDS: Retina, Nd:YAG lasers, Q switched lasers, Injuries, Eye, Biological research, Statistical analysis, Telescopes, Analytical research, Q switching

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Proceedings Article | 1 July 2004 Paper

Retinal damage following exposure to single pulses of Nd:YAG laser radiation in rabbits and its relation to energy levels

T. Kadar, David Peri, J. Turetz, Noam Sapiens, E. Fishbine, R. Sahar, I. Egoz, R. Brandeis

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.558526

KEYWORDS: Retina, Nd:YAG lasers, Q switched lasers, Analytical research, Laser damage threshold, Laser tissue interaction, Laser safety, Biological research, Laser energy, Eye

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Purpose: The aim of the present study was to characterize permissible exposure limits (MPE) for safety analysis, with an emphasis on the immediate retinal damage following SHG of Nd:YAG Q-Switched laser radiation and to test its correlation to physical parameters. Methods: Pigmented rabbits (n=14) were exposed to single pulses of Nd:YAG laser radiation (532nm, pulse duration:8-12ns) in various energies ranging from 10 to 150 μJ. Exposures were conducted in retina tissue, very close to the optic nerve, with a total of 20 exposures per retina. Retinas were viewed during the first 15 min following exposure, using an on-line digital video camera. Thereafter, animals were sacrificed for histological evaluation. A quantitative analysis of the clinical findings, based on a severity score scale and a morphometric analysis of the extent of the lesions, was used to test the relationship with the laser energy. In addition, hemorrhage thresholds were computed using Probit Analysis. Results: Retinal damage, at various levels of severity, was observed immediately after exposure to energies above 26 μJ, characterized by edema and sub-retinal hemorrhages. The appearance and severity of the lesions varied among animals, between fellow eyes and even within the same retina. The ED50 for immediate pre-retinal hemorrhage was determined as 83μJ and the lesions’ diameter ranged from 141-640μ. A significant correlation (R=0.80, P<0.0001) was found between the extent of the lesions and energy levels. The diameter of the lesions showed a linear (P<0.008) increase with the laser energy. The histological observations indicated elevation of retinal layers and extensive damage in the outer segment of the photoreceptors and in the pigmented epithelial cells layer. Conclusions: A linear, laser-retinal tissue interaction was found immediately following exposure to single pulses of Nd:YAG laser radiation. It is suggested that unlike argon laser, which produces a thermal burn to the eye, Nd:YAG laser damage is a result of a combination of photo-mechanical and thermal mechanism.

Conference Committee Involvement (2)

Laser and Noncoherent Light Ocular Effects

20 January 2008 | San Jose, California, United States

Laser and Noncoherent Light Ocular Effects

21 January 2007 | San Jose, California, United States

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